Synthecon: 3D Culture Systems for 3D World!
HOMEGALLERYPRODUCTSRESEARCH PUBLICATIONSTECHNICAL RESOURCESNEWS CONTACT USCOMPANYBLOG

Research Publications / Microbiology

Emergence of two distinct subpopulations from Klebsiella pneumoniae grown in the stimulated microgravity environment.
Wang H, Li W1,, Gu L, Gao , Ni B, Deng H, Yang R, Han Y. Future Microbiol. 2017 Sep;12:939-951. doi: 10.2217/fmb-2017-0032. Epub 2017 Aug 17. [Abstract]

Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lungepithelial model and the influence of fetal bovine serum.
Crabbé A1,2, Liu Y2, Matthijs N1, Rigole P1, De La Fuente-Nùñez C3, Davis R2, Ledesma MA2, Sarker S2, Van Houdt R4, Hancock RE3, Coenye T1, Nickerson CA2,5.Sci Rep. 2017 Mar 3;7:43321. doi: 10.1038/srep43321. [Full Text] [Full Text PDF]

Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns
J.Barrila, J. Yang, A. Crabbé, S.F. Sarker, Y. Liu, C.M. Ott, M.A.Nelman-Gonzalez, S. Clemett, S.D. Nydam, R.J. Forsyth, R.R. Davis, B.E. Crucian, H. Quiriarte, K.L. Roland, K. Brenneman, C. Sams, C.Loscher & Cheryl A. Nickerson
npj Microgravity. 2017 Feb 28;3(1):10.doi:10.1038/s41526-017-0011-2 [Full Text] [Full Text PDF]

Human three-dimensional endometrial epithelial cell model to study host interactions with vaginal bacteria and Neisseria gonorrhoeae.
Łaniewski P, Gomez A, Hire G, So M, Herbst-Kralovetz MM.Infect Immun. 2017 Jan 4. pii: IAI.01049-16. doi: 10.1128/IAI.01049-16.  [Abstract]

Effect of Shear Stress on Pseudomonas aeruginosa Isolated from the Cystic Fibrosis Lung.
Dingemans J, Monsieurs P, Yu SH, Crabbé A, Förstner KU, Malfroot A, Cornelis P, Van Houdt R. MBio. 2016 Aug 2;7(4). pii: e00813-16. doi: 10.1128/mBio.00813-16. [Abstract] [Full Text]

Microgravity as a biological tool to examine host-pathogen interactions and to guide development of therapeutics and preventatives that target pathogenic bacteria.
Higginson EE1, Galen JE1, Levine MM2, Tennant SM3. Pathog Dis. 2016 Sep 13. pii: ftw095. [Abstract] [Full Text]

Physiological fluid shear alters the virulence potential of invasive multidrug-resistant non-typhoidal Salmonella Typhimurium D23580
Jiseon Yang, Jennifer Barrila, Kenneth L Roland, C Mark Ott and Cheryl A Nickerson. npj Microgravity 2, Article number: 16021 (2016)
doi:10.1038/npjmgrav.2016.21 [Full Text] [Full Text pdf]

The International Space Station: an Extreme Environment for Key Host-Microbe Discoveries
C. Mark Ott, Thomas Marshburn, and Cheryl A. Nickerson. Microbe—Volume 11, Number 6, 2016, Pages 253-261. [Abstract]

IL-36γ Augments Host Defense and Immune Responses in Human Female Reproductive Tract Epithelial Cells
Sean M. Winkle, Andrea L. Throop and Melissa M. Herbst-Kralovetz. Front. Microbiol., 17 June 2016 | http://dx.doi.org/10.3389/fmicb.2016.00955 [Full Text]

Increased biofilm formation ability in Klebsiella pneumoniae after short-term exposure to a simulated microgravity environment.
Wang H, Yan Y, Rong D, Wang J, Wang H, Liu Z, Wang J, Yang R, Han Y. Microbiologyopen. 2016 May 16. doi: 10.1002/mbo3.370. [Abstract]

A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance.
McConkey CA1, Delorme-Axford E, Nickerson CA, Kim KS, Sadovsky Y, Boyle JP, Coyne CB.Sci Adv. 2016 Mar 4;2(3):e1501462. doi: 10.1126/sciadv.1501462. eCollection 2016. [Abstract] 

Influence of Low-Shear Modeled Microgravity on Heat Resistance, Membrane Fatty Acid Composition, and Heat Stress-Related Gene Expression in Escherichia coli O157:H7 ATCC 35150, 43889, 43890, and 43895.
Kim HW, Rhee MS. Appl Environ Microbiol. 2016 Mar 4. pii: AEM.00050-16.Appl Environ Microbiol. 2016 Mar 4. pii: AEM.00050-16. [Abstract] 

High throughput de novo RNA sequencing elucidates novel responses in Penicillium chrysogenum under microgravity.
Sathishkumar Y, Krishnaraj C, Rajagopal K, Sen D,, Lee YS.Bioprocess Biosyst Eng. 2015 Nov 24. [Abstract]

Effect of Microgravity on Fungistatic Activity of an α-Aminophosphonate Chitosan Derivative against Aspergillus niger
Kesavan Devarayan , Yesupatham Sathishkumar , Yang Soo Lee , Byoung-Suhk Kim, Published: October 15, 2015http://dx.doi.org/10.1371/journal.pone.0139303 [Abstract] [FullText]

From Single Cells to Engineered and Explanted Tissues: New Perspectives in Bacterial Infection Biology.
Bergmann S, Steinert M.Int Rev Cell Mol Biol. 2015;319:1-44. doi: 10.1016/bs.ircmb.2015.06.003. Epub 2015 Jul 21. [Abstract]

Simulated microgravity affects ciprofloxacin susceptibility and expression of acrAB-tolC genes in E. coli ATCC25922.
Xu B, Li C, Zheng Y, Si S, Shi Y, Huang Y, Zhang J, Cui Y, Cui Y.Int J Clin Exp Pathol. 2015 Jul 1;8(7):7945-52. eCollection 2015. [Abstract] [Full Text]

Conservation of the Low-shear Modeled Microgravity Response in Enterobacteriaceae and Analysis of the trp Genes in this Response.
Soni A, O'Sullivan L, Quick LN, Ott C, Nickerson CA, Wilson JW.Open Microbiol J. 2014 Jun 13;8:51-8. doi: 10.2174/1874285801408010051. [Abstract] [Full Text] [Full Text pdf]

Bacteria in the vaginal microbiome alter the innate immune response and barrier properties of the human vaginal epithelia in a species-specific manner.
Doerflinger SY1, Throop AL2, Herbst-Kralovetz MM2.J Infect Dis. 2014 Jun 15;209(12):1989-99. doi: 10.1093/infdis/jiu004. Epub 2014 Jan 7. [Abstract] [Full Text]
The use of a three-dimensional cell culture model to investigate host-pathogen interactions of Francisella tularensis in human lung epithelial cells.David J, Sayer NM, Sarkar-Tyson M.  Microbes Infect. 2014 May 4. pii: S1286-4579(14)00053-7. doi: 10.1016/j.micinf.2014.04.001. [Abstract] 
 
Modeled microgravity cultivation modulates N-acylhomoserine lactone production in Rhodospirillum rubrum S1H independently of cell density.Mastroleo F, Van Houdt R, Atkinson S, Mergeay M, Hendrickx L, Wattiez R, Leys N. Microbiology. 2013 Dec;159(Pt 12):2456-66. doi: 10.1099/mic.0.066415-0. [Abstract]
 
The Effects of Modeled Microgravity on Growth Kinetics, Antibiotic Susceptibility, Cold Growth, and the Virulence Potential of a Yersinia pestis ymoA-Deficient Mutant and Its Isogenic Parental Strain.
Lawal A, Kirtley ML, van Lier CJ, Erova TE, Kozlova EV, Sha J, Chopra AK, Rosenzweig JA.  Astrobiology. 2013 Sep;13(9):821-32. doi: 10.1089/ast.2013.0968. [Abstract]

Mycoplasma genitalium infection activates cellular host defense and inflammation pathways in a 3-dimensional human endocervical epithelial cell model.
McGowin CL, Radtke AL, Abraham K, Martin DH, Herbst-Kralovetz M. 
J Infect Dis. 2013 Jun 15;207(12):1857-68. doi: 10.1093/infdis/jit101. Epub 2013 Mar 14. [Abstract] [Full Text]
 
Impact of simulated microgravity on the normal developmental time line of an animal-bacteria symbiosis.
Foster JS, Khodadad CL, Ahrendt SR, Parrish ML Sci Rep. 2013 Feb 26;3:1340. doi: 10.1038/srep01340. [Abstract] [Full Text] [Full Text pdf]

Microbial products alter the expression of membrane-associated mucin and antimicrobial peptides in a three-dimensional human endocervical epithelial cell model.
Radtke AL, Quayle AJ, Herbst-Kralovetz MM.Biol Reprod. 2012 Dec 6;87(6):132. doi: 10.1095/biolreprod.112.103366. Print 2012 Jun. [Abstract] [Full Text]
 
Microbial Products Alter the Expression of Membrane-Associated Mucin and Antimicrobial Peptides in a 3-D Human Endocervical Epithelial Cell Model.
Radtke AL, Quayle AJ, Herbst-Kralovetz MM.  Biol Reprod. 2012 Oct 10. [Abstract] [Full Text] [Full Text pdf]
 
The effect of low shear force on the virulence potential of Yersinia pestis: new aspects that space-like growth conditions and the final frontier can teach us about a formidable pathogen.
Rosenzweig JA, Chopra AK.Front Cell Infect Microbiol. 2012 Aug 9;2:107. doi: 10.3389/fcimb.2012.00107. [Abstract] [Full Text] [Full Text pdf]
 
Expression of Multiple Stress Response Genes by Escherichia Coli Under Modeled Reduced Gravity.
Vukanti R, Leff LG. J Microgravity Science and Technology. 2012 Sept 1;24(4):267-79. doi: 10.1007/s12217-012-9310-0. [Abstract]
 
Effects of low-shear modeled microgravity on a microbial community filtered through a 0.2-μm filter and its potential application in screening for novel microorganisms.
Aoyagi H, Kuroda A. J Biosci Bioeng. 2012 Jul;114(1):73-9. doi: 10.1016/j.jbiosc.2012.02.021. Epub 2012 May 8. [Abstract]
 
Low-Shear Modeled Microgravity Enhances Salmonella EntericaResistance to Hydrogen Peroxide Through a Mechanism Involving KatG and KatN.
Pacello F, Rotilio G, Battistoni A. Open Microbiol J. 2012;6:53-64 [Abstract] [Full Text] [Full Text pdf]
 
Rotating wall vessel exposure alters protein secretion and global gene expression in Staphylococcus aureus.
Rosado H, O’Neill AJ, Blake KL, Walther M, Long PF, Hinds J, Taylor PW. International Journal of Astrobiology. 2012 Apr;11(2):71-81. doi: 10.1017/S1473550411000346. [Abstract]
 
Involvement of nitric oxide in the mechanism of biochemical alterations induced by simulated microgravity in Microcystis aeruginosa.
Xiao Y, Liu Y, Wang G. Advances in Space Research. 2012 March 1; 49(5):850-8. doi: 10.1016/j.asr.2011.11.003. [Abstract]

New insights into the bacterial fitness-associated mechanisms revealed by the characterization of large plasmids of an avian pathogenic E. coli.
Mellata M, Maddux JT, Nam T, Thomson N, Hauser H, Stevens MP, Mukhopadhyay S, Sarker S, Crabbé A, Nickerson CA, Santander J, Curtiss R 3rd. PLoS One. 2012;7(1):e29481. [Abstract] [Full Text] [Full Text pdf]

Effect of modeled reduced gravity conditions on bacterial morphology and physiology
R Vukanti, MA Model, LG Leff; BMC Microbiol. 2012 Jan 12;12:4.[Abstract] [Full Text] [Full Text pdf]
 
Induction of attachment-independent biofilm formation and repression of Hfq expression by low-fluid-shear culture of Staphylococcus aureus.
Castro S.L., Nelman-Gonzalez M., Nickerson C.A., Ott, C.M. Appl Environ Microbiol. 2011 Sep;77(18):6368-78. [Abstract] [Full Text] [Full Text pdf]
 
Human norovirus infection of caco-2 cells grown as a three-dimensional tissue structure.
Straub TM, Bartholomew RA, Valdez CO, Valentine NB, Dohnalkova A, Ozanich RM, Bruckner-Lea CJ, Call DR. J Water Health. 2011 Jun;9(2):225-40. [Abstract] [Full Text] [Full Text pdf]
 
Responses of haloarchaea to simulated microgravity.
Dornmayr-Pfaffenhuemer M, Legat A, Schwimbersky K, Fendrihan S, Stan-Lotter H. Astrobiology; 11(3):199-205. 2011 [Abstract]
 
Alveolar epithelium protects macrophages from quorum sensing-induced cytotoxicity in a three-dimensional co-culture model.
Crabbé A, Sarker SF, Van Houdt R, Ott CM, Leys N, Cornelis P, Nickerson CA. Cell Microbiol. 2011 Mar;13(3):469-81. doi: 10.1111/j.1462-5822.2010.01548.x. [Abstract]
 
Effects of low-shear modeled microgravity on the characterization of recombinant β-D-glucuronidase expressed in Pichia pastoris.
Qi F, Dai D, Liu Y, Kaleem I, Li C Appl Biochem Biotechnol.; 163(1):162-7, 2011[Abstract]
 
Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen.
Crabbé A, Schurr MJ, Monsieurs P, Morici L, Schurr J, Wilson JW, Ott CM, Tsaprailis G, Pierson DL, Stefanyshyn-Piper H, Nickerson CA. Appl Environ Microbiol. 2011 Feb;77(4):1221-30. [Abstract] [Full Text] [Full Text pdf]
 
Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions.
Barrila J, Radtke AL, Crabbé A, Sarker SF, Herbst-Kralovetz MM, Ott CM, Nickerson CA. Nat Rev Microbiol. 2010 Nov;8(11):791-801 [Abstract]
 
Maintenance of antimicrobial susceptibility of Acinetobacter baumannii in modeled microgravity.
Hensley DM.Clin Lab Sci. 23(2):84-8, 2010 [Abstract]
 
Spaceflight and modeled microgravity effects on microbial growth and virulence.
Rosenzweig JA, Abogunde O, Thomas K, Lawal A, Nguyen YU, Sodipe A, Jejelowo O. Appl Microbiol Biotechnol 85:885-891, 2010 [Abstract] [Full Text] [Full Text pdf]
 
Analysis of Interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells.
Radtke AL, Wilson JW, Sarker S, Nickerson CA. PLoS One 29;5:e15750, 2010 [Abstract] [Full Text] [Full Text pdf]
 
Response of Pseudomonas aeruginosa PAO1 to low shear modeled microgravity involves AlgU regulation.
Crabbe A, Pycke B, Van Houdt R, Monsieurs P, Nickerson C, Leys N, Cornelis P. Environ Microbiol 12:1545- 1564, 2010 [Abstract]
 
Bacillus thuringiensis conjugation in simulated microgravity.
Beuls E, Van Houdt R, Leys Y, Dijkstra C Larkin O, Mahillon J. Astrobiology. 9: 797-805, 2009 [Abstract]
 
Use of the rotating wall vessel technology to study the effect of shear stress on growth behaviour of Pseudomonas aeruginosa PA01.
Crabbé A, De Boever P, Van Houdt R, Moors H, Mergeay M, Cornelis P. Environ Microbiol 10: 2098-2110, 2008 [Abstract]
 
Detection of Epithelial-Cell Injury, and Quantification of Infection, in the HCT-8 Organoid Model of Cryptosporidiosis.
Warren CA, Destura, RV, Sevilleja JEAD, Barroso LF, Carvalho H, Barrett LJ, O’Brien, AD, Guerrant RL.  J Infect Dis 198: 143-149, 2008 [Abstract] [Full Text] [Full Text pdf]
 
Media Ion Composition Controls Regulatory and Virulence Response of Salmonella in Spaceflight. 
Wilson JW ,Ott CM, Quick L, Davis R, Zu Bentrup KH, Crabbe´ A, Richter E, Sarker S, Barrila J, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Shah M, Nelman-Gonzalez M, Hing S, Parra M, Dumars P, Norwood K, Bober R, Devich J, Ruggles A, deBaca AC, Narayan S, Benjamin J, Goulart C, Rupert M, Catella L, Schurr MJ, Buchanan K, Morici L, McCracken J, Porter MD, Pierson DL, Smith SM, Mergeay M, Leys N, Stefanyshyn-Piper HM, Gorie D, Nickerson CA. PLos ONE 3: e3923, 2008 [Abstract] [Full Text] [Full Text pdf]
 
Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq.
Wilson JW, Ott CM, Zu Bentrup KH, Ramamurthy R, Quick L, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Fernandez D, Richter E, Shah WM, Kilcoyne M, Joshi L, Nelman-Gonzalez M, Hing S, Parra M, Dumars P, Norwood K, Bober R, Devich J, Ruggles A, Goulart C, Rupert M, Stodieck L, Stafford P, Catella L, Schurr MJ, Buchanan K, Morici L, McCracken J, Allen P, Baker-Colman C, Hammond T, Vogel J, Nelson R, Pierson DL, Stefanyshyn-Piper HM, Nickerson CA. Proc Natl Acad Sci USA 104: 16299-16304, 2007[Abstract] [Full Text] [Full Text pdf]
 
Studying host-pathogen interactions in 3-D: organotypic models for infectious disease and drug development.
Nickerson CA, Richter EG, Ott CM; J Neuroimmune Pharmacol. 2:26-31, 2007 [Abstract]
 
In vitro Cell Culture Infectivity Assay for Human Noroviruses.
Straub TM, Honer zu Bentrup K, Orosz-Coghlan, P, Dohnalkova A, Mayer BK, Bartholomew RA, Valdez CO, Bruckner-Lea C, Gerba CP, Abbaszadegan M, Nickerson CA,  Emerging Infectious Diseases 13: 396-403, 2007 [Abstract] [Full Text] [Full Text pdf]
 
Characterization of Escherichia coli MG1655 grown in a low shear modeled microgravity environment.
Tucker DL, Ott CM, Huff, S, Fofanov V, Willson RC, Fox GE. BMC Microbiology 7: 15, 2007 [Abstract] [Full Text] [Full Text pdf]
 
A Novel Quantitative Biosystem to Model Physiological Fluid Shear Stress on Cells.
Nauman EA, Ott CM, Sander E, Tucker DL, Pierson D, Wilson JW, Nickerson CA., Appl Environ Microbiol 73:699-705, 2006 [Abstract] [Full Text] [Full Text pdf]
 
Novel three-dimensional organoid model for evaluation of the interaction of uropathologenic Escherichia coli with terminally differentiated human urothelial cells.
Smith YC, Grande KK, Rasmussen SB, O’Brien AD.;  Infect. Immun. 74: 750-757, 2006 [Abstract] [Full Text] [Full Text pdf]
 
Escherichia coli biofilms formed under low-shear modeled microgravity in a ground-based system.
Lynch SV, Mukundakrishnan K, Benoit MR, Ayyaswamy PS, Matin A;. Appl. Environ. Microbiol. 72: 7701-7710, 2006 [Abstract] [Full Text] [Full Text pdf]
 
Three-dimensional organotypic models of human colonic epithelium to study the early stages of enteric salmonellosis.
Honer Zu Bentrup K, Ramamurthy R, Ott CM, Emami K, Nelman-Gonzalez M, Wilson JW, Richter EG, Goodwin TJ, Alexander JS, Pierson DL, Pellis N, Buchanan KL, Nickerson CA. Microbes Infect. 8: 1813-182, 2006. [Abstract]
 
A three-dimensional tissue culture model for the study of attach and efface lesion formation by enteropathic and enterohaemorrhagic Escherichia coli.
CCarvalho HM, Teel LD, Goping G, O’Brien AD: ell Microbiol 7: 1771-1781, 2005. [Abstract]
 
A549 Lung Epithelial Cells Grown as Three-Dimensional Aggregates: Alternative Tissue Culture Model for Pseudomonas Aeruginosa Pathogenesis.
Carterson AJ, Honer zu Bentrup K, Ott CM, Clarke MS, Pierson DL, Vanderburg CR, Buchanan KL, Nickerson CA, Schurr MJ:Infect Immun 73: 1129-1140, 2005. [Abstract] [Full Text] [Full Text pdf]
 
Invasion of Human Tissue Ex Vivo by Borrelia:
Duray P, Yin S, Ito Y, Bezrukov L, Cox C, Cho M, Fitzgerald W: Journal of infectious Diseases 191:1747-1754 2005 [Abstract] [Full Text] [Full Text pdf] 
 
A Potential Cause for Kidney Stone Formation During Space Flights: Enhanced Growth of Nanobacteria in Microgravity.
Ciftcioglu N, Haddad RS, Golden DC, Morrison DR, McKay DS: Kidney Int. 67: 483- 491, 2005. [Abstract]
 
Three-Dimensional Growth of Extravillous Cytotrophoblasts Promotes Differentiation and Invasion.
LaMarca H.L, Ott C.M, Höner zu Bentrup K, LeBlanc C.L, Pierson D.L, Nelson A.B, Scandurro A.B, Whitley G.St.J, Nickerson C.A, and C.A.Morris: Placenta 26::709-720, 2005 [Abstract]
 
Role and Regulation of Sigma S in General Resistance Conferred by Lowshear Simulated Microgravity in Escherichia Coli. Lynch SV, Brodie EL, Matin A: J Bacteriol 186: 8207-8212, 2004. [Abstract] [Full Text] [Full Text pdf]
 
Microbial Responses to Microgravity and Other Low-Shear Environments.
Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, Pierson DL:Microbiol Mol Biol Rev Jun; 68: 345-61, 2004. [Abstract] [Full Text] [Full Text pdf]
 
A New Dimension in Modeling Infectious Disease.
Nickerson CA, Ott CM: ASM News 70: 169-175, 2004. [Full Text pdf]
 
Growth and Membrane Polarization in Pseudomonas aeruginosa UG2 Grown in Randomized Microgravity in a High Aspect Ratio Vessel.
England LS, Gorzelak M, Trevors JT: Biochimica et Biophysica Acta 1624: 76- 81, 2003. [Abstract]
 
Low-Shear Modeled Microgravity: A Global Environmental Regulatory Signal Affecting Bacterial Gene Expression
Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, LeBlanc CL,et al.: Physiology, and Pathogenesis. Journal of Microbiological Methods 54:1-11, 2003. [Abstract]
 
Low-Shear Modeled Microgravity Alters the Salmonella Enterica Serovar Typhimurium Stress Response in an RpoSindependent Manner. Wilson JW, Ott CM, Ramamurthy R, Porwollik S, McClelland M, Pierson DL, Nickerson CA. Applied and Environmental Microbiology 68:5408-5416, 2002. [Abstract] [Full Text] [Full Text pdf]
 
Microarray Analysis Identifies Salmonella Genes Belonging to the Low-Shear Modeled Microgravity Regulon
Wilson JW, Ramamurthy R, Porwollik S, McClelland M, Hammond T, Allen P, Ott CM, Pierson DL, Nickerson CA:  Proc. Natl. Acad. Sci. USA 99: 13807-13812, 2002  [Abstract] [Full Text] [Full Text pdf]
 
Secondary Metabolism in Simulated Microgravity
Demain AL and Fang A: Chem Rec 1: 333-346, 2001. [Abstract]
 
Shear Stress Enhances Microcin B17 Production in a Rotating Wall Bioreactor, But Ethanol Does Not.
Gao Q, Fang A, Pierson DL, Mishra SK, Demain AL: Appl Microbiol Biotechnol 56: 384-387, 2001. [Abstract]
 
Three-Dimensional Tissue Assemblies: Novel Models for the Study of Salmonella Enterica Serovar Typhimurium Pathogenesis.
Nickerson CA, Goodwin TJ, Terlonge J, Ott CM, Buchanan KL, Uicker WC, Emami K, LeBlanc C, Ramamurthy R, Clarke MS, Vanderburg CR, Hammond T, Pierson DL: Infect Immun 69: 7106-7120, 2001. [Abstract] [Full Text] [Full Text pdf]
 
Microgravity as a Novel Environmental Signal Affecting Microbial Virulence.
Nickerson CA, Ott M, Mister SJ, Morrow BJ, Burns-Keliher L, Pierson DL: Infect. Immun. 68: 3147-3150, 2000. [Abstract] [Full Text] [Full Text pdf]
 
Relief from Glucose Interference in Microcin B17 Biosynthesis by Growth in a Rotating-Wall Bioreactor.
Fang A, Pierson DL, Mishra SK, Demain AL: Lett Appl Microbiol 31: 39-41, 2000. [Abstract]
 
Effect of Simulated Microgravity and Shear Stress on Microcin B17 Production by Escherichia Coli and on its Excretion into the Medium.
Fang A, Pierson DL, Koenig DW, Mishra SK, and Demain AL: Appl Environ Microbiol 63: 4090-4092, 1997. [Abstract] [Full Text] [Full Text pdf]
 
Gramicidin S Production by Bacillus Brevis in Simulated Microgravity.
Fang A., Pierson DL, Mishra SK, Koenig DW and Demain AL: Curr Microbiol 34: 199-204, 1997. [Abstract]
 
Secondary Metabolism in Simulated Microgravity: B-Lactam Production by Streptomyces Clavuligerus.
Fang A, Pierson DL, Mishra SK, Koenig DW and Demain AL: J Ind Microbiol Biotechnol 18: 22-25, 1997 [Abstract]
Single Use 3D BioreactorsAutoclavable 3D BioreactorsStem Cell Culture SystemsPerfusion Bioreactors Nanobiomatrix ScaffoldsBiostructure Matrix Scaffolds
Synthecon, Incorporated | 8977 Interchange Dr. | Houston, Texas 77054 | (713) 741-2582 | Toll Free (800) 853-0740
Website by SinyakCreative
© 2018 Synthecon, Incorporated, All Rights Reserved