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Research Publications / Spaceflight Physiology

Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis.
Wang S, Yin Z, Zhao B, Qi Y, Liu J, Rahimi SA, Lee LY, Li S. 
Stem Cell Res. 2017 Dec;25:157-165. doi: 10.1016/j.scr.2017.11.002. Epub 2017 Nov 7. [Abstract]

Combined Effects of Simulated Microgravity and Radiation Exposure on Osteoclast Cell Fusion.
Shanmugarajan S, Zhang Y, Moreno-Villanueva M, Clanton R, Rohde LH, Ramesh GT, Sibonga JD, Wu H.Int J Mol Sci. 2017 Nov 18;18(11). pii: E2443. doi: 10.3390/ijms18112443. [Full Text]

T cell resistance to activation by dendritic cells requires long-term culture in simulated microgravity.
Bradley JH, Stein R, Randolph B, Molina E, Arnold JP, Gregg RK. Life Sci Space Res (Amst). 2017 Nov;15:55-61. doi: 10.1016/j.lssr.2017.08.002. Epub 2017 Aug 8. [Abstract]

Genome-wide analysis and prediction of functional long noncoding RNAs in osteoblast differentiation under simulated microgravity. Hu Z, Wang H, Wang Y, Zhou H, Shi F, Zhao J, Zhang S, Cao X.
Mol Med Rep. 2017 Dec;16(6):8180-8188. doi: 10.3892/mmr.2017.7671. [Full Text]

Simulated microgravity impairs cardiac autonomic neurogenesis from neural crest cells.
Hatzistergos KE, Jiang Z, Valasaki K, Takeuchi LM, Balkan W, Atluri P, Saur D, Seidler B, Tsinoremas N, DiFede D, Hare JM.Stem Cells Dev. 2018 Jan 16. doi: 10.1089/scd.2017.0265. [Abstract]

Regulation of the Response of Caenorhabditis elegans to Simulated Microgravity by p38 Mitogen-Activated Protein Kinase Signaling.
Li W, Wang D, Wang D. Sci Rep. 2018 Jan 16;8(1):857. doi: 10.1038/s41598-018-19377-z. [Full Text]

Effect Of Microgravity On Aromatase Expression In Sertoli Cells.
Cirelli E1, De Domenico E, Botti F, Massoud R, Geremia R, Grimaldi P. Sci Rep. 2017 Jun 14;7(1):3469. doi: 10.1038/s41598-017-02018-2. [Abstract]

Effect of microgravity on the mesenchymal stem cell characteristics of limbal fibroblasts.
Pao SI, Chien KH, Lin HT, Tai MC, Chen JT, Liang CM. J Chin Med Assoc. 2017 May 18. pii: S1726-4901(17)30109-0. doi: 10.1016/j.jcma.2017.01.008. [Abstract] [Full Text]

RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment.
Louis F, Bouleftour, Rattner A, Linossier MT, Vico L, Guignandon A 
NPJ Microgravity. 2017 Jan 25;3:7. doi: 10.1038/s41526-016-0004-6. eCollection 2017. [Abstract]

Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection.
Feger BJ, Thompson JW, Dubois LG, Kommaddi RP, Foster MW, Mishra R, Shenoy SK, Shibata Y, Kidane YH, Moseley MA, Carnell LS, Bowles DE. Sci Rep. 2016 Sep 27;6:34091. doi: 10.1038/srep34091. [Abstract] [Full Text]

Microgravity as a biological tool to examine host-pathogen interactions and to guide development of therapeutics and preventatives that target pathogenic bacteria.
Higginson EE1, Galen JE1, Levine MM2, Tennant SM3. Pathog Dis. 2016 Sep 13. pii: ftw095. [Abstract] [Full Text]

Transfection of the IHH gene into rabbit BMSCs in a simulated microgravity environment promotes chondrogenic differentiation and inhibits cartilage aging. 
Liu PC, Liu K1, Liu JF, Xia K, Chen LY, Wu X. Oncotarget. 2016 Sep 6;7(39):62873-62885. doi: 10.18632/oncotarget.11871. [Abstract] [FullText]

The Role of Parathyroid Hormone-Related Protein (PTHrP) in Osteoblast Response to Microgravity: Mechanistic Implications for Osteoporosis Development.
Camirand A, Goltzman D, Gupta A, Kaouass M, Panda D, Karaplis A. PLoS One. 2016 Jul 27;11(7):e0160034. doi: 10.1371/journal.pone.0160034. eCollection 2016.  [Full Text]

Simulated Microgravity Disrupts Cytoskeleton Organization and Increases Apoptosis of Rat Neural Crest Stem Cells Via Upregulating CXCR4 Expression and RhoA-ROCK1-p38 MAPK-p53 Signaling.
Lin SC, Gou GH, Hsia CW, Ho CW, Huang KL, Wu YF, Lee SY, Chen YH. Stem Cells Dev. 2016 Jul 6. [Abstract]

Effects of simulated microgravity on human brain nervous tissue.
Wang X, Du J, Wang D, Zeng F, Wei Y, Wang F, Feng C, Li N, Dai R, Deng Y, Quan Z, Qing H.
Neurosci Lett. 2016 Aug 3;627:199-204. doi: 10.1016/j.neulet.2016.06.004. Epub 2016 Jun 3. [Abstract]

The International Space Station: an Extreme Environment for Key Host-Microbe Discoveries
C. Mark Ott, Thomas Marshburn, and Cheryl A. Nickerson. Microbe—Volume 11, Number 6, 2016, Pages 253-261. [Abstract]

Increased biofilm formation ability in Klebsiella pneumoniae after short-term exposure to a simulated microgravity environment.
Wang H, Yan Y, Rong D, Wang J, Wang H, Liu Z, Wang J, Yang R, Han Y. Microbiologyopen. 2016 May 16. doi: 10.1002/mbo3.370. [Abstract]

Microgravity Induction of TRAIL Expression in Preosteoclast Cells Enhances Osteoclast Differentiation.
Sambandam Y, Baird KL, Stroebel M, Kowal E, Balasubramanian S, Reddy SV. Sci Rep. 2016 May 4;6:25143. doi: 10.1038/srep25143. [Abstract]

Simulated Microgravity Using a Rotary Culture System Compromises the In Vitro Development of Mouse Preantral Follicles.
Zhang S, Zheng D, Wu Y, Lin W, Chen Z, Meng L, Liu J, Zhou Y1,.PLoS One. 2016 Mar 10;11(3):e0151062. doi: 10.1371/journal.pone.0151062. eCollection 2016. [Abstract] [Full Text]

Influence of Low-Shear Modeled Microgravity on Heat Resistance, Membrane Fatty Acid Composition, and Heat Stress-Related Gene Expression in Escherichia coli O157:H7 ATCC 35150, 43889, 43890, and 43895.
Kim HW, Rhee MS. Appl Environ Microbiol. 2016 Mar 4. pii: AEM.00050-16.Appl Environ Microbiol. 2016 Mar 4. pii: AEM.00050-16. [Abstract] 

A Study of Alterations in DNA Epigenetic Modifications (5mC and 5hmC) and Gene Expression Influenced by Simulated Microgravity in Human Lymphoblastoid Cells.
Chowdhury B, Seetharam A, Wang Z, Liu Y, Lossie AC, Thimmapuram J, Irudayaraj J. PLoS One. 2016 Jan 28;11(1):e0147514. doi: 10.1371/journal.pone.0147514. eCollection 2016. [Abstract] [Full Text]


Hetero-cellular prototyping by synchronized multi-material bioprinting for rotary cell culture system.
Snyder J1, Son AR, Hamid Q, Wu H, Sun W. Biofabrication. 2016 Jan 13;8(1):015002. [Abstract]

High throughput de novo RNA sequencing elucidates novel responses in Penicillium chrysogenum under microgravity.
Sathishkumar Y, Krishnaraj C, Rajagopal K, Sen D,, Lee YS.Bioprocess Biosyst Eng. 2015 Nov 24. [Abstract]

Adrenomedullin is a key Protein Mediating Rotary Cell Culture System that Induces the Effects of Simulated Microgravity on Human Breast Cancer Cells
Li Chen, Xi Yang, Xiang Cui, Minmin Jiang, Yu Gui, Yanni Zhang, Xiangdong Luo Microgravity Science and Technology November 2015, Volume 27, Issue 6, pp 417-426 [Abstract]

Effect of Culture in Simulated Microgravity on the Development of Mouse Embryonic Testes.
Nowacki D, Klinger FG, Mazur G, Felici MD. Adv Clin Exp Med. 2015 Sep-Oct;24(5):769-74. doi: 10.17219/acem/27920. [Abstract] [Full Text]

Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene Networks
Prasanna Vidyasekar, Pavithra Shyamsunder, Rajpranap Arun, Rajalakshmi Santhakumar, Nand Kishore Kapadia, Ravi Kumar, and Rama Shanker Verma PLoS One. 2015; 10(8): e0135958. Published online 2015 Aug 21.  doi:  10.1371/journal.pone.0135958 [Abstract] [Full Text]

The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro.
Spatz JM, Wein MN, Gooi JH, Qu Y, Garr JL, Liu S, Barry KJ, Uda Y, Lai F, Dedic C, Balcells-Camps M, Kronenberg HM, Babij P, Pajevic PD. J Biol Chem. 2015 Jul 3;290(27):16744-58. doi: 10.1074/jbc.M114.628313. Epub 2015 May 7. [Abstract] [Full Text]

The Effect of OSM on MC3T3-E1 Osteoblastic Cells in Simulated Microgravity with Radiation.
Goyden Goyden J, Tawara K, Hedeen D, Willey JS, Thom Oxford J, Jorcyk CL.PLoS One. 2015 Jun 1;10(6):e0127230. doi: 10.1371/journal.pone.0127230. eCollection 2015 [Abstract] [Full Text]

A mesoscale study of the degradation of bone structural properties in modeled microgravity conditions.
Cosmi F, Steimberg N, Mazzoleni G. J Mech Behav Biomed Mater. 2015 Jan 12;44C:61-70. doi: 10.1016/j.jmbbm.2015.01.002 [Abstract] [Full Text]
 
Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early t-cell activation. 
Martinez EM, Yoshida MC, Candelario TT, Hughes-Fulford M. Am J Physiol Regul Integr Comp Physiol. 2015 Jan 7:ajpregu.00449.2014. doi:10.1152/ajpregu.00449.2014. [Epub ahead of print] [Abstract]
 
The impact of simulated and real microgravity on bone cells and mesenchymal stem cells
Ulbrich C, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, Magnusson N, Infanger M, Grosse J, Eilles C, Sundaresan A, Grimm D. Biomed Res Int. 2014;2014:928507. doi: 10.1155/2014/928507.[Abstract] [Full Text] [Full Text pdf]
 
Experimental study on effect of simulated microgravity on structural chromosome instability of human peripheral blood lymphocytes.
Wei L, Liu C, Kang L, Liu Y, Shi S, Wu Q, Li Y.  PLoS One. 2014 Jun 25;9(6):e100595. doi: 10.1371/journal.pone.0100595. eCollection 2014. [Abstract] [Full Text] [Full Text pdf]

Integration Analysis of MicroRNA and mRNA Expression Profiles in Human Peripheral Blood Lymphocytes Cultured in Modeled Microgravity.
Girardi C, De Pittà C, Casara S, Calura E, Romualdi C, Celotti L, Mognato M. Biomed Res Int. 2014;2014:296747. doi: 10.1155/2014/296747 [Abstract] [Full Text] [Full Text pdf]
 
Conservation of the Low-shear Modeled Microgravity Response in Enterobacteriaceae and Analysis of the trp Genes in this Response.
Soni A, O'Sullivan L, Quick LN, Ott C, Nickerson CA, Wilson JW.Open Microbiol J. 2014 Jun 13;8:51-8. doi: 10.2174/1874285801408010051. [Abstract] [Full Text] [Full Text pdf]
 
Growing tissues in real and simulated microgravity - new methods for tissue engineering.
Grimm D, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, Ulbrich C, Magnusson NE, Infanger M, Bauer J.; Tissue Eng Part B Rev. 2014 Apr 4. [Epub ahead of print] [Abstract]
 
Microgravity control of autophagy modulates osteoclastogenesis.
Sambandam Y, Townsend MT, Pierce JJ, Lipman CM1, Haque A, Bateman TA, Reddy SV; Bone. 2014 Jan 23. pii: S8756-3282(14)00006-4. doi: 10.1016/j.bone.2014.01.004. [Abstract]
 
Simulated microgravity increases heavy ion radiation-induced apoptosis in human B lymphoblasts.
Dang B, Yang Y, Zhang E, Li W, Mi X, Meng Y, Yan S, Wang Z, Wei W, Shao C, Xing R, Lin C; Life Sci. 2013 Dec 21. pii: S0024-3205(13)00755-8. doi:10.1016/j.lfs.2013.12.008  [Abstract]
 
Impact of simulated microgravity on the normal developmental time line of an animal-bacteria symbiosis.
Foster JS, Khodadad CL, Ahrendt SR, Parrish ML Sci Rep. 2013 Feb 26;3:1340. doi: 10.1038/srep01340. [Abstract] [Full Text] [Full Text pdf]
 
Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats.
Sun Y, Shuang F, Chen DM, Zhou RB. Osteoporos Int. 2013 Mar;24(3):969-78. doi: 10.1007/s00198-012-2028-4. [Abstract]
 
Expression of Multiple Stress Response Genes by Escherichia Coli Under Modeled Reduced Gravity.
Vukanti R, Leff LG. J Microgravity Science and Technology. 2012 Sept 1;24(4):267-79. doi: 10.1007/s12217-012-9310-0. [Abstract]
 
The effects of simulated microgravity on intervertebral disc degeneration.
Jin L, Feng G, Reames DL, Shimer AL, Shen FH, Li X.  Spine J. 2013 Mar;13(3):235-42. doi: 10.1016/j.spinee.2012.01.022. [Abstract]
 
Destrin deletion enhances the bone loss in hindlimb suspended mice.
Shuang F, Sun Y, Yang HH, Shao YC, Li H, Hu W, Zhong J, Zou HX. Eur J Appl Physiol. 2013 Feb;113(2):403-10. doi: 10.1007/s00421-012-2451-4.[Abstract in English]
 
Analysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiationresponse of human lymphocytes under modeled microgravity.
Girardi C, De Pittà C, Casara S, Sales G, Lanfranchi G, Celotti L, Mognato M. PLoS One. 2012; 7(2):e31293.[Abstract] [Full Text] [Full Text pdf]
 
Rotating wall vessel exposure alters protein secretion and global gene expression in Staphylococcus aureus.
Rosado H, O’Neill AJ, Blake KL, Walther M, Long PF, Hinds J, Taylor PW. International Journal of Astrobiology. 2012 Apr;11(2):71-81. doi: 10.1017/S1473550411000346. [Abstract]
 
Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen.
Crabbé A, Schurr MJ, Monsieurs P, Morici L, Schurr J, Wilson JW, Ott CM, Tsaprailis G, Pierson DL, Stefanyshyn-Piper H, Nickerson CA. Appl Environ Microbiol. 2011 Feb;77(4):1221-30. [Abstract] [Full Text] [Full Text pdf]
 
Spaceflight and modeled microgravity effects on microbial growth and virulence.
Rosenzweig JA, Abogunde O, Thomas K, Lawal A, Nguyen YU, Sodipe A, Jejelowo O. Appl Microbiol Biotechnol 85:885-891, 2010 [Abstract] [Full Text] [Full Text pdf]
 
Response of Pseudomonas aeruginosa PAO1 to low shear modeled microgravity involves AlgU regulation.
Crabbe A, Pycke B, Van Houdt R, Monsieurs P, Nickerson C, Leys N, Cornelis P. Environ Microbiol 12:1545- 1564, 2010 [Abstract]
Microarray profile of gene expression during osteoclast differentiation in modelled microgravity.
Sambandam Y, Blanchard JJ, Daughtridge G, Kolb RJ, Shanmugarajan S, Pandruvada SN, Bateman TA, Redd., J Cell Biochem. 2010 Dec 1;111(5):1179-87. [Abstract]
 
Differential translocation of nuclear factor-kappaB in a cardiac muscle cell line under gravitational changes.
Kwon O, Tranter M, Jones WK, Sankiovic JM, Banerjee RK. J Biomech Eng. 131:064503, 2009 [Abstract]
 
Bacillus thuringiensis conjugation in simulated microgravity.
Beuls E, Van Houdt R, Leys Y, Dijkstra C Larkin O, Mahillon J. Astrobiology. 9: 797-805, 2009 [Abstract]

A major effect of simulated microgravity on several stages of preimplantation mouse development is lethality associated with elevated phosphorylated SAPK/JNK.
Wang Y1, Xie Y, Wygle D, Shen HH, Puscheck EE, Rappolee DA.
Reprod Sci. 2009 Oct;16(10):947-59. doi: 10.1177/1933719109337544. Epub 2009 Jun 22. [Full Text]
 
Sub-mitogenic phorbol myristate acetate co-stimulation rescues the PHA-induced activation of both naïve and memory T cells cultured in the rotating-wall vessel bioreactor.
Simmons DM, Gardner EM, Lelkes PI. Cell Biol Intl. 33:882-6, 2009 [Abstract]
 
Global transcriptome analysis in mouse calvarial osteoblasts highlights sets of genes regulated by modeled microgravity and identifies a "mechanoresponsive osteoblast gene signature"
Capulli M, Rufo A, Teti A, Rucci N.  J. Cell Biochem. 107:240-52, 2009 [Abstract]

 
Simulated microgravity decreases DNA repair capacity and induces DNA damage in human lymphocytes.
Kumari R, Singh KP, Dumond JW Jr. J. Cell Biochem.107:723-31, 2009 [Abstract]

Media Ion Composition Controls Regulatory and Virulence Response of Salmonella in Spaceflight. 
Wilson JW ,Ott CM, Quick L, Davis R, Zu Bentrup KH, Crabbe´ A, Richter E, Sarker S, Barrila J, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Shah M, Nelman-Gonzalez M, Hing S, Parra M, Dumars P, Norwood K, Bober R, Devich J, Ruggles A, deBaca AC, Narayan S, Benjamin J, Goulart C, Rupert M, Catella L, Schurr MJ, Buchanan K, Morici L, McCracken J, Porter MD, Pierson DL, Smith SM, Mergeay M, Leys N, Stefanyshyn-Piper HM, Gorie D, Nickerson CA. PLos ONE 3: e3923, 2008 [Abstract] [Full Text] [Full Text pdf]
 
Osteoblast and Osteoclast Differentiation in Modeled Microgravity.
Saxena R, McDonald J. Ann NY Acad Sci. 1116: 494-498, 2007 [Abstract]
 
The effect of simulated microgravity on osteoblasts is independent of the induction of apoptosis.
Bucaro MA, Zahm AM, Risbud MV, Avyaswamy PS, Mukundakrishnan K, Steinbeck MJ, Shapiro IM, Adams CS. J Cell Biochem 102: 483-495, 2007 [Abstract]
 
Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANK/OPG ratio.
Rucci N, Rufo A, Alamanou M, Teti A. J. Cell. Biochem. 100: 464-473, 2007 [Abstract]
A Potential Cause for Kidney Stone Formation During Space Flights: Enhanced Growth of Nanobacteria in Microgravity.
Ciftcioglu N, Haddad RS, Golden DC, Morrison DR, McKay DS: Kidney Int. 67: 483- 491, 2005. [Abstract]
 
Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq.
Wilson JW, Ott CM, Zu Bentrup KH, Ramamurthy R, Quick L, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Fernandez D, Richter E, Shah WM, Kilcoyne M, Joshi L, Nelman-Gonzalez M, Hing S, Parra M, Dumars P, Norwood K, Bober R, Devich J, Ruggles A, Goulart C, Rupert M, Stodieck L, Stafford P, Catella L, Schurr MJ, Buchanan K, Morici L, McCracken J, Allen P, Baker-Colman C, Hammond T, Vogel J, Nelson R, Pierson DL, Stefanyshyn-Piper HM, Nickerson CA. Proc Natl Acad Sci USA 104: 16299-16304, 2007[Abstract] [Full Text] [Full Text pdf]
 
Gene expression alterations in activated human T-cells induced by modeled microgravity.
Ward NE, Pellis NR, Risin SA, Risin D.; J. Cell. Biochem. 99: 1187-1202, 2006 [Abstract]
 
Impact of modeled microgravity on microvascular endothelial cells.Cotrupi S, Ranzani D, Maier JA: Biochem Biophys Acta 1746(2):163-168, 2005. [Abstract in English, Article in Chinese]
Impact of Modeled Microgravity on Migration, Differentiation, and Cell Cycle Control of Primitive Human Hematopoietic Progenitor Cells.
Plett PA, Abonour R, Frankovitz SM, Orschell CM; Experimental Hematology 32: 773-781, 2004. [Abstract]
Low-Shear Modeled Microgravity: A Global Environmental Regulatory Signal Affecting Bacterial Gene Expression
Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, LeBlanc CL,et al.: Physiology, and Pathogenesis. Journal of Microbiological Methods 54:1-11, 2003. [Abstract]
 
Effect of Simulated Microgravity on the Production of IL-12 by PBMC’s.
Bakos A, Varkonyi A, Minarovits J, Batkai L:  J Gravit Physiol. 9: 293-294, 2002. [Abstract]
Low-Shear Modeled Microgravity Alters the Salmonella Enterica Serovar Typhimurium Stress Response in an RpoSindependent Manner.
Wilson JW, Ott CM, Ramamurthy R, Porwollik S, McClelland M, Pierson DL, Nickerson CA. Applied and Environmental Microbiology 68:5408-5416, 2002. [Abstract] [Full Text] [Full Text pdf]
Microarray Analysis Identifies Salmonella Genes Belonging to the Low-Shear Modeled Microgravity Regulon
Wilson JW, Ramamurthy R, Porwollik S, McClelland M, Hammond T, Allen P, Ott CM, Pierson DL, Nickerson CA:  Proc. Natl. Acad. Sci. USA 99: 13807-13812, 2002  [Abstract] [Full Text] [Full Text pdf]
 
Proliferation of Human Hematopoietic Bone Marrow Cells in Simulated Microgravity.
Plett PA, Frankovitz SM, Abonour R, Orschell-Traycoff CM; In Vitro Cell Dev Biol Anim 37: 73-78, 2001. [Abstract]
Simulated Microgravity Impairs Respiratory Burst Activity in Human Promyelocytic Cells.
Hughes JH and Long JP; In Vitro Cell Dev Biol Anim 37: 209-215, 2001. [Abstract]
 
Secondary Metabolism in Simulated Microgravity
Demain AL and Fang A: Chem Rec 1: 333-346, 2001. [Abstract]
 
Multiple Interleukin-2 Signaling Pathways Differentially Regulated by Microgravity.
Licato LL, Grimm EA; Immunopharmacology 44: 273-9, 1999. [Abstract]
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