Synthecon: 3D Culture Systems for 3D World!

Research Publications / Newest Releases

Rotational culture and integration with amniotic stem cells reduce porcine islet immunoreactivity in vitro and slow xenorejection in a murine model of islet transplantation.  Zafar A, Lee J,  Yesmin S, Paget MB, Bailey CJ, Murray, HE, Downing R. Xenotransplantation 2019; e12508  [Abstract]

Novel Antibiotic Testing Approaches Reveal Reduced Antibiotic Efficacy Against Shiga Toxin-Producing Escherichia coli O157:H7 Under Simulated Microgravity.  Kim HW and Rhee MS.  Front Microbiol. 2018; 9:3214  [Abstract]

Differential expression profiles of long non‑coding RNAs during the mouse pronuclear stage under normal gravity and simulated microgravity. Feng M, Dang N, Bai Y, Wei H, Meng L, Wang K, Zhao Z, Chen Y, Gao F, Chen Z, Li L, Zhang S. Mol Med Rep. 2019; 19(1):155-164. [Abstract]

Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes
of Age.  Barrila J, Crabbé A, Yang J, Franco K, Nydam SD, Forsyth RJ, Davis RR, Gangaraju S, Ott M, Coyne, CB, Bissell MJ, Nickerson CA. Infection and Immunity 2018; 86(11): e00282-18.  [Abstract]

Osteogenic differentiation of encapsulated rat mesenchymal stem cells inside a rotating microgravity bioreactor: in vitro and in vivo evaluation. Koç Demir A, Elçin AE, Elçin YM. Cytotechnology. 2018;70(5):1375-1388. [Abstract]

Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of
osteoinhibition.  McNeill EP,  Reese RW,  Tondon A, Clough BH, Pan S, Froese J, Palmer D, Krause U, Loeb DM, Kaunas R and Gregory CA. Cell Death and Disease  2018; 9:1161 [Abstract]

Synergistic Effects ofWeightlessness, Isoproterenol, and Radiation on DNA Damage Response and Cytokine Production in Immune Cells. Moreno-Villanueva M, Feiveson AH,  Krieger S, Brinda AK, von Scheven G,  Bürkle A , Crucian B and Wu H. Int. J. Mol. Sci. 2018; 19: 3689 [Abstract]

Effects of Human Cranial Bone-Derived Mesenchymal Stem Cells in Traumatic Brain Injury.  Otsuka T, Imura T, Nakagawa K, Shrestha L, Takahashi S, Kawahara Y, Sueda T, Kurisu K, Yuge L.  Stem Cells Dev. 2018 27(18):1287-1297. [Abstract]

Functional tissue-engineered microtissue derived from cartilage extracellular matrix for articular cartilage regeneration. Yin H, Wang Y, Sun X, Cui G, Sun Z, Chen P, Xu Y, Yuan X, Meng H, Xu W, Wang A, Guo Q, Lu S, Peng J. Acta Biomater. 2018  S1742-7061(18)30425-2. [Abstract]

Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells. Yamashita T, Takayama K, Sakurai F, Mizuguchi H.  Biochem Biophys Res Commun. 2018 496(4):1269-1275. [Abstract]

An integrated biomanufacturing platform for the large-scale expansion and neuronal differentiation of human pluripotent stem cell-derived neural progenitor cells. Srinivasan G, Morgan D, Varun D, Brookhouser N, Brafman DA. Acta Biomater. 2018 74:168-179. [Abstract]

Effects of collagen matrix and bioreactor cultivation on cartilage regeneration of a full-thickness critical-size knee joint cartilage defects with subchondral bone damage in a rabbit model. Wang KH, Wan R, Chiu LH, Tsai YH, Fang CL, Bowley JF, Chen KC, Shih HN, Lai WT. PLoS One;13(5):e0196779 [Full Text]

In Vitro Growth of Mouse Preantral Follicles Under Simulated Microgravity.
Zhang S, Wu Y, Weng Y, Xu Z, Chen W, Zheng D, Lin W, Liu J, Zhou Y. 
J Vis Exp. 2017 Dec 17;(130). doi: 10.3791/55641. [Full Text]

Simulated microgravity impairs cardiac autonomic neurogenesis from neural crest cells.
Hatzistergos KE, Jiang Z, Valasaki K, Takeuchi LM, Balkan W, Atluri P, Saur D, Seidler B, Tsinoremas N, DiFede D, Hare JM.Stem Cells Dev. 2018  27(12): 819-830.  [Abstract]

Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors.
DiStefano T, Chen HY, Panebianco C, Kaya KD, Brooks MJ, Gieser L, Morgan NY, Pohida T, Swaroop A. Stem Cell Reports. 2018 10(1):300-313. [Full Text]

Regulation of the Response of Caenorhabditis elegans to Simulated Microgravity by p38 Mitogen-Activated Protein Kinase Signaling.
Li W, Wang D, Wang D. Sci Rep. 2018 Jan 16;8(1):857. doi: 10.1038/s41598-018-19377-z. [Full Text]

Modeling Multiple Myeloma-Bone Marrow interactions and response to drugs in a 3D surrogate microenvironment.
Belloni D1, Heltai S, Ponzoni M, Villa A, Vergani B, Pecciarini L, Marcatti M, Girlanda S, Tonon G, Ciceri F, Caligaris-Cappio F, Ferrarini M, Ferrero E. Haematologica. 2018 Jan 11. pii: haematol.2017.167486. doi: 10.3324/haematol.2017.167486. [Full Text]

Advanced 3D models culture to investigate mesenchymal stromal cells of the human dental follicle.
Steimberg N, Angiero F, Farronato D, Berenzi A, Cossellu G, Ottonello A, Kaigler D, Mazzoleni G.Tissue Eng Part C Methods. 2018 Jan 12. doi: 10.1089/ten.TEC.2017.0428. [Abstract]

Genome-wide analysis and prediction of functional long noncoding RNAs in osteoblast differentiation under simulated microgravity. Hu Z, Wang H, Wang Y, Zhou H, Shi F, Zhao J, Zhang S, Cao X.
Mol Med Rep. 2017 Dec;16(6):8180-8188. doi: 10.3892/mmr.2017.7671. [Full Text]

T cell resistance to activation by dendritic cells requires long-term culture in simulated microgravity.
Bradley JH, Stein R, Randolph B, Molina E, Arnold JP, Gregg RK. Life Sci Space Res (Amst). 2017 Nov;15:55-61. doi: 10.1016/j.lssr.2017.08.002. Epub 2017 Aug 8. [Abstract]

Combined Effects of Simulated Microgravity and Radiation Exposure on Osteoclast Cell Fusion.
Shanmugarajan S, Zhang Y, Moreno-Villanueva M, Clanton R, Rohde LH, Ramesh GT, Sibonga JD, Wu H.Int J Mol Sci. 2017 Nov 18;18(11). pii: E2443. doi: 10.3390/ijms18112443. [Full Text]

Coculture of meniscus cells and mesenchymal stem cells in simulated microgravity.
Weiss WM, Mulet-Sierra A, Kunze M, Jomha NM, Adesida AB.NPJ Microgravity. 2017 Nov 10;3:28. doi: 10.1038/s41526-017-0032-x. eCollection 2017. [Full Text]

Emergence of two distinct subpopulations from Klebsiella pneumoniae grown in the stimulated microgravity environment.
Wang H, Li W1,, Gu L, Gao , Ni B, Deng H, Yang R, Han Y. Future Microbiol. 2017 Sep;12:939-951. doi: 10.2217/fmb-2017-0032. Epub 2017 Aug 17. [Abstract]

Effect Of Microgravity On Aromatase Expression In Sertoli Cells.
Cirelli E1, De Domenico E, Botti F, Massoud R, Geremia R, Grimaldi P. Sci Rep. 2017 Jun 14;7(1):3469. doi: 10.1038/s41598-017-02018-2. [Abstract]

Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy.
Devarasetty M1, Wang E, Soker S, Skardal A.
Biofabrication. 2017 Jun 7;9(2):021002. doi: 10.1088/1758-5090/aa7484. [Abstract] 

Effect of microgravity on the mesenchymal stem cell characteristics of limbal fibroblasts.
Pao SI, Chien KH, Lin HT, Tai MC, Chen JT, Liang CM. J Chin Med Assoc. 2017 May 18. pii: S1726-4901(17)30109-0. doi: 10.1016/j.jcma.2017.01.008. [Abstract] [Full Text]

U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis.
Caccuri F, Ronca R, Laimbacher AS, Berenzi A, Steimberg N, Campilongo F, Mazzuca P, Giacomini A, Mazzoleni G, Benetti A, Caselli E, Presta M, Di Luca D, Fraefel C, Caruso A.
Oncotarget. 2017 May 11. doi: 10.18632/oncotarget.17817. [Abstract]

Direct orthotopic implantation of hepatic organoids.
Zhou VX, Lolas M, Chang TT.J Surg Res. 2017 May 1;211:251-260. doi: 10.1016/j.jss.2016.12.028. Epub 2016 Dec 29. [Abstract]

Aligned Nanofibrous Cell-Derived Extracellular Matrix for Anisotropic Vascular Graft Construction.
Xing Q, Qian Z, Tahtinen M, Yap AH, Yates K, Zhao F.Adv Healthc Mater. 2017 May;6(10). doi: 10.1002/adhm.201601333. Epub 2017 Feb 9. [Abstract]

Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lungepithelial model and the influence of fetal bovine serum.
Crabbé A1,2, Liu Y2, Matthijs N1, Rigole P1, De La Fuente-Nùñez C3, Davis R2, Ledesma MA2, Sarker S2, Van Houdt R4, Hancock RE3, Coenye T1, Nickerson CA2,5.Sci Rep. 2017 Mar 3;7:43321. doi: 10.1038/srep43321. [Full Text] [Full Text PDF]

Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns
J.Barrila, J. Yang, A. Crabbé, S.F. Sarker, Y. Liu, C.M. Ott, M.A.Nelman-Gonzalez, S. Clemett, S.D. Nydam, R.J. Forsyth, R.R. Davis, B.E. Crucian, H. Quiriarte, K.L. Roland, K. Brenneman, C. Sams, C.Loscher & Cheryl A. Nickerson
npj Microgravity. 2017 Feb 28;3(1):10.doi:10.1038/s41526-017-0011-2 [Full Text] [Full Text PDF]

Effect of Rotation on Scaffold Motion and Cell Growth in Rotating Bioreactors.
Varley MC, Markaki AE, Brooks RA. Tissue Eng Part A. 2017 Jan 26. doi: 10.1089/ten.TEA.2016.0357. [Abstract]

RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment.
Louis F, Bouleftour, Rattner A, Linossier MT, Vico L, Guignandon A 
NPJ Microgravity. 2017 Jan 25;3:7. doi: 10.1038/s41526-016-0004-6. eCollection 2017. [Abstract]

Human three-dimensional endometrial epithelial cell model to study host interactions with vaginal bacteria and Neisseria gonorrhoeae.
Łaniewski P, Gomez A, Hire G, So M, Herbst-Kralovetz MM.Infect Immun. 2017 Jan 4. pii: IAI.01049-16. doi: 10.1128/IAI.01049-16.  [Abstract]

Three-dimensional simulated microgravity culture improves the proliferation and odontogenic differentiation of dental pulp stem cell in PLGA scaffolds implanted in mice.
Li Y, He L, Pan S, Zhang L, Zhang W, Yi H, Niu Y. Mol Med Rep. 2017 Feb;15(2):873-878. doi: 10.3892/mmr.2016.6042. Epub 2016 Dec 14. [Abstract]







Related Links

Malignant bone disease

Single Use 3D BioreactorsAutoclavable 3D BioreactorsStem Cell Culture SystemsPerfusion Bioreactors Nanobiomatrix ScaffoldsBiostructure Matrix Scaffolds
Synthecon, Incorporated | 8977 Interchange Dr. | Houston, Texas 77054 | (713) 741-2582 | Toll Free (800) 853-0740
Website by SinyakCreative
© 2019 Synthecon, Incorporated, All Rights Reserved