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Research Publications / General Articles
3D sample preparation for orthopaedic tissue engineering bioreactors | Cartmell SH, Rathbone S, Jones G, Hidalgo-Bastida LA | Textbook chapter in 3D Cell Culture: Methods and Protocols, ISBN 978-1-60761-983-3 |
A Countermeasure to Ameliorate Immune Dysfunction in In Vitro Simulated Microgravity Environment: Role of Cellular Nucleotide Nutrition | Hales NW, Yamauchi K, Martinez AA, Sundaresan A, Pellis NR and Kulkarni AD | In Vitro Cell Dev Biol (Animal) 38(4):213-217, 2002 |
A Critical Period for Functional Vestibular Development in Zebrafish | Moorman SJ, Cordova R, Davies SA | Dev Dyn 223: 285-291, 2002 |
Advances in Cellular Construction. | Spaulding GF, Jessup JM and Goodwin TJ | J Cell Biochem 51: 249-251, 1993 [PubMed ID: 8501125] |
Analysis of Gravity-Induced Particle Motion and Fluid Perfusion Flow in the NASADesigned Rotating Zero-Head-Space Tissue Culture Vessel. | Wolf DA, Schwarz RP | NASA Technical Paper 3143, October, 1991. |
Artificial tissue creation under microgravity conditions: Considerations and future applications | Swaminathan V, Bechtel G, V Tchantchaleishvili V | Artif Organs (2021) 45(12):1446-1455 |
Assessing cisplatin-induced ototoxicity and otoprotection in whole organ culture of the mouse inner ear in simulated microgravity | Tropitzsch A, Arnold H, Bassiouni M, Müller A, Eckhard A, Müller M, Löwenheim H. | Toxicol Lett. 2014 Apr 5. pii: S0378-4274(14)00144-1. doi: 10.1016/j.toxlet.2014.03.022. |
Bioreactor systems for bone tissue engineering | Rauh J, Milan F, Günther KP, Stiehler M | Tissue Eng Part B Rev. 2011 Aug;17(4):263-80 |
Cell Culture for Three-Dimensional Modeling in Rotating Wall Vessels: An Application of Simulated Microgravity | Schwarz RP, Goodwin TJ, Wolf DA | J Tissue Culture Methods 14: 51-58, 1992 |
Changes in gravitational force affect gene expression in developing organ systems at different developmental times. | Shimada N, Sokunbi G, Moorman SJ | BMC Dev Biol 5: 10 , 2005 |
Comparative Effectiveness of a Clinostat and a Slow-Turning Lateral Vessel at Mimicking the Ultrastructural Effects of Microgravity in Plant Cells | Moore R. | Ann Bot (Lond). 66: 541-549, 1990 |
Continuous Glucose Monitoring and Control in a Rotating Wall Perfused Bioreactor. | Xu Y, Sun J, Mathew G, Jeevarajan AS, Anderson MM | Biotechnol Bioeng. 86: 473-477, 2004 |
Continuous pH Monitoring in a Perfused Bioreactor System Using an Optical pH Sensor. | Jeevarajan AS, Vani S, Taylor TD, Anderson MM | Biotechnol Bioeng 78: 467-472, 2002 |
Cultivation of Lacrimal gland acinar cells in a microgravity environment. | Schrader S, Kremling C, Clinger M, Lagua H, Geerling G | Br J Ophthalmol. 93: 1121-1125, 2009 |
Culturing and applications of rotating wall vessel bioreactor derived 3D epithelial cell models. (Video Article) | Radtke AL, Herbst-Kralovetz MM | J Vis Exp. 2012 Apr 3;(62). pii: 3868. doi: 10.3791/3868 |
Does reduced gravity alter cellular responses to ionizing radiation? | Manti L. | Radiat Environ Biophys 45: 1-8, 2006 |
Effect of Microgravity on Fungistatic Activity of an α-Aminophosphonate Chitosan Derivative against Aspergillus niger | Kesavan Devarayan , Yesupatham Sathishkumar , Yang Soo Lee , Byoung-Suhk Kim | Published: October 15, 2015http://dx.doi.org/10.1371/journal.pone.0139303 |
Effect of Rotation on Scaffold Motion and Cell Growth in Rotating Bioreactors | Varley MC, Markaki AE, Brooks RA | Tissue Eng Part A. 2017 Jan 26. doi: 10.1089/ten.TEA.2016.0357 |
Effect of simulated microgravity on metabolism of HGC‑27 gastric cancer cells | ZHENG‑YANG CHEN1, NAN JIANG1,2, S Guo, B‑B Li, J‑Q Yang,S‑B Chai, H‑F Yan, P‑M Sun, T Zhang, H‑W Sun, H‑M Yang, J‑L Zhou and Y Cui | ONCOLOGY LETT 19: 3439-3450, 2020 |
Effects of Simulated Microgravity on Expression Profile of MicroRNA in Human Lymphoblastoid Cells | Mangala LS, Zhang Y, He Z, Emami K, Ramesh GT, Story M, Rohde LH, Wu H. | J Biol Chem. 286(37):32483-90, 2011 |
Effects of Simulated Microgravity on the Physiology of Stenotrophomonas maltophilia and Multiomic Analysis | Su X, Guo Y, Fang T, Jiang X, Wang D, Li D, Bai P, Zhang B, Wang J and Liu C | Front Microbiol 2021; 12:701265 |
Ex-Vivo Dynamic 3-D Culture of Human Tissues in the RCCS™ Bioreactor Allows the Study of Multiple Myeloma Biology and Response to Therapy. | Ferrarini M, Steimberg N, Ponzoni M, Belloni D, Berenzi A, Girlanda S, Caligaris-Cappio F, Mazzoleni G, Ferrero E. | PLoS One. 2013 Aug 26;8(8):e71613. doi: 10.1371/journal.pone.0071613. |
Exosomes derived from umbilical cord mesenchymal stem cells in mechanical environment show improved osteochondral activity via upregulation of LncRNA H19 | Yan L, Liu G, and Wu X | J Orthop Translat 26, 2021; 111–120 |
From Single Cells to Engineered and Explanted Tissues: New Perspectives in Bacterial Infection Biology | Bergmann S, Steinert M | Int Rev Cell Mol Biol. 2015;319:1-44. doi: 10.1016/bs.ircmb.2015.06.003. Epub 2015 Jul 21. |
Gene expression and survival changes in Saccharomyces cerevisiae during suspension culture. | Johanson K, Allen PL, Gonzalez-Villalobos RA, Baker CB, D'Elia R, Hammond TG | Biotechnol Bioeng 93: 1050-1059, 2006 |
Growing Tissues in Microgravity | Unsworth BR and Lelkes PI | Nature Medicine 4: 901-907, 1998 |
Growing tissues in real and simulated microgravity - new methods for tissue engineering | Grimm D, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, Ulbrich C, Magnusson NE, Infanger M, Bauer J | Tissue Eng Part B Rev. 2014 Apr 4 |
Growth and Metabolism of the Green Alga, Chlorella Pyrenoidosa, in Simulated Microgravity | Mills W.R. Pierson D.L | NASA Technical Report; 2000, NASA/JSC Life Sciences Research Laboratories Final Report |
Growth of Staphylococcus aureus Using a Rotary Cell Culture System | Hauserman MR, Rice KC | Methods Mol Biol 2021;2341:79-88. |
Human immune system adaptations to simulated microgravity revealed by single‑cell mass cytometry | Spatz JM, Hughes Fulford M, Tsai A, Gaudilliere D, Hedou J, Ganio E, Angst M, Aghaeepour N and Gaudilliere B | Scientific Reports 2021; 11:11872 |
In situ monitoring of 3D in vitro cell aggregation using an optical imaging system | Sawyer N, Worrall L, Crowe J, Waters, S, Shakesheff K, Rose F, Morgan S. | Biotechnol Bioeng 100:159-167, 2007 |
Increase in Synthesis of Human Monoclonal Antibodies by Transfected Sp2/0 Myeloma Mouse Cell Line Under Conditions of Microgravity. | Foster LJ, Catzel D, Atwa S, Zarka M, Mahler SM: | Biotechnol Lett. Aug. 25: 1271-1274, 2003 |
Inflammation is involved in response of gastric mucosal epithelial cells under simulated microgravity by integrated transcriptomic analysis. | Chai S, Guo S, Yang J, Lu S, Yuan Y, Li H, Sun P, Zhang T, Xu B, Sun H, Si S, Zhou J, Yang J, Yang H, Li Z, Cui Y | Am J Transl Res 2021;13(8):9195-9207 |
Long-Term Continuous Monitoring of Dissolved Oxygen in Cell Culture Medium for Perfused Bioreactors Using Optical Oxygen Sensors | Gao FG, Jeevarajan AS, Anderson MM | Biotechnol Bioeng. 86: 425-433, 2004 |
Low-Shear Modeled Microgravity: A Global Environmental Regulatory Signal Affecting Bacterial Gene Expression, Physiology, and Pathogenesis | Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, LeBlanc CL,et al | Journal of Microbiol Methods 54:1-11, 2003 |
Membrane Potential Mediates H+-ATPase Dependence of “Degradative Pathway” Endosomal Fusion. | Hammond T, Gonda F, Navar G, Campbell W, Majewski R, Galvan D, Pontillion F, Kaysen J, Goodwin T, Paddock S and Verroust P | J Memb Biol 162: 157-167, 1998 |
Methods for studying MLO-Y4 osteocytes in collagen-hydroxyapatite scaffolds in the rotary cell culture system | Fournier R, Harrison, RE | Connect Tissue Res . 2020; 21;1-18. |
Mitophagy contributes to endothelial adaptation to simulated microgravity | Locatelli L, Cazzaniga A, De Palma C, Castiglioni S, Maier JAM | FASEB J 2020; 34(1): 1833-1845 |
Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age | Barrila J, Crabbé A, Yang J, Franco K, Nydam SD, Forsyth RJ, Davis RR, Gangaraju S, Ott M, Coyne, CB, Bissell MJ, Nickerson CA | Infection and Immunity 2018; 86(11): e00282-18 |
Modulation of Human Endothelial Cell Behavior in Simulated Microgravity. | Carrlsson SI, Bertilaccio MT, Ascari I, Bradamante S, Maier JA | J Gravit Physiol 9: P273-274, 2002 |
Monitoring and Controlling the Dissolved Oxygen (DO) Concentration Within the High Aspect Ration Vessel (HARV) | Saarinen MA, Reece JS, Arnold MA, Murhammer DW | Biotechnol. Prog. 19; 1335-1341, 2003 |
Morin Sulphates/Glucuronides Enhance Macrophage Function in Microgravity Culture System | Hsieh C, Chao P, Fang S | European Journal of Clinical Investigation 35, 591-596, 2005 |
Morphological characteristics and proliferation of keratocytes cultured under simulated microgravity. | Chen J, Chen R, Gao S. | Artif Organs 31: 722-731, 2007 |
NASA Biotechnology: Cell Science in Microgravity | Jessup JM, and Pellis NR | In Vitro Cell Dev Biol Anim 37: 2 p preceding 63, 2001 |
Nitric oxide affects preimplantation embryonic development in a rotating wall vessel bioreactor simulating microgravity | Cao YJ, Fan XJ, Shen Z, Ma BH, Duan EK | Cell Biol. Int. 31: 24-29, 2007 |
Numerical Model and Experimental Validation of Microcarrier Motion in a Rotating Bioreactor | Pollack SR, Meaney DF, Levine EM, Litt M, Johnston ED | Tiss Engin 6: 519-530, 2000. |
Nutrition Countermeasure and Immune Function in Microgravity | Kulkarni AD, Yamauchi K. and Pellis NR | Proceedings of the 2nd Pan Pacific Basin Workshop on Microgravity Sciences, Pasadena, CA. April 2001BT1099:1-10, 2001 |
On-Line Measurement of Glucose in a Rotating Wall Perfused Vessel Using an Amperometric Glucose Sensor | Yuanhang Xu, Antony S. Jeevarajan, James M. Gay, Thomas D Taylor, Melody M. Anderson: | J The Electrochemical Society, 149: H103- H106, 2002 |
Optimized Suspension Culture: The Rotating-Wall Vessel | Hammond TG, and Hammond JM | Am J Physiol Renal Physiol 281: F12-F25, 2001 |
Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions | Barrila J, Radtke AL, Crabbé A, Sarker SF, Herbst-Kralovetz MM, Ott CM, Nickerson CA | Nat Rev Microbiol. 2010 Nov;8(11):791-801 |
Oxygen transport and consumption by suspended cells in microgravity: A multiphase analysis | Kwon O, Devarakonda SB, Sankovic JM, Banerjee RK. | Biotechnol Bioeng 99:99-107, 2008 |
RWPV Bioreactor Mass Transport: Earth-Based and in Microgravity | Begley CM, Kleis SJ | Biotechnol Bioeng, 80: 465-76, 2002. |
Regulation of the Response of Caenorhabditis elegans to Simulated Microgravity by p38 Mitogen-Activated Protein Kinase Signaling | Li W, Wang D, Wang D. | Sci Rep. 2018 Jan 16;8(1):857. doi: 10.1038/s41598-018-19377-z |
Responses Of Gravity Level Variations On The NASA JSC Bioreactor System. | Tsao YD, Goodwin TJ, Wolf DA, Spaulding GF | Physiologist 35: Suppl S49-50, 1992.[PubMed ID: 1589533] |
Rotary culture promotes the proliferation of MCF-7 cells encapsulated in three-dimensional collagen-alginate hydrogels via activation of the ERK1/2-MAPK pathway | Zheng H, Tian W, Yan H, Yue L, Zhang Y, Han F, Chen X, Li Y | Biomed Mater. 2012 Feb;7(1):015003. doi: 10.1088/1748-6041/7/1/015003 |
Rotating cell culture systems for human cell culture: human trophoblast cells as a model | Zwezdaryk KJ, Warner JA, Machado HL, Morris CA, Höner zu Bentrup K | J Vis Exp. 2012 Jan 18;(59). pii: 3367. doi: 10.3791/3367. |
Scaffold-free Tissue Formation Under Real and Simulated Microgravity Conditions | Aleshcheva G, Bauer J, Hemmersbach R, Slumstrup L, Wehland M, Infanger M, Grimm D | Basic Clin Pharmacol Toxicol. 2016 Oct;119 Suppl 3:26-33. doi: 10.1111/bcpt.12561. |
Simulated Conditions Of Microgravity Suppress Progesterone Production by Luteal Cells of the Pregnant Rat | Bhat GK, Yang H, Sridaran R: | J Gravit Physiol Dec; 8: 57-66, 2001 |
Simulated Weightlessness in the Design and Exploitation of a NMR-Compatible Bioreactor | Bradamante S, Barenghi L, Villa A | Biotechnol Prog. 20: 1454-1459, 2004. |
Simulated microgravity, erythroid differentiation, and the expression of transcription factor GATA-1 in CD34+ cells. | Zheng L, Liu JZ, Hu YW, Zhong TY, Xiong SL, Wang W, Wang Q. | Aviat Space Environ Med. 82(5):513-7, 2011 |
Simulated microgravity-induced epigenetic changes in human lymphocytes | Singh KP, Kumari R, Dumond JW | J Cell Biochem. 111(1):123-9, 2010 |
Space Immunology and Countermeasure Research in Modeled Microgravity | Kulkarni AD, Yamauchi K. Taga M, Savary CA, Sundaresan A and Pellis NR | Proceedings of the Aerospace Sciences and Conference, AIAA-2002-0325:1-6, 2002 |
Spaceflight and modeled microgravity effects on microbial growth and virulence | Rosenzweig JA, Abogunde O, Thomas K, Lawal A, Nguyen YU, Sodipe A, Jejelowo O | Appl Microbiol Biotechnol 85:885-891, 2010 |
Studying host-pathogen interactions in 3-D: organotypic models for infectious disease and drug development | Nickerson CA, Richter EG, Ott CM | J Neuroimmune Pharmacol. 2:26-31, 2007 |
Synergistic effects of Indian hedgehog and sonic hedgehog on chondrogenesis during cartilage repair | Chen L, Liu G, Li W, Wu X | J Mol Hist (2021);52(2):407-418 |
The Fluid Dynamic and Shear Environment in The NASA/JSC Rotating-Wall Perfused Vessel Bioreactor. | Begley CM and Kleis SJ | Biotechnol Bioeng 70: 32-40, 2000 |
The International Space Station: an Extreme Environment for Key Host-Microbe Discoveries | C. Mark Ott, Thomas Marshburn, and Cheryl A. Nickerson | Microbe—Volume 11, Number 6, 2016, Pages 253-261 |
The Physical Basis of Gravity Stimulus Nullification by Clinostat Rotation | Dedolph RR and Dipert MH | Plant Physiol 47: 756-764, 1971 |
The Rotary Cell Culture System increases NTRK3 expression and promotes neuronal differentiation and migratory ability of neural stem cells cultured on collagen sponge | Cui Y, Yin Y, Zou Y, Zhao Y, Han J, Xu B, Chen B, Xiao Z, Song H, Shi Y, Xue W, Ma X and Dai J | Stem Cell Research & Therapy (2021) 12:298 |
The application of low shear modeled microgravity to 3-D cell biology and tissue engineering | Navran S. | Biotechnol Ann Rev. 14: 275-296, 2008 |
The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis | Acres JM, Youngapelian MJ, and Nadeau J | npj Microgravity (2021) 7:7 |
Three-Dimensional Rotating Wall Vessel-Derived Cell Culture Models for Studying Virus-Host Interactions | Gardner JK, Herbst-Kralovetz MM | Viruses. 2016 Nov 9;8(11). pii: E304 |
Three-dimensional low shear culture of Mycobacterium bovis BCG induces biofilm formation and antimicrobial drug
tolerance | Cantillon D, Wroblewska J, Cooper I, Newport MJ and Waddell SJ | npj Biofilms and Microbiomes (2021) 7:12. |
Three-dimensional low shear culture of Mycobacterium bovis BCG induces biofilm formation and antimicrobial drug tolerance | Cantillon D, Wroblewska J, Cooper I, Newport MJ and Waddell SJ | npj Biofilms and Microbiomes 2021; 7:12 |
Tissue Culture in Microgravity | Duray PH, Hatfill SJ and Pellis NR | Science & Medicine, 4: 45-55, 1997 |
Xenopus development from late gastrulation to feeding tadpole in simulated microgravity | Olson WM, Wiens DJ, Gaaul TL, Rodriguez M, Hauptmeier CL | Intl J Dvl Biol. ;54:167-74. |
β-Adrenergic stimuli and rotating suspension culture enhance conversion of human adipogenic mesenchymal stem cells into highly conductive cardiac progenitors | Islas JF,, Abbasgholizadeh R, Dacso C, Potaman VN, Navran S, Bond RA, Iyer D, Birla R, Schwartz RJ | J Tissue Eng Regen Med. 2020; 14:306-318 |
“Modeled Microgravity” Affects Cell Response to Ionizong Radiation and Increase Genomic Damage. | Canova S, Fiorasi F, Mognato M, Grifalconi M, Reddi E, Russo A, Celotti L | Radiat Res 163: 191-199, 2005. |
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