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Research Publications / Miscellaneous

Regulation of the Response of Caenorhabditis elegans to Simulated Microgravity by p38 Mitogen-Activated Protein Kinase Signaling.
Li W, Wang D, Wang D. Sci Rep. 2018 Jan 16;8(1):857. doi: 10.1038/s41598-018-19377-z. [Full Text]

Effect of Microgravity on Fungistatic Activity of an α-Aminophosphonate Chitosan Derivative against Aspergillus niger
Kesavan Devarayan , Yesupatham Sathishkumar , Yang Soo Lee , Byoung-Suhk Kim, Published: October 15, 2015 [Abstract] [FullText]

Growth and Metabolism of the Green Alga, Chlorella Pyrenoidosa, in Simulated Microgravity 
Mills W.R. Pierson D.L. NASA Technical Report; 2000, NASA/JSC Life Sciences Research Laboratories Final Report 
[Abstract] [Full Text pdf]

Assessing cisplatin-induced ototoxicity and otoprotection in whole organ culture of the mouse inner ear in simulated microgravity. Tropitzsch A, Arnold H, Bassiouni M, Müller A, Eckhard A, Müller M, Löwenheim H. Toxicol Lett. 2014 Apr 5. pii: S0378-4274(14)00144-1. doi: 10.1016/j.toxlet.2014.03.022. [Abstract] [Full Text] [Full Text pdf]

Ex-Vivo Dynamic 3-D Culture of Human Tissues in the RCCS™ Bioreactor Allows the Study of Multiple Myeloma Biology and Response to Therapy. 
Ferrarini M, Steimberg N, Ponzoni M, Belloni D, Berenzi A, Girlanda S, Caligaris-Cappio F, Mazzoleni G, Ferrero E. PLoS One. 2013 Aug 26;8(8):e71613. doi: 10.1371/journal.pone.0071613. [Abstract] [Full Text] 
Rotary culture promotes the proliferation of MCF-7 cells encapsulated in three-dimensional collagen-alginate hydrogels via activation of the ERK1/2-MAPK pathway. Zheng H, Tian W, Yan H, Yue L, Zhang Y, Han F, Chen X, Li Y. Biomed Mater. 2012 Feb;7(1):015003. doi: 10.1088/1748-6041/7/1/015003. [Abstract]
Rotating cell culture systems for human cell culture: human trophoblast cells as a model. Zwezdaryk KJ, Warner JA, Machado HL, Morris CA, Höner zu Bentrup K. J Vis Exp. 2012 Jan 18;(59). pii: 3367. doi: 10.3791/3367. [Abstract]
Effects of Simulated Microgravity on Expression Profile of MicroRNA in Human Lymphoblastoid Cells. Mangala LS, Zhang Y, He Z, Emami K, Ramesh GT, Story M, Rohde LH, Wu H. J Biol Chem. 286(37):32483-90, 2011 [Abstract]
Simulated microgravity, erythroid differentiation, and the expression of transcription factor GATA-1 in CD34+ cells.
Zheng L, Liu JZ, Hu YW, Zhong TY, Xiong SL, Wang W, Wang Q. Aviat Space Environ Med. 82(5):513-7, 2011 [Abstract]
Simulated microgravity-induced epigenetic changes in human lymphocytes.
Singh KP, Kumari R, Dumond JW. J Cell Biochem. 111(1):123-9, 2010 [Abstract]
Xenopus development from late gastrulation to feeding tadpole in simulated microgravity.
Olson WM, Wiens DJ, Gaaul TL, Rodriguez M, Hauptmeier CL.  Intl J Dvl Biol. ;54:167-74. [Abstract][Full Text pdf]
Cultivation of Lacrimal gland acinar cells in a microgravity environment.
Schrader S, Kremling C, Clinger M, Lagua H, Geerling G.  Br J Ophthalmol. 93: 1121-1125, 2009 [Abstract]
Oxygen transport and consumption by suspended cells in microgravity: A multiphase analysis.
Kwon O, Devarakonda SB, Sankovic JM, Banerjee RK.  Biotechnol Bioeng 99:99-107, 2008 [Abstract]
In situ monitoring of 3D in vitro cell aggregation using an optical imaging system.
Sawyer N, Worrall L, Crowe J, Waters, S, Shakesheff K, Rose F, Morgan S.  Biotechnol Bioeng 100:159-167, 2007 [Abstract]
Morphological characteristics and proliferation of keratocytes cultured under simulated microgravity.
Chen J, Chen R, Gao S.  Artif Organs 31: 722-731, 2007 [Abstract]
Does reduced gravity alter cellular responses to ionizing radiation?
Manti L. Radiat Environ Biophys 45: 1-8, 2006 [Abstract]
Nitric oxide affects preimplantation embryonic development in a rotating wall vessel bioreactor simulating microgravity. Cao YJ, Fan XJ, Shen Z, Ma BH, Duan EK.  Cell Biol. Int. 31: 24-29, 2007 [Abstract]
Gene expression and survival changes in Saccharomyces cerevisiae during suspension culture.
Johanson K, Allen PL, Gonzalez-Villalobos RA, Baker CB, D'Elia R, Hammond TG.: Biotechnol Bioeng 93: 1050-1059, 2006 [Abstract]
Changes in gravitational force affect gene expression in developing organ systems at different developmental times.
Shimada N, Sokunbi G, Moorman SJ:  BMC Dev Biol 5: 10 , 2005. [Abstract] [Full Text] [Full Text pdf]
Morin Sulphates/Glucuronides Enhance Macrophage Function in Microgravity Culture System.
Hsieh C, Chao P, Fang S,:  European Journal of Clinical Investigation 35, 591-596, 2005 [Abstract]
“Modeled Microgravity” Affects Cell Response to Ionizong Radiation and Increase Genomic Damage.
Canova S, Fiorasi F, Mognato M, Grifalconi M, Reddi E, Russo A, Celotti L: Radiat Res 163: 191-199, 2005.[Abstract]
Continuous Glucose Monitoring and Control in a Rotating Wall Perfused Bioreactor.
Xu Y, Sun J, Mathew G, Jeevarajan AS, Anderson MM: Biotechnol Bioeng. 86: 473-477, 2004.[Abstract]
Long-Term Continuous Monitoring of Dissolved Oxygen in Cell Culture Medium for Perfused Bioreactors Using Optical Oxygen Sensors.
Gao FG, Jeevarajan AS, Anderson MM: Biotechnol Bioeng. 86: 425-433, 2004.[Abstract]
Increase in Synthesis of Human Monoclonal Antibodies by Transfected Sp2/0 Myeloma Mouse Cell Line Under Conditions of Microgravity.
Foster LJ, Catzel D, Atwa S, Zarka M, Mahler SM:  Biotechnol Lett. Aug. 25: 1271-1274, 2003. [Abstract]
Simulated Conditions Of Microgravity Suppress Progesterone Production by Luteal Cells of the Pregnant Rat.
Bhat GK, Yang H, Sridaran R:  J Gravit Physiol Dec; 8: 57-66, 2001. [Abstract]
Monitoring and Controlling the Dissolved Oxygen (DO) Concentration Within the High Aspect Ration Vessel (HARV).
Saarinen MA, Reece JS, Arnold MA, Murhammer DW:  Biotechnol. Prog. 19; 1335-1341, 2003. [Abstract]
RWPV Bioreactor Mass Transport: Earth-Based and in Microgravity.
Begley CM, Kleis SJ:  Biotechnol Bioeng, 80: 465-76, 2002. [Abstract]
A Countermeasure to Ameliorate Immune Dysfunction in In Vitro Simulated Microgravity Environment: Role of Cellular Nucleotide Nutrition.
Hales NW, Yamauchi K, Martinez AA, Sundaresan A, Pellis NR and Kulkarni AD: In Vitro Cell Dev Biol (Animal) 38(4):213-217, 2002. [Abstract]
Space Immunology and Countermeasure Research in Modeled Microgravity. Kulkarni AD, Yamauchi K. Taga M, Savary CA, Sundaresan A and Pellis NR:  Proceedings of the Aerospace Sciences and Conference, AIAA-2002-0325:1-6, 2002. 
On-Line Measurement of Glucose in a Rotating Wall Perfused Vessel Using an Amperometric Glucose Sensor.
Yuanhang Xu, Antony S. Jeevarajan, James M. Gay, Thomas D Taylor, Melody M. Anderson:  J The Electrochemical Society, 149: H103- H106, 2002 [Abstract pdf]
Continuous pH Monitoring in a Perfused Bioreactor System Using an Optical pH Sensor.
Jeevarajan AS, Vani S, Taylor TD, Anderson MM:  Biotechnol Bioeng 78: 467-472, 2002. [Abstract]
A Critical Period for Functional Vestibular Development in Zebrafish.
Moorman SJ, Cordova R, Davies SA:  Dev Dyn 223: 285-291, 2002. [Abstract] [Full Text] [Full Text pdf]
Nutrition Countermeasure and Immune Function in Microgravity. Kulkarni AD, Yamauchi K. and Pellis NR.  Proceedings of the 2nd Pan Pacific Basin Workshop on Microgravity Sciences, Pasadena, CA. April 2001BT1099:1-10, 2001.[Abstract]
NASA Biotechnology: Cell Science in Microgravity. Jessup JM, and Pellis NR:  In Vitro Cell Dev Biol Anim 37: 2 p preceding 63, 2001.[PubMed ID:11332737]
The Fluid Dynamic and Shear Environment in The NASA/JSC Rotating-Wall Perfused Vessel Bioreactor.
Begley CM and Kleis SJ:  Biotechnol Bioeng 70: 32-40, 2000. [Abstract]
Numerical Model and Experimental Validation of Microcarrier Motion in a Rotating Bioreactor.
Pollack SR, Meaney DF, Levine EM, Litt M, Johnston ED:  Tiss Engin 6: 519-530, 2000. [Abstract]
Membrane Potential Mediates H+-ATPase Dependence of “Degradative Pathway” Endosomal Fusion.
Hammond T, Gonda F, Navar G, Campbell W, Majewski R, Galvan D, Pontillion F, Kaysen J, Goodwin T, Paddock S and Verroust P:  J Memb Biol 162: 157-167, 1998. [Abstract]
Advances in Cellular Construction.
Spaulding GF, Jessup JM and Goodwin TJ:  J Cell Biochem 51: 249-251, 1993 [PubMed ID: 8501125]
Responses Of Gravity Level Variations On The NASA JSC Bioreactor System. 
Tsao YD, Goodwin TJ, Wolf DA, Spaulding GF:  Physiologist 35: Suppl S49-50, 1992.[PubMed ID: 1589533]
Cell Culture for Three-Dimensional Modeling in Rotating Wall Vessels: An Application of Simulated Microgravity
Schwarz RP, Goodwin TJ, Wolf DA: . J Tissue Culture Methods 14: 51-58, 1992. [Abstract]
Analysis of Gravity-Induced Particle Motion and Fluid Perfusion Flow in the NASADesigned Rotating Zero-Head-Space Tissue Culture Vessel.
Wolf DA, Schwarz RP:  NASA Technical Paper 3143, October, 1991. [Abstract]
The Physical Basis of Gravity Stimulus Nullification by Clinostat Rotation.
Dedolph RR and Dipert MH:  Plant Physiol 47: 756-764, 1971. [Abstract] [Full Text] [Full Text pdf]
Modulation of Human Endothelial Cell Behavior in Simulated Microgravity.
Carrlsson SI, Bertilaccio MT, Ascari I, Bradamante S, Maier JA. J Gravit Physiol 9: P273-274, 2002. [Abstract]
Comparative Effectiveness of a Clinostat and a Slow-Turning Lateral Vessel at Mimicking the Ultrastructural Effects of Microgravity in Plant Cells. Moore R. Ann Bot (Lond). 66: 541-549, 1990. [Abstract]
Simulated Weightlessness in the Design and Exploitation of a NMR-Compatible Bioreactor.
Bradamante S, Barenghi L, Villa A. Biotechnol Prog. 20: 1454-1459, 2004.
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