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Research Publications / Cartilage Chondrocytes

Functional tissue-engineered microtissue derived from cartilage extracellular matrix for articular cartilage regeneration. Yin H, Wang Y, Sun X, Cui G, Sun Z, Chen P, Xu Y, Yuan X, Meng H, Xu W, Wang A, Guo Q, Lu S, Peng J. Acta Biomater. 2018  S1742-7061(18)30425-2. [Abstract]

Effects of collagen matrix and bioreactor cultivation on cartilage regeneration of a full-thickness critical-size knee joint cartilage defects with subchondral bone damage in a rabbit model. Wang KH, Wan R, Chiu LH, Tsai YH, Fang CL, Bowley JF, Chen KC, Shih HN, Lai WT. PLoS One;13(5):e0196779 [Abstract]

Coculture of meniscus cells and mesenchymal stem cells in simulated microgravity.
Weiss WM, Mulet-Sierra A, Kunze M, Jomha NM, Adesida AB.NPJ Microgravity. 2017 Nov 10;3:28. doi: 10.1038/s41526-017-0032-x. eCollection 2017. [Full Text]

Generating mechanically stable, pediatric, and scaffold-free nasal cartilage constructs in vitro
Akbari P, Waldman SD, Propst E, Cushing SL, Weber JF, Yeger H, Farhat WA. Tissue Eng Part C Methods. 2016 Nov 9. [Abstract]

Transfection of the IHH gene into rabbit BMSCs in a simulated microgravity environment promotes chondrogenic differentiation and inhibits cartilage aging. 
Liu PC, Liu K1, Liu JF, Xia K, Chen LY, Wu X. Oncotarget. 2016 Sep 6;7(39):62873-62885. doi: 10.18632/oncotarget.11871. [Abstract] [FullText]

Numerical Simulation of Mass Transfer and Three-Dimensional Fabrication of Tissue-Engineered Cartilages Based on Chitosan/Gelatin Hybrid Hydrogel Scaffold in a Rotating Bioreactor.
Zhu Y, Song K, Jiang S, Chen J, Tang L, Li S, Fan J, Wang Y, Zhao J, Liu T.Appl Biochem Biotechnol. 2016 Aug 15. [Abstract]

Pediatric laryngotracheal reconstruction with tissue-engineered cartilage in a rabbit model.
Jacobs IN, Redden RA, Goldberg R, Hast M, Salowe R, Mauck RL, Doolin EJ.Laryngoscope. 2016 Jan;126 Suppl 1:S5-21. doi: 10.1002/lary.25676. [Abstract]

Induction of mesenchymal stem cell chondrogenic differentiation and functional cartilage microtissue formation for in vivo cartilage regeneration by cartilage extracellular matrix-derived particles.
Yin H, Wang Y, Sun Z, Sun X, Xu Y, Li P, Meng H, Yu X, Xiao B, Fan T, Wang Y, Xu W, Wang A, Guo Q, Peng J, Lu S.Acta Biomater. 2016 Jan 20. pii: S1742-7061(16)30024-1. doi: 10.1016/j.actbio.2016.01.024. [Abstract]

Chondrogenic differentiation of human adipose derived stem cells using microcarrier and bioreactor combination technique.
Kang H, Lu S, Peng J, Yang Q, Liu S, Zhang L, Huang J, Sui X, Zhao B, Wang A, Xu W, Guo Q, Song Q. Mol Med Rep. 2014 Oct 30. doi: 10.3892/mmr.2014.2820. [Abstract]
Optimal 3D culture of primary articular chondrocytes for use in the rotating wall vessel bioreactor.
Mellor LF, Baker TL, Brown RJ, Catlin LW, Oxford JT. Aviat Space Environ Med. 2014 Aug;85(8):798-804. doi: 10.3357/ASEM.3905.2014. [Abstract] [Full Text] [Full Text pdf]
Characteristics of mesenchymal stem cells derived from Wharton's jelly of human umbilical cord and for fabrication of non-scaffold tissue-engineered cartilage.
Liu S, Hou KD, Yuan M, Peng J, Zhang L, Sui X, Zhao B, Xu W, Wang A, Lu S, Guo Q.; J Biosci Bioeng. 2013 Jul 27. pii: S1389-1723(13)00263-6. doi: 10.1016/j.jbiosc.2013.07.001. [Abstract]
The effect of the microgravity rotating culture system on the chondrogenic differentiation of bone marrow mesenchymal stem cells.
Wu X, Li SH, Lou LM, Chen ZR. Mol Biotechnol. 2013 Jun;54(2):331-6. doi: 10.1007/s12033-012-9568-x. [Abstract]

Flexural properties of native and tissue-engineered human septal cartilage.
Caffrey JP, Kushnaryov AM, Reuther MS, Wong VW, Briggs KK, Masuda K, Sah RL, Watson D. Otolaryngol Head Neck Surg. 2013 Apr;148(4):576-81. doi: 10.1177/0194599812474228. Epub 2013 Jan 15. [Abstract]
Culture of Human Septal Chondrocytes in a Rotary Bioreactor.
Reuther MS, Wong VW, Briggs KK, Chang AA, Nguyen QT, Schumacher BL, Masuda K, Sah RL, Watson D. Otolaryngol Head Neck Surg. 2012 Oct;147(4):661-7. [Abstract]
Human elastic cartilage engineering from cartilage progenitor cells using rotating wall vessel bioreactor. 
Takebe T, Kobayashi S, Kan H, Suzuki H, Yabuki Y, Mizuno M, Adegawa T, Yoshioka T, Tanaka J,Maegawa J, Taniguchi H. Transplant Proc. 2012 May;44(4):1158-61. [Abstract]
One-step articular cartilage repair: combination of in situ bone marrow stem cells with cell-free poly(L-lactic-co-glycolic acid) scaffold in a rabbit model.
Shi J, Zhang X, Zeng X, Zhu J, Pi Y, Zhou C, Ao Y. Orthopedics. 2012 May;35(5):e665-71. doi: 10.3928/01477447-20120426-20. [Abstract]
Simulated microgravity using a rotary cell culture system promotes chondrogenesis of human adipose-derived mesenchymal stem cells via the p38 MAPK pathway. 
Yu B, Yu D, Cao L, Zhao X, Long T, Liu G, Tang T, Zhu Z. Biochem Biophys Res Commun.;414(2):412-8 Oct 2011 [Abstract]
Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions.
Sheehy EJ, Buckley CT, Kelly DJ., J Tissue Eng Regen Med. 2011 Oct;5(9):747-58. doi: 10.1002/term.385. Epub Jan 2011 [Abstract]
A validated model of GAG deposition, cell distribution and growth of tissue engineered cartilage cultured in a rotating bioreactor.
Nikolaev NI, Obradovic B, Versteeg HK, Lemon G, Williams DJ. Biotechnol Bioeng 105:842-853, 2010 [Abstract]
Computational fluid dynamics modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering.
Cinbiz MN, Tığli RS, Beşkardeş IG, Gümüşderelioğlu M, Colak U. J Biotechnol; 150(3):389-95; 2010 [Abstract]
Cross-linking density alters early metabolic activities in chondrocytes encapsulated in poly(ethylene glycol) hydrogels and cultured in the rotating wall vessel.
Villanueva I, Klement BJ, Von Deutsch D, Bryant SJ. Biotechnol Bioeng. 102:1242-50, 2009. [Abstract]
Rotating three-dimensional dynamic culture of adult human bone marrow-derived cells for tissue engineering of hyaline cartilage.
Sakai S, Mishima H, Ishii T, Akaogi H, Yoshioka T, Ohyabu Y, Chang F, Ochiai N, Uemura T.; Journal Orthop Res.27:517-21, 2009. [Abstract]
Cell-Nanofiber-Based Cartilage Tissue Engineering Using Improved Cell Seeding, Growth Factor, and Bioreactor Technologies.
Li WJ, Jiang YJ, Tuan RS. Tissue Eng Part A 14: 639-648, 2008 [Abstract]
Engineering of Functional Cartilage Tissue Using Stem Cells from Synovial Lining: A Preliminary Study.
Pei M, He F, Kish VL, Vunjak-Novakovic G. Clin Orthop Relat Res 466: 1880-1889, 2008 [Abstract] [Full Text] [Full Text pdf]
Engineering of rat articular cartilage on porous sponges: effects of tgf Beta 1 and microgravity bioreactor culture.
Emin N, Koc A, Durkut S, Elcin AE, Elcin YM. Artif Cells Blood Substit Immobil Biotechnol 36: 123137, 2008 [Abstract]
Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds and bioreactors.
August A, Marolt D, Freed LE, Vepari C, Meinel L, Farley M, Fajardo R, Patel M, Gray M, Kaplan DL, Vunjak-Novakovic G J R Soc Interface. 2008 Aug 6;5(25):929-39. doi: 10.1098/rsif.2007.1302 [Abstract[Full Text]
An ex vivo model for chondrogenesis and osteogenesis.
Pound JC, Green DW, Roach HI, Mann S, Oreffo RO. Biomaterials 28:2839-2849, 2007 [Abstract]
Strategies to Promote Chondrogenesis and Osteogenesis from Human Bone Marrow Cells and Articular Chrondrocytes Encapsulated in Polysaccharide Templates.
Pound JC, Green DW, Chaudhuri JB, Mann S, Roach HI, Oreffo RO. Tissue Eng 12:2789-2799, 2006 [Abstract]
Cartilaginous tissue formation from bone marrow using rotating wall vessel (RWV) bioreactor.
Ohyabu Y, Kida N, Kojima H, Taguchi T, Tanaka J, Uemura T.; Biotechnol. Bioeng. 95: 1003-1008, 2006 [Abstract]
Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors.
Marolt D, Augst A, Freed LE, Vepari C, Fajardo R, Patel N, Gray M, Farley M, Kaplan D, Vunjak-Novakovic G. Biomaterials 27: 6138-6149, 2006 [Abstract]
Development and remodeling of engineered cartilage-explant composites in vitro and in vivo.
Tognana, E., Padera, R.F., Chen, F., Vunjak-Novakovic, G., Freed, L.E.; Osteoarthritis and Cartilage 13: 896-905, 2005 [Abstract]
Adjacent Tissue (Cartilage, Bone) Affect the Functional Integration of Engineered Calf Cartilage in vitro.
Tognana, E., Chen, F., Padera, R.F., Leddy, H.A, Christensen, S.E., Guilak, F., Vunjak-Novakovic, G., Freed, L.E.; Osteoarthritis and Cartilage 13: 129-138, 2005 [Abstract]
Low-density Cultures of Bovine Chondrocytes: Effects of Scaffold Material and Culture System.
Hu JC, Athanasiou KA;  Biomaterials 26:2001-2012, 2005. [Abstract]
Chondrogenesis of Aged Human Articular Cartilage in a Scaffold-Free Bioreactor
Marlovits S, Tichy B, Truppe M, Gruber D, Vecsei V. Tissue Eng. 9: 1215-1226, 2003. [Abstract]
Collagen Expression in Tissue Engineered Cartilage of Aged Human Articular Chondrocytes in a Rotating Bioreactor
Marlovits S, Tichy B, Truppe M, Gruber D, Schlegel W.; Int. Jour. Artificial Organs 26: 319-330, 2003. [Abstract]
Articular Cartilage Bioreactors and Bioprocesses
Darling EM, Athanasiou KA; Tissue Eng. 9: 9-26, 2003. [Abstract]
Bioreactors Mediate the Effectiveness of Tissue Engineering Scaffolds
Pei M, Solchaga LA, Seidel J, Zenf L. Vunjak-Novakovic G, Caplan AI, Freed LE; FASEB J 16:1691-4, 2002. [Abstract] [Full Text pdf]
Growth factors for sequential cellular de-and re-differentiation in tissue engineering
Pei M, .Seidel J, G.Vunjak-Novakovic,and.Freed L.E. Biochem Biophysl Res Commun 294, 149-154, 2002 [Abstract]
Bioreactor Studies of Native and Tissue Engineered Cartilage
Vunjak-Novakovic G, Obradovic B, Martin I, Freed LE: Biorheology 39:259-268, 2002. [Abstract]
Tissue Engineering with Chondrocytes
Koch RJ, Gorti GK: Facial Plast Surg 18:59-68, 2002. [Abstract]
IGF-I and Mechanical Environment Interact to Modulate Engineered Cartilage Development
Gooch KJ, Blunk T, Courter DL, Sieminski AL, Bursac PM, Vunjak-Novakovic G and Freed L.E.; Biochem Biophys Res Commun 286: 909-15, 2001. [Abstract]
Modulation of the Mechanical Properties of Tissue Engineered Cartilage
Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, Freed LE, and Vunjak-Novakovic G; Biorheology 37:141-7, 2000. [Abstract]
Growth of Tissue-Engineered Human Nasoseptal Cartilage in Simulated Microgravity
Falsafi S and Koch RJ; Arch Otolaryngol Head Neck Surg 126:759-765, 2000. [Abstract][Full Text] [Full Text pdf]
Bioreactor Cultivation Conditions Modulate the Composition and Mechanical Properties of Tissue-Engineered Cartilage
Vunjak-Novakovic G, Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, and Freed L; J Orthop Res 17: 130-138, 1999. [Abstract]
Gas Exchange is Essential for Bioreactor Cultivation of Tissue Engineered Cartilage
Obradovic B, Carrier R, Vunjak-Novakovic G and Freed LE;  Biotechnol Bioeng 63: 197-205, 1999. [Abstract]
Frontiers in Tissue Engineering –In Vitro Modulation of Chondrogenesis.
Freed L, Martin I and Vunjak-Novakovic G; Clinical Orthopedics and Related Research 367S:S46-S58, 1999. [Abstract]
Chondrogenesis in a Cell-Polymer Bioreactor system
Freed L. et al: Exp Cell Res 240: 58-65, 1998. [Abstract]
Collagen in Tissue-Engineered Cartilage: Types Structure, and Crosslinks
Riesle J, Hollander AP, Langer R, Freed LE, and Vunjak-Novakovic G; J Cell Biochem 71: 313-27, 1998. [Abstract]
Three Dimensional Culture of Bovine Chondrocytes in Rotating-Wall Vessels.
Baker TL and Goodwin TJ; In vitro Cell Dev Biol Anim 33: 358-365, 1997. [Abstract]
Chondrogenesis in Aggregates of Embryonic Limb Cells Grown in a Rotating Wall Vessel
Duke PJ, Daane E, Arizpe J and Montufar-Solis D; Adv. Space Research 17: 289-293, 1996. [Abstract]
Studies of Chondrogenesis in Rotating Systems
Duke PJ, Daane EL, Montufar-Solis D: J Cell Biochem 51: 274282,1993. [Abstract]
Cultivation of Cell-Polymer Cartilage Implants in Bioreactors
Freed LE, Vunjak-Novakovic G and Langer R; J Cell Biochem 51: 257-64, 1993. [Abstract]
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