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Research Publications / Hematopoietic System

T cell resistance to activation by dendritic cells requires long-term culture in simulated microgravity.
Bradley JH, Stein R, Randolph B, Molina E, Arnold JP, Gregg RK. Life Sci Space Res (Amst). 2017 Nov;15:55-61. doi: 10.1016/j.lssr.2017.08.002. Epub 2017 Aug 8. [Abstract]

A Study of Alterations in DNA Epigenetic Modifications (5mC and 5hmC) and Gene Expression Influenced by Simulated Microgravity in Human Lymphoblastoid Cells.
Chowdhury B, Seetharam A, Wang Z, Liu Y, Lossie AC, Thimmapuram J, Irudayaraj J. PLoS One. 2016 Jan 28;11(1):e0147514. doi: 10.1371/journal.pone.0147514. eCollection 2016. [Abstract] [Full Text]

Integrated Biophysical and Biochemical Signals Augment Megakaryopoiesis and Thrombopoiesis in a Three-Dimensional Rotary Culture System.
Yang Y, Liu C, Lei X, Wang H, Su P, Ru Y, Ruan X, Duan E, Feng S, Han M, Xu Y, Shi L, Jiang E, Zhou J. Stem Cells Transl Med. 2015 Dec 23. pii: sctm.2015-0080 [Abstract] 

Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early t-cell activation. 
Martinez EM, Yoshida MC, Candelario TT, Hughes-Fulford M. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 7:ajpregu.00449.2014. doi:10.1152/ajpregu.00449.2014. [Epub ahead of print] [Abstract]
 
Experimental study on effect of simulated microgravity on structural chromosome instability of human peripheral blood lymphocytes.
Wei L, Liu C, Kang L, Liu Y, Shi S, Wu Q, Li Y.  PLoS One. 2014 Jun 25;9(6):e100595. doi: 10.1371/journal.pone.0100595. eCollection 2014. [Abstract] [Full Text] [Full Text pdf]
 
Integration Analysis of MicroRNA and mRNA Expression Profiles in Human Peripheral Blood Lymphocytes Cultured in Modeled Microgravity.
Girardi C, De Pittà C, Casara S, Calura E, Romualdi C, Celotti L, Mognato M. Biomed Res Int. 2014;2014:296747. doi: 10.1155/2014/296747 [Abstract] [Full Text] [Full Text pdf]
 
Early exposure of murine embryonic stem cells to hematopoietic cytokines differentially directs definitive erythropoiesis and cardiomyogenesis in alginate hydrogel three-dimensional cultures.
Fauzi I, Panoskaltsis N, Mantalaris A. Stem Cells Dev. 2014 Jun 13. (Epub ahead of print) [Abstract]
 
Microgravity control of autophagy modulates osteoclastogenesis.
Sambandam Y, Townsend MT, Pierce JJ, Lipman CM1, Haque A, Bateman TA, Reddy SV; Bone. 2014 Jan 23. pii: S8756-3282(14)00006-4. doi: 10.1016/j.bone.2014.01.004. [Abstract]
 
Microgravity inhibition of lipopolysaccharide-induced tumor necrosis factor-α expression in macrophage cells.
Wang C, Luo H, Zhu L, Yang F, Chu Z, Tian H, Feng M, Zhao Y, Shang P.; Inflamm Res. 2014 Jan;63(1):91-8. doi: 10.1007/s00011-013-0676-2 [Abstract]
 
Simulated microgravity increases heavy ion radiation-induced apoptosis in human B lymphoblasts.
Dang B, Yang Y, Zhang E, Li W, Mi X, Meng Y, Yan S, Wang Z, Wei W, Shao C, Xing R, Lin C; Life Sci. 2013 Dec 21. pii: S0024-3205(13)00755-8. doi:10.1016/j.lfs.2013.12.008  [Abstract]
 
Novel alginate three-dimensional static and rotating culture systems for effective ex vivo amplification of human cord blood hematopoietic stem cells and in vivo functional analysis of amplified cells in NOD/SCID mice. 
Yuan Y, Sin WY, Xue B, Ke Y, Tse KT, Chen Z, Xie Y, Xie Y. Transfusion. 2013 Feb 5. doi: 10.1111/trf.12103. [Abstract]
 
Cordyceps Sinensis Enhances Lymphocyte Proliferation and CD Markers Expression in Simulated Microgravity Environment.Hao T, Li JJ, DU ZY, Duan CM, Wang YM, Wang CY, Song JP, Wang LJ, Li YH, Wang Y.Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Oct;20(5):1212-5. (Article is in Chinese) [Abstract]
 
Properties of mechano-transduction via simulated microgravity and its effects on intracellular trafficking of VEGFR's.
Puca A, Russo G, Giordano A. Oncotarget. 2012 Apr; 3(4):426-34. [Abstract]
 
Effect of lentinan against immunosuppression of lymphocytes cultured in simulated microgravity environment.
Hao T, Wang YM, Li JJ, Du ZY, Duan CM, Wang CY, Song JP, Wang LJ, Li YH, Wang Y. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Feb;20(1):182-6.(Article in Chinese) [Abstract in English]
 
Analysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiationresponse of human lymphocytes under modeled microgravity.
Girardi C, De Pittà C, Casara S, Sales G, Lanfranchi G, Celotti L, Mognato M. PLoS One. 2012; 7(2):e31293. [Abstract] [Full Text] [Full Text pdf]
 
Synergistic Effects of Incubation in Rotating Bioreactors and Cumulative Low Dose60 Co γ-ray Irradiation on Human Immortal Lymphoblastoid Cells.
Wei L, Han F, Yue L, Zheng H, Yu D, Ma X, Cheng H, Li Y. Microgravity Science and Technology. 2012 Nov; 24(5): 335-344. doi: 10.1007/s12217-012-9324-7. [Abstract]
Alveolar epithelium protects macrophages from quorum sensing-induced cytotoxicity in a three-dimensional co-culture model.
Crabbé A, Sarker SF, Van Houdt R, Ott CM, Leys N, Cornelis P, Nickerson CA. Cell Microbiol. 2011 Mar;13(3):469-81. doi: 10.1111/j.1462-5822.2010.01548.x. [Abstract]
 
Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions.
Sheehy EJ, Buckley CT, Kelly DJ., J Tissue Eng Regen Med. 2011 Oct;5(9):747-58. doi: 10.1002/term.385. Epub Jan 2011 [Abstract]
 
Simultaneous expansion and harvest of hematopoietic stem cells and mesenchymal stem cells derived from umbilical cord blood.
Kedong S, Xiubo F, Tianqing L, Macedo HM, LiLi J, Meiyun F, Fangxin S, Xuehu M, Zhanfeng C 21(12):3183-93, 2010 [Abstract]
 
The effect of simulated microgravity on human mesenchymal stem cells cultured in an osteogenic differentiation system: a bioinformatics study.
Sheyn D, Pelled G, Netanely D, Domany E, Gazit D. Tissue Eng Part A. 16(11):3403-12, 2010 [Abstract]
 
Simulated microgravity-induced epigenetic changes in human lymphocytes.
J Cell Biochem 111:123-129, 2010 [Abstract]
 
Cellular and genetic adaptation in low-gravity environments.
Sundaresan A, Pellis NR. Ann N Y Acad Sci. 1161:135-46, 2009 [Abstract]
 
The influence of leptin on the activity of lung lymphocytes under simulated microgravity.
Li X, Liu CT, Zhou H. Eur J App Physiol. 107: 335-44, 2009 [Abstract]
 
Sub-mitogenic phorbol myristate acetate co-stimulation rescues the PHA-induced activation of both naïve and memory T cells cultured in the rotating-wall vessel bioreactor.
Simmons DM, Gardner EM, Lelkes PI. Cell Biol Intl. 33:882-6, 2009 [Abstract]
 
Simulated microgravity decreases DNA repair capacity and induces DNA damage in human lymphocytes.
Kumari R, Singh KP, Dumond JW Jr. J. Cell Biochem.107:723-31, 2009 [Abstract]
 
Gene expression alterations in activated human T-cells induced by modeled microgravity.
Ward NE, Pellis NR, Risin SA, Risin D.; J. Cell. Biochem. 99: 1187-1202, 2006 [Abstract]
 
Dynamic culture in a rotating-wall vessel bioreactor differentially inhibits murine T-lymphocyte activation by mitogenic stimuli upon return to static conditions in a time- dependent manner.
Simons DM, Gardner EM, Lelkes PI:  J Appl Physiol 100: 1287-1292, 2006. [Abstract] [Full Text] [Full Text pdf]
 
Functional recovery of peripheral blood mononuclear cells in modeled microgravity.
Ritz BW, Lelkes PI, Gardner EM; FASEB J. 20: 305-307, 2006. [Abstract] [Full Text pdf]
 
Impact of Modeled Microgravity on Migration, Differentiation, and Cell Cycle Control of Primitive Human Hematopoietic Progenitor Cells.
Plett PA, Abonour R, Frankovitz SM, Orschell CM; Experimental Hematology 32: 773-781, 2004. [Abstract]
 
Effect of Simulated Microgravity on the Production of IL-12 by PBMC’s.
Bakos A, Varkonyi A, Minarovits J, Batkai L:  J Gravit Physiol. 9: 293-294, 2002. [Abstract]
 
Three-Dimensional Binding of Epidermal Growth Factor Peptides in Colonic Tissues Produced From Rotating Bioreactor.
Kaeffer B, Trubuil A, Kervrann C, Pardini L, Cherbut C:  In Vitro Cell Dev Biol Anim 38: 436- 439, 2002. [Abstract]
 
Proliferation of Human Hematopoietic Bone Marrow Cells in Simulated Microgravity.
Plett PA, Frankovitz SM, Abonour R, Orschell-Traycoff CM; In Vitro Cell Dev Biol Anim 37: 73-78, 2001. [Abstract]
 
Erythroid Cell Growth and Differentiation In Vitro in the Simulated Microgravity Environment of the NASA Rotating Wall Vessel Bioreactor.
Sytkowski AJ and Davis KL; In Vitro Cell Dev Biol Anim 37: 79- 83, 2001. [Abstract]
 
Simulated Microgravity Impairs Respiratory Burst Activity in Human Promyelocytic Cells.
Hughes JH and Long JP; In Vitro Cell Dev Biol Anim 37: 209-215, 2001. [Abstract]
 
Multiple Interleukin-2 Signaling Pathways Differentially Regulated by Microgravity.
Licato LL, Grimm EA; Immunopharmacology 44: 273-9, 1999. [Abstract]
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