Synthecon: 3D Culture Systems for 3D World!

Research Publications / General Review Articles

Effect of Rotation on Scaffold Motion and Cell Growth in Rotating Bioreactors.
Varley MC, Markaki AE, Brooks RA. Tissue Eng Part A. 2017 Jan 26. doi: 10.1089/ten.TEA.2016.0357. [Abstract]

Three-Dimensional Rotating Wall Vessel-Derived Cell Culture Models for Studying Virus-Host Interactions.
Gardner JK, Herbst-Kralovetz MM.Viruses. 2016 Nov 9;8(11). pii: E304. [Abstract] [FullText]

Scaffold-free Tissue Formation Under Real and Simulated Microgravity Conditions.
Aleshcheva G, Bauer J, Hemmersbach R, Slumstrup L, Wehland M, Infanger M, Grimm D.Basic Clin Pharmacol Toxicol. 2016 Oct;119 Suppl 3:26-33. doi: 10.1111/bcpt.12561. [Abstract]

The International Space Station: an Extreme Environment for Key Host-Microbe Discoveries
C. Mark Ott, Thomas Marshburn, and Cheryl A. Nickerson. Microbe—Volume 11, Number 6, 2016, Pages 253-261. [Abstract]

From Single Cells to Engineered and Explanted Tissues: New Perspectives in Bacterial Infection Biology.
Bergmann S, Steinert M.Int Rev Cell Mol Biol. 2015;319:1-44. doi: 10.1016/bs.ircmb.2015.06.003. Epub 2015 Jul 21. [Abstract]

Growing tissues in real and simulated microgravity - new methods for tissue engineering.
Grimm D, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, Ulbrich C, Magnusson NE, Infanger M, Bauer J.; Tissue Eng Part B Rev. 2014 Apr 4. [Epub ahead of print] [Abstract]
Culturing and applications of rotating wall vessel bioreactor derived 3D epithelial cell models. *Video Article
Radtke AL, Herbst-Kralovetz MM. J Vis Exp. 2012 Apr 3;(62). pii: 3868. doi: 10.3791/3868. [abstract]
3D sample preparation for orthopaedic tissue engineering bioreactors. 
Cartmell SH, Rathbone S, Jones G, Hidalgo-Bastida LA. (Textbook chapter in 3D Cell Culture: Methods and Protocols, ISBN 978-1-60761-983-3) [abstract]
Bioreactor systems for bone tissue engineering.
Rauh J, Milan F, Günther KP, Stiehler M. Tissue Eng Part B Rev. 2011 Aug;17(4):263-80. [Abstract]
Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions.
Barrila J, Radtke AL, Crabbé A, Sarker SF, Herbst-Kralovetz MM, Ott CM, Nickerson CA. Nat Rev Microbiol. 2010 Nov;8(11):791-801 [Abstract]
Spaceflight and modeled microgravity effects on microbial growth and virulence.
Rosenzweig JA, Abogunde O, Thomas K, Lawal A, Nguyen YU, Sodipe A, Jejelowo O. Appl Microbiol Biotechnol 85:885-891, 2010 [Abstract] [Full Text] [Full Text pdf]
The application of low shear modeled microgravity to 3-D cell biology and tissue engineering.
Navran S. Biotechnol Ann Rev. 14: 275-296, 2008 [Abstract]
Studying host-pathogen interactions in 3-D: organotypic models for infectious disease and drug development.
Nickerson CA, Richter EG, Ott CM; J Neuroimmune Pharmacol. 2:26-31, 2007 [Abstract]
Low-Shear Modeled Microgravity: A Global Environmental Regulatory Signal Affecting Bacterial Gene Expression, Physiology, and Pathogenesis. Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, LeBlanc CL,et al. Journal of Microbiol Methods 54:1-11, 2003 [Abstract]
Optimized Suspension Culture: The Rotating-Wall Vessel
Hammond TG, and Hammond JM: . Am J Physiol Renal Physiol 281: F12-F25, 2001. [Abstract] [Full Text] [Full Text pdf]

Growing Tissues in Microgravity.
Unsworth BR and Lelkes PI:  Nature Medicine 4: 901-907, 1998.
Tissue Culture in Microgravity.
 Duray PH, Hatfill SJ and Pellis NR: Science & Medicine, 4: 45-55, 1997. [Abstract]
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