Synthecon: 3D Culture Systems for 3D World!

Research Publications / Fluid Mechanical Principles of the RCCS

Numerical simulation of fluid field and in vitro three-dimensional fabrication of tissue-engineered bones in a rotating bioreactor and in vivo implantation for repairing segmental bone defects.
Song K, Wang H, Zhang B, Lim M, Liu Y, Liu T. Cell Stress Chaperones. 2013 Mar;18(2):193-201. doi: 10.1007/s12192-012-0370-2.[Abstract] [Full Text] [Full Text pdf]
Computational modeling for the optimization of a cardiogenic 3D bioprocess of encapsulated embryonic stem cells.
Consolo F, Bariani C, Mantalaris A, Montevecchi F, Redaelli A, Morbiducci U. Biomech Model Mechanobiol., Apr 2011 [abstract]
Computational fluid dynamics modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering.
Cinbiz MN, Tığli RS, Beşkardeş IG, Gümüşderelioğlu M, Colak U. J Biotechnol; 150(3):389-95; 2010 [abstract]
Tracking large solid constructs suspended in a rotating bioreactor: A combined experimental and theoretical study
Cummings LJ, Sawyer NB, Morgan SP, Rose FR, Waters SL.Biotechnol Bioeng 104:1224-1234, 2009 [Abstract]
Potential Effect of Geometry on Wall Shear Stress Distribution Across Scaffold Surfaces.
Gutierrez RA, Crumpler ET.  Ann Biomed Eng. 36: 77-85, 2008 [Abstract]
Tissue growth in a rotating bioreactor. Part II: fluid flow and nutrient transport problems.
Cummings LJ, Waters SL.  Math Med Biol 24: 169-208, 2007 [Abstract]
Model of the mass transport to the surface of animal cells cultured in a rotating bioreactor operated in micro gravity.
Rivera-Solorio I, Kleis SJ:  Biotechnol Bioeng. 94: 495-504, 2006. [Abstract]
Numerical simulation of microcarrier motion in a rotating wall vessel bioreactor.
Ju Z, Liu T, Ma X, Cui Z.  Biomed Environ Sci 19: 163-168, 2006 [Abstract]
Fluids, Materials, and Microgravity: Numerical Techniques and Insights into the Physics
Lappa, M. . Naples, Italy: Elsevier Science Oxford, 2004. (Textbook)
Quantitative Analysis of Three- Dimensional Fluid Flow in Rotating Bioreactors for Tissue Engineering
Botchwey EA, Pollack SR, Levine EM, Johnston ED, Leurencin CT:. J Biomed Mater Res 69: 205-215, 2004. [Abstract]
Organic Tissues in Rotating Bioreactors: Fluid-Mechanical Aspects, Dynamic Growth Models, and Morphological Evolutions.
Lappa M:  Biotechnol Bioeng. 84: 518-532, 2003. [Abstract]
Optimized Suspension Culture: The Rotating-Wall Vessel
Hammond TG, and Hammond JM: . Am J Physiol Renal Physiol 281: F12-F25, 2001. [Abstract] [Full Text] [Full Text pdf]
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