Synthecon: 3D Culture Systems for 3D World!

Research Publications / Osteo

Combined Effects of Simulated Microgravity and Radiation Exposure on Osteoclast Cell Fusion.
Shanmugarajan S, Zhang Y, Moreno-Villanueva M, Clanton R, Rohde LH, Ramesh GT, Sibonga JD, Wu H.Int J Mol Sci. 2017 Nov 18;18(11). pii: E2443. doi: 10.3390/ijms18112443. [Full Text]

Genome-wide analysis and prediction of functional long noncoding RNAs in osteoblast differentiation under simulated microgravity. Hu Z, Wang H, Wang Y, Zhou H, Shi F, Zhao J, Zhang S, Cao X.
Mol Med Rep. 2017 Dec;16(6):8180-8188. doi: 10.3892/mmr.2017.7671. [Full Text]

Three-dimensional simulated microgravity culture improves the proliferation and odontogenic differentiation of dental pulp stem cell in PLGA scaffolds implanted in mice.
Li Y, He L, Pan S, Zhang L, Zhang W, Yi H, Niu Y. Mol Med Rep. 2017 Feb;15(2):873-878. doi: 10.3892/mmr.2016.6042. Epub 2016 Dec 14. [Abstract]

RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment.
Louis F, Bouleftour, Rattner A, Linossier MT, Vico L, Guignandon A 
NPJ Microgravity. 2017 Jan 25;3:7. doi: 10.1038/s41526-016-0004-6. eCollection 2017. [Abstract]

Microgravity Induction of TRAIL Expression in Preosteoclast Cells Enhances Osteoclast Differentiation.
Sambandam Y, Baird KL, Stroebel M, Kowal E, Balasubramanian S, Reddy SV. Sci Rep. 2016 May 4;6:25143. doi: 10.1038/srep25143. [Abstract]

Establishment of a 3D-dynamic osteoblasts-osteoclasts co-culture model to simulate the jawbone microenvironment in vitro.
Penolazzi L, Lolli A, Sardelli L, Angelozzi M, Lambertini E, Trombelli L, Ciarpella F, RenataVecchiatini, Piva R. Life Sci. 2016 Mar 22. pii: S0024-3205(16)30151-5. doi: 10.1016/j.lfs.2016.03.035. [Abstract]

The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro.
Spatz JM, Wein MN, Gooi JH, Qu Y, Garr JL, Liu S, Barry KJ, Uda Y, Lai F, Dedic C, Balcells-Camps M, Kronenberg HM, Babij P, Pajevic PD. J Biol Chem. 2015 Jul 3;290(27):16744-58. doi: 10.1074/jbc.M114.628313. Epub 2015 May 7. [Abstract] [Full Text]

The Effect of OSM on MC3T3-E1 Osteoblastic Cells in Simulated Microgravity with Radiation.
Goyden Goyden J, Tawara K, Hedeen D, Willey JS, Thom Oxford J, Jorcyk CL.PLoS One. 2015 Jun 1;10(6):e0127230. doi: 10.1371/journal.pone.0127230. eCollection 2015 [Abstract] [Full Text]

A mesoscale study of the degradation of  bone structural properties in modeled microgravity conditions.
Cosmi F, Steimberg N, Mazzoleni G. J Mech Behav Biomed Mater. 2015 Jan 12;44C:61-70. doi: 10.1016/j.jmbbm.2015.01.002 [Abstract] [Full Text]

Effect of dynamic three-dimensional culture on osteogenic potential of human periodontal ligament-derived mesenchymal stem cells entrapped in alginate microbeads.
Vecchiatini R, Penolazzi L, Lambertini E, Angelozzi M, Morganti C, Mazzitelli S, Trombelli L, Nastruzzi C, Piva R. J Periodontal Res. 2014 Sep 23. doi: 10.1111/jre.12225. [Abstract]
Conditioned media from microvascular endothelial cells cultured in simulated microgravity inhibit osteoblast activity.
Cazzaniga A, Castiglioni S, Maier JA. Biomed Res Int. 2014;2014:857934. doi: 10.1155/2014/857934. [Abstract] [Full Text] [Full Text pdf]

Microgravity control of autophagy modulates osteoclastogenesis.
Sambandam Y, Townsend MT, Pierce JJ, Lipman CM1, Haque A, Bateman TA, Reddy SV; Bone. 2014 Jan 23. pii: S8756-3282(14)00006-4. doi: 10.1016/j.bone.2014.01.004. [Abstract]
Nano-ceramic composite scaffolds for bioreactor-based bone engineering. 
Lv Q, Deng M, Ulery BD, Nair LS, Laurencin CT.Clin Orthop Relat Res. 2013 Aug;471(8):2422-33. doi: 10.1007/s11999-013-2859-0. [Abstract]
In vitro three-dimensional development of mouse molar tooth germs in a rotary cell culture system.
Sun L, Yang C, Ge Y, Yu M, Chen G, Guo W, Tian W.; Int J Paediatr Dent. 2013 Jul 19. doi: 10.1111/ipd.12057. [Abstract]
The effects of simulated microgravity on intervertebral disc degeneration.
Jin L, Feng G, Reames DL, Shimer AL, Shen FH, Li X.  Spine J. 2013 Mar;13(3):235-42. doi: 10.1016/j.spinee.2012.01.022. [Abstract]
Numerical simulation of fluid field and in vitro three-dimensional fabrication of tissue-engineered bones in a rotating bioreactor and in vivo implantation for repairing segmental bone defects.
Song K, Wang H, Zhang B, Lim M, Liu Y, Liu T. Cell Stress Chaperones. 2013 Mar;18(2):193-201. doi: 10.1007/s12192-012-0370-2.[Abstract] [Full Text] [Full Text pdf]
Engineered bone tissue associated with vascularization utilizing a rotating wall vessel bioreactor.
Nishi M, Matsumoto R, Dong J, Uemura T. J Biomed Mater Res A. 2012 Aug 3. doi: 10.1002/jbm.a.34340 [Abstract]
Differentiation of human mesenchymal stem cell spheroids under microgravity conditions
Cerwinka WH, Sharp SM, Boyan BD, Zhau HE, Chung LWK, Yates C,  Cell Regeneration 2012, 1:2  [Abstract] [Full Text] [Full Text pdf]
Destrin deletion enhances the bone loss in hindlimb suspended mice.
Shuang F, Sun Y, Yang HH, Shao YC, Li H, Hu W, Zhong J, Zou HX. Eur J Appl Physiol. 2013 Feb;113(2):403-10. doi: 10.1007/s00421-012-2451-4.[Abstract in English]
The effect of Smads signal pathway on the osteogenesis of human periodontal ligament stem cells in simulated microgravity.
Li Y, Li S, Niu ZY, Bao B, Shi X.; Shanghai Kou Qiang Yi Xue. 2012 Jun;21(3):246-50.(Article in Chinese) [Abstract]
Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats. 
Sun Y, Shuang F, Chen DM, Zhou RB. Osteoporos Int. 2013 Mar;24(3):969-78. doi: 10.1007/s00198-012-2028-4. [Abstract]
Freeze-dried human serum albumin improves the adherence and proliferation of mesenchymal stem cells on mineralized human bone allografts.
Weszl M, Skaliczki G, Cselenyák A, Kiss L, Major T, Schandl K, Bognár E, Stadler G, Peterbauer A, Csönge L. J Orthop Res. 2012 Mar; 30(3):489-96. [Abstract]
Cementum protein 1 (CEMP1) induces differentiation by human periodontal ligament cells under three-dimensional culture conditions. 
Hoz L, Romo E, Zeichner-David M, Sanz M, Nuñez J, Gaitán L, Mercado G, Arzate H., Cell Biol Int. 2012 Feb 1;36(2):129-36. [Abstract]
3D sample preparation for orthopaedic tissue engineering bioreactors. 
Cartmell SH, Rathbone S, Jones G, Hidalgo-Bastida LA. (Textbook chapter in 3D Cell Culture: Methods and Protocols, ISBN 978-1-60761-983-3) [Abstract] [Publisher website for texbook]
Bioreactor systems for bone tissue engineering.
Rauh J, Milan F, Günther KP, Stiehler M. Tissue Eng Part B Rev. 2011 Aug;17(4):263-80. [Abstract]
RCCS enhances EOE cell proliferation and their differentiation into ameloblasts.
Li P, Zhang Y, Wang YM, Duan CM, Hao T, Wu BL, Wang CY. Mol Biol Rep. 2012 Jan;39(1):309-17. doi: 10.1007/s11033-011-0740-3. Epub June 2011 [Abstract]
Enhancement of matrix production and cell proliferation in human annulus cells under bioreactor culture.
Yang X, Wang D, Hao J, Gong M, Arlet V, Balian G, Shen FH, Li XJ. Tissue Eng Part A.; 17(11-12):1595-603, June 2011 [Abstract]
Bone tissue engineering bioreactors: dynamic culture and the influence of shear stress.
Yeatts AB, Fisher JP. Bone; 48(2):171-81. 2011[Abstract]
Microarray profile of gene expression during osteoclast differentiation in modelled microgravity.
Sambandam Y, Blanchard JJ, Daughtridge G, Kolb RJ, Shanmugarajan S, Pandruvada SN, Bateman TA, Redd., J Cell Biochem. 2010 Dec 1;111(5):1179-87. [Abstract]
The effect of simulated microgravity on human mesenchymal stem cells cultured in an osteogenic differentiation system: a bioinformatics study.
Sheyn D, Pelled G, Netanely D, Domany E, Gazit D. Tissue Eng Part A. 16(11):3403-12, 2010 [Abstract]
Enhanced cell ingrowth and proliferation through three dimensional nano composite scaffolds with controlled pore structures.
Lee KW, Wang S, Dadsetan M, Yaszemski MJ, Lu L.  Biomacromolecules. 11:682-9, 2010. [Abstract] [Full Text] [Full Text pdf]
Analysis of the attachment and differentiation of three-dimensional rotary wall vessel cultured human preosteoblasts on dental implant surfaces.
Ko YJ, Zaharias RS, Seabold DA, Lafoon JE, Schneider GB.  Int J Oral Maxilofac Implants 25:722-728, 2010 [Abstract]
Establishment of three-dimensional tissue- engineered bone constructs under microgravity-simulating conditions.
Jin F, Zhang Y, Xuan K, He D, Deng T, Tang L, Lu W, Duan Y.  Artif Organs 34: 118-125, 2009 [Abstract]
NASA approved rotary bioreactor enhances proliferation and osteogenesis of human periodontal ligament stem cells.
Li S, a Z, Niu Z, Qian H, Xuan D, Hou R, Ni L.  Stem Cells Dev. 18:1273-82, 2009 [Abstract]
Global transcriptome analysis in mouse calvarial osteoblasts highlights sets of genes regulated by modeled microgravity and identifies a "mechanoresponsive osteoblast gene signature.
Capulli M, Rufo A, Teti A, Rucci N.  J. Cell Biochem. 107:240-52, 2009 [Abstract]
Fabrication, characterization, and in vitro evaluation of poly(lactic acid glycolic acid)/nano-hydroxyapatite composite microsphere-based scaffolds for bone tissue engineering in rotating bioreactors.
Lv Q, Nair L, Laurencin CT. J Biomed Mater Res A 91:679-691, 2009 [Abstract]
Cell-Nanofiber based cartilage tissue engineering using improved cell seeding, growth factor and bioreactor technologies.
Li WJ, Jiang, YJ, Tuan RS.  Tissue Engineering: Part A. 14: 639-48, 2008 [Abstract]
Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds and bioreactors.
August A, Marolt D, Freed LE, Vepari C, Meinel L, Farley M, Fajardo R, Patel M, Gray M, Kaplan DL, Vunjak-Novakovic G J R Soc Interface. 2008 Aug 6;5(25):929-39. doi: 10.1098/rsif.2007.1302 [Abstract[Full Text]
Osteoblast and Osteoclast Differentiation in Modeled Microgravity.
Saxena R, McDonald J. Ann NY Acad Sci. 1116: 494-498, 2007 [Abstract]
Three-dimensional expansion: in suspension culture of SD rat’s osteoblasts in a rotating wall vessel bioreactor.
Song KD, Liu TQ, Li XQ, Cui ZF, Sun XY, Ma XH.  Biomed Environ Sci 20: 91-98, 2007 [Abstract]
Repair of large osteochondral defects with allogenic cartilaginous aggregates formed from bone marrow-derived cells using RWV bioreactor.
Yoshioka T, Mishima H, Ohyabu Y, Sakai S, Akaogi H, Ishii T, Kojima H, Tanaka J, Ochiai N, Uemura T.  J Orthop Res 25:1291-1298, 2007 [Abstract]
The effect of simulated microgravity on osteoblasts is independent of the induction of apoptosis.
Bucaro MA, Zahm AM, Risbud MV, Avyaswamy PS, Mukundakrishnan K, Steinbeck MJ, Shapiro IM, Adams CS. J Cell Biochem 102: 483-495, 2007 [Abstract]
Encapsulation and osteoinduction of human periodontal ligament fibroblasts in chitosan-hydroxyapatite microspheres
Inac B, Eser Elcin A, Koc A, Balos K, Parlar A, Murat Elcin Y.  Biomed Mater Res A 82: 917-926, 2007 [Abstract]
Could the effect of modeled microgravity on osteogenic differentiation of human mesenchymal stem cells be reversed by regulation of signaling pathways?
Zheng Q, Huang G, Xu Y, Guo C, Xi Y, Pan Z, Wang J. Biol Chem 388: 755-763, 2007 [Abstract]
An ex vivo model for chondrogenesis and osteogenesis.
Pound JC, Green DW, Roach HI, Mann S, Oreffo RO.  Biomaterials 28:2839-2849, 2007 [Abstract]
Strategies to Promote Chondrogenesis and Osteogenesis from Human Bone Marrow Cells and Articular Chrondrocytes Encapsulated in Polysaccharide Templates.
Pound JC, Green DW, Chaudhuri JB, Mann S, Roach HI, Oreffo RO. Tissue Eng 12:2789-2799, 2006 [Abstract]
Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANK/OPG ratio.
Rucci N, Rufo A, Alamanou M, Teti A. J. Cell. Biochem. 100: 464-473, 2007 [Abstract]
Fabrication and detection of tissue-engineered bones with bio-derived scaffolds in a rotating bioreactor.
Song K, Yang Z, Liu T, Zhi W, Li X, Deng L, Cui Z, Ma X.  Biotechnol. Appl. Biochem. 45(pt 2): 65-74, 2006 [Abstract]
Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors.
Marolt D, Augst A, Freed LE, Vepari C, Fajardo R, Patel N, Gray M, Farley M, Kaplan D, Vunjak-Novakovic G.  Biomaterials 27: 6138-6149, 2006 [Abstract]
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