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Research Publications / Newest Releases

Proteasome inhibition suppress microgravity elevated RANK signaling during osteoclast differentiation. Ethiraj P, Ottinger AM, Singh T, Singh A, Haire KM, Reddy SV.  Cytokine. 2019; 125:154821.   [Abstract]

Prolonged exposure to simulated microgravity diminishes dendritic cell immunogenicity. Tackett N, Bradley JH, Moore EK, Baker SH, Minter SL, DiGiacinto B, Arnold JP, Gregg RK. Sci Rep. 2019; 9(1):13825.  [Abstract]

Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP. Arun RP, Sivanesan D, Patra B, Varadaraj S, Verma RS. Sci Rep. 2019; 9(1):10684.  [Full Text]

Muscle Atrophy Marker Expression Differs between Rotary Cell Culture System and Animal Studies. Harding CP, Vargis E.
Biomed Res Int. 2019; 2019:2042808   [Full Text]

Impact of Pristine Graphene on Intestinal Microbiota Assessed Using a Bioreactor-Rotary Cell Culture System. Lahiani MH, Gokulan K, Williams K, Khare S.  ACS Appl Mater Interfaces. 2019;11(29):25708-25719. [Abstract]

Analysis of Host Responses to Neisseria gonorrhoeae Using a Human Three-Dimensional Endometrial Epithelial Cell Model.
Łaniewski P,  Herbst-Kralovetz MM.  Methods Mol Biol. 2019;1997:347-361. [Abstract]

The dynamic adaptation of primary human endothelial cells to simulated microgravity. Cazzaniga A, Locatelli L, Castiglioni S, Maier JAM.   FASEB J. 2019;33(5):5957-5966.  [Abstract]

Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells following transfection with Indian hedgehog and sonic hedgehog using a rotary cell culture system.  Chen L, Liu G, Li W, Wu X.   Cell Mol Biol Lett. 2019; 24:16. [Abstract]

Generation of Vestibular Tissue-Like Organoids From Human Pluripotent Stem Cells Using the Rotary Cell Culture System.
Lim R, Drury H, Nasr B, Li Z, Tadros MA, D'Abaco GM, Stok KS, Nayagam BA, Dottori M.Mattei C.  Front Cell Dev Biol. 2019; 7:25  [Abstract]

Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells. Costantini D, Overi D, Casadei L, Cardinale V, Nevi L, Carpino G, Di Matteo S, Safarikia S, Valerio M, Melandro F, Bizzarri M, Manetti C, Berloco PB, Gaudio E, Alvaro D. Sci Rep. 2019; 9(1):5559. [Full Text]

Rotational culture and integration with amniotic stem cells reduce porcine islet immunoreactivity in vitro and slow xenorejection in a murine model of islet transplantation.  Zafar A, Lee J,  Yesmin S, Paget MB, Bailey CJ, Murray, HE, Downing R. Xenotransplantation 2019; e12508  [Abstract]

Novel Antibiotic Testing Approaches Reveal Reduced Antibiotic Efficacy Against Shiga Toxin-Producing Escherichia coli O157:H7 Under Simulated Microgravity.  Kim HW and Rhee MS.  Front Microbiol. 2018; 9:3214  [Abstract]

Characterization of Gastrospheres Using 3D Coculture System. do Nascimento Santos CA, Borojevic R, Nasciutti LE, Maedatakiya CM.  Methods Mol Biol. 2018;1842:105-121​  [Abstract]

Differential expression profiles of long non‑coding RNAs during the mouse pronuclear stage under normal gravity and simulated microgravity. Feng M, Dang N, Bai Y, Wei H, Meng L, Wang K, Zhao Z, Chen Y, Gao F, Chen Z, Li L, Zhang S. Mol Med Rep. 2019; 19(1):155-164. [Abstract]

Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes
of Age.  Barrila J, Crabbé A, Yang J, Franco K, Nydam SD, Forsyth RJ, Davis RR, Gangaraju S, Ott M, Coyne, CB, Bissell MJ, Nickerson CA. Infection and Immunity 2018; 86(11): e00282-18.  [Abstract]

Osteogenic differentiation of encapsulated rat mesenchymal stem cells inside a rotating microgravity bioreactor: in vitro and in vivo evaluation. Koç Demir A, Elçin AE, Elçin YM. Cytotechnology. 2018;70(5):1375-1388. [Abstract]

Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of
osteoinhibition.  McNeill EP,  Reese RW,  Tondon A, Clough BH, Pan S, Froese J, Palmer D, Krause U, Loeb DM, Kaunas R and Gregory CA. Cell Death and Disease  2018; 9:1161 [Abstract]

Synergistic Effects ofWeightlessness, Isoproterenol, and Radiation on DNA Damage Response and Cytokine Production in Immune Cells. Moreno-Villanueva M, Feiveson AH,  Krieger S, Brinda AK, von Scheven G,  Bürkle A , Crucian B and Wu H. Int. J. Mol. Sci. 2018; 19: 3689 [Abstract]

Effects of Human Cranial Bone-Derived Mesenchymal Stem Cells in Traumatic Brain Injury.  Otsuka T, Imura T, Nakagawa K, Shrestha L, Takahashi S, Kawahara Y, Sueda T, Kurisu K, Yuge L.  Stem Cells Dev. 2018 27(18):1287-1297. [Abstract]

Functional tissue-engineered microtissue derived from cartilage extracellular matrix for articular cartilage regeneration. Yin H, Wang Y, Sun X, Cui G, Sun Z, Chen P, Xu Y, Yuan X, Meng H, Xu W, Wang A, Guo Q, Lu S, Peng J. Acta Biomater. 2018  S1742-7061(18)30425-2. [Abstract]

Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells. Yamashita T, Takayama K, Sakurai F, Mizuguchi H.  Biochem Biophys Res Commun. 2018 496(4):1269-1275. [Abstract]

An integrated biomanufacturing platform for the large-scale expansion and neuronal differentiation of human pluripotent stem cell-derived neural progenitor cells. Srinivasan G, Morgan D, Varun D, Brookhouser N, Brafman DA. Acta Biomater. 2018 74:168-179. [Abstract]

Effects of collagen matrix and bioreactor cultivation on cartilage regeneration of a full-thickness critical-size knee joint cartilage defects with subchondral bone damage in a rabbit model. Wang KH, Wan R, Chiu LH, Tsai YH, Fang CL, Bowley JF, Chen KC, Shih HN, Lai WT. PLoS One;13(5):e0196779 [Full Text]

In Vitro Growth of Mouse Preantral Follicles Under Simulated Microgravity.
Zhang S, Wu Y, Weng Y, Xu Z, Chen W, Zheng D, Lin W, Liu J, Zhou Y. 
J Vis Exp. 2017 Dec 17;(130). doi: 10.3791/55641. [Full Text]

Simulated microgravity impairs cardiac autonomic neurogenesis from neural crest cells.
Hatzistergos KE, Jiang Z, Valasaki K, Takeuchi LM, Balkan W, Atluri P, Saur D, Seidler B, Tsinoremas N, DiFede D, Hare JM.Stem Cells Dev. 2018  27(12): 819-830.  [Abstract]

Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors.
DiStefano T, Chen HY, Panebianco C, Kaya KD, Brooks MJ, Gieser L, Morgan NY, Pohida T, Swaroop A. Stem Cell Reports. 2018 10(1):300-313. [Full Text]

Regulation of the Response of Caenorhabditis elegans to Simulated Microgravity by p38 Mitogen-Activated Protein Kinase Signaling.
Li W, Wang D, Wang D. Sci Rep. (2018) 8(1):857. [Full Text]

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