A validated model of GAG deposition, cell distribution and growth of tissue engineered cartilage cultured in a rotating bioreactor | Nikolaev NI, Obradovic B, Versteeg HK, Lemon G, Williams DJ | Biotechnol Bioeng, 2010; 105:842-853 |
Adjacent Tissue (Cartilage, Bone) Affect the Functional Integration of Engineered Calf Cartilage in vitro | Tognana E, Chen F, Padera RF, Leddy HA, Christensen SE, Guilak F, Vunjak-Novakovic G, Freed LE | Osteoarthritis and Cartilage, 2005; 13:129-138 |
An ex vivo model for chondrogenesis and osteogenesis | Pound JC, Green DW, Roach HI, Mann S, Oreffo RO | Biomaterials, 2007; 28:2839-2849 |
Articular Cartilage Bioreactors and Bioprocesses | Darling EM, Athanasiou KA | |
Bioreactor Cultivation Conditions Modulate the Composition and Mechanical Properties of Tissue-Engineered Cartilage | Vunjak-Novakovic G, Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, Freed LE | J Orthop Res, 1999; 17:130-138 |
Bioreactor Studies of Native and Tissue Engineered Cartilage | Vunjak-Novakovic G, Obradovic B, Martin I, Freed LE | Biorheology, 2002; 39:259-268 |
Bioreactors Mediate the Effectiveness of Tissue Engineering Scaffolds | Pei M, Solchaga LA, Seidel J, Zenf L, Vunjak-Novakovic G, Caplan AI, Freed LE | |
Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds, and rotating bioreactors | Marolt D, Augst A, Freed LE, Vepari C, Fajardo R, Patel N, Gray M, Farley M, Kaplan D, Vunjak-Novakovic G | Biomaterials, 2006; 27:6138-6149 |
Cartilaginous tissue formation from bone marrow using rotating wall vessel (RWV) bioreactor | Ohyabu Y, Kida N, Kojima H, Taguchi T, Tanaka J, Uemura T | Biotechnol Bioeng, 2006; 95:1003-1008 |
Cell-Nanofiber-Based Cartilage Tissue Engineering Using Improved Cell Seeding, Growth Factor, and Bioreactor Technologies | | Tissue Eng Part A, 2008; 14:639-648 |
Characteristics of mesenchymal stem cells derived from Wharton’s jelly of human umbilical cord and for fabrication of non-scaffold tissue-engineered cartilage | Liu S, Hou KD, Yuan M, Peng J, Zhang L, Sui X, Zhao B, Xu W, Wang A, Lu S, Guo Q | J Biosci Bioeng, 2013 Jul 27 |
Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions | Sheehy EJ, Buckley CT, Kelly DJ | J Tissue Eng Regen Med, 2011 Oct; 5(9):747-58 |
Chondrogenesis in Aggregates of Embryonic Limb Cells Grown in a Rotating Wall Vessel | Duke PJ, Daane E, Arizpe J, Montufar-Solis D | Adv Space Res, 1996; 17:289-293 |
Chondrogenesis in a Cell-Polymer Bioreactor system | | Exp Cell Res, 1998; 240:58-65 |
Chondrogenesis of Aged Human Articular Cartilage in a Scaffold-Free Bioreactor | Marlovits S, Tichy B, Truppe M, Gruber D, Vecsei V | Tissue Eng, 2003; 9:1215-1226 |
Chondrogenic differentiation of human adipose-derived stem cells using microcarrier and bioreactor combination technique | Kang H, Lu S, Peng J, Yang Q, Liu S, Zhang L, Huang J, Sui X, Zhao B, Wang A, Xu W, Guo Q, Song Q | |
Coculture of meniscus cells and mesenchymal stem cells in simulated microgravity | Weiss WM, Mulet-Sierra A, Kunze M, Jomha NM, Adesida AB | NPJ Microgravity, 2017 Nov 10; 3:28 |
Collagen Expression in Tissue Engineered Cartilage of Aged Human Articular Chondrocytes in a Rotating Bioreactor | Marlovits S, Tichy B, Truppe M, Gruber D, Schlegel W | Int J Artif Organs, 2003; 26:319-330 |
Collagen in Tissue-Engineered Cartilage: Types Structure, and Crosslinks | Riesle J, Hollander AP, Langer R, Freed LE, Vunjak-Novakovic G | J Cell Biochem, 1998; 71:313-27 |
Computational fluid dynamics modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering | Cinbiz MN, Tığli RS, Beşkardeş IG, Gümüşderelioğlu M, Colak U | J Biotechnol, 2010; 150(3):389-95 |
Cross-linking density alters early metabolic activities in chondrocytes encapsulated in poly(ethylene glycol) hydrogels and cultured in the rotating wall vessel | Villanueva I, Klement BJ, Von Deutsch D, Bryant SJ | Biotechnol Bioeng, 2009; 102:1242-50 |
Cultivation of Cell-Polymer Cartilage Implants in Bioreactors | Freed LE, Vunjak-Novakovic G, Langer R | J Cell Biochem, 1993; 51:257-64 |
Culture of Human Septal Chondrocytes in a Rotary Bioreactor | Reuther MS, Wong VW, Briggs KK, Chang AA, Nguyen QT, Schumacher BL, Masuda K, Sah RL, Watson D | Otolaryngol Head Neck Surg, 2012 Oct; 147(4):661-7 |
Development and remodeling of engineered cartilage-explant composites in vitro and in vivo | Tognana E, Padera RF, Chen F, Vunjak-Novakovic G, Freed LE | Osteoarthritis and Cartilage, 2005; 13:896-905 |
Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds, and bioreactors | August A, Marolt D, Freed LE, Vepari C, Meinel L, Farley M, Fajardo R, Patel M, Gray M, Kaplan DL, Vunjak-Novakovic G | J R Soc Interface, 2008; 5(25):929-39 |
Effects of collagen matrix and bioreactor cultivation on cartilage regeneration of a full-thickness critical-size knee joint cartilage defects with subchondral bone damage in a rabbit model | Wang KH, Wan R, Chiu LH, Tsai YH, Fang CL, Bowley JF, Chen KC, Shih HN, Lai WT | |
Engineering of Functional Cartilage Tissue Using Stem Cells from Synovial Lining: A Preliminary Study | Pei M, He F, Kish VL, Vunjak-Novakovic G | Clin Orthop Relat Res, 2008; 466:1880-1889 |
Engineering of rat articular cartilage on porous sponges: effects of tgf Beta 1 and microgravity bioreactor culture | Emin N, Koc A, Durkut S, Elcin AE, Elcin YM | Artif Cells Blood Substit Immobil Biotechnol, 2008; 36:123-137 |
Flexural properties of native and tissue-engineered human septal cartilage | Caffrey JP, Kushnaryov AM, Reuther MS, Wong VW, Briggs KK, Masuda K, Sah RL, Watson D | Otolaryngol Head Neck Surg, 2013 Apr; 148(4):576-81 |
Frontiers in Tissue Engineering – In Vitro Modulation of Chondrogenesis | Freed L, Martin I, Vunjak-Novakovic G | Clin Orthop Relat Res, 1999; 367S |
Functional tissue-engineered microtissue derived from cartilage extracellular matrix for articular cartilage regeneration | Yin H, Wang Y, Sun X, Cui G, Sun Z, Chen P, Xu Y, Yuan X, Meng H, Xu W, Wang A, Guo Q, Lu S, Peng J | Acta Biomater, 2018; 77:127-141 |
Gas Exchange is Essential for Bioreactor Cultivation of Tissue Engineered Cartilage | Obradovic B, Carrier R, Vunjak-Novakovic G, Freed LE | Biotechnol Bioeng, 1999; 63:197-205 |
Generating mechanically stable, pediatric, and scaffold-free nasal cartilage constructs in vitro | Akbari P, Waldman SD, Propst E, Cushing SL, Weber JF, Yeger H, Farhat WA | Tissue Eng Part C Methods, 2016 Nov 9 |
Growth factors for sequential cellular de-and re-differentiation in tissue engineering | Pei M, Seidel J, Vunjak-Novakovic G, Freed LE | Biochem Biophys Res Commun, 2002; 294:149-154 |
Growth of Tissue-Engineered Human Nasoseptal Cartilage in Simulated Microgravity | | Arch Otolaryngol Head Neck Surg, 2000; 126:759-765 |
Human elastic cartilage engineering from cartilage progenitor cells using rotating wall vessel bioreactor | Takebe T, Kobayashi S, Kan H, Suzuki H, Yabuki Y, Mizuno M, Adegawa T, Yoshioka T, Tanaka J, Maegawa J, Taniguchi H | Transplant Proc, 2012 May; 44(4):1158-61 |
IGF-I and Mechanical Environment Interact to Modulate Engineered Cartilage Development | Gooch KJ, Blunk T, Courter DL, Sieminski AL, Bursac PM, Vunjak-Novakovic G, Freed LE | Biochem Biophys Res Commun, 2001; 286:909-15 |
Induction of mesenchymal stem cell chondrogenic differentiation and functional cartilage microtissue formation for in vivo cartilage regeneration by cartilage extracellular matrix-derived particles | Yin H, Wang Y, Sun Z, Sun X, Xu Y, Li P, Meng H, Yu X, Xiao B, Fan T, Wang Y, Xu W, Wang A, Guo Q, Peng J, Lu S | Acta Biomater, 2016 Jan 20 |
LRP receptors in chondrocytes are modulated by simulated microgravity and cyclic hydrostatic pressure | Nordberg RC, Mellor LF, Krause AR, Donahue HJ, Loboa EG | |
Low-density Cultures of Bovine Chondrocytes: Effects of Scaffold Material and Culture System | | Biomaterials, 2005; 26:2001-2012 |
Methods for studying MLO-Y4 osteocytes in collagen-hydroxyapatite scaffolds in the rotary cell culture system | | Connect Tissue Res, 2021; 62(4):436-453 |
Modulation of the Mechanical Properties of Tissue Engineered Cartilage | Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, Freed LE, Vunjak-Novakovic G | Biorheology, 2000; 37:141-7 |
Numerical Simulation of Mass Transfer and Three-Dimensional Fabrication of Tissue-Engineered Cartilages Based on Chitosan/Gelatin Hybrid Hydrogel Scaffold in a Rotating Bioreactor | Zhu Y, Song K, Jiang S, Chen J, Tang L, Li S, Fan J, Wang Y, Zhao J, Liu T | Appl Biochem Biotechnol, 2016 Aug 15 |
One-step articular cartilage repair: combination of in situ bone marrow stem cells with cell-free poly(L-lactic-co-glycolic acid) scaffold in a rabbit model | Shi J, Zhang X, Zeng X, Zhu J, Pi Y, Zhou C, Ao Y | Orthopedics, 2012 May; 35(5) |
Optimal 3D culture of primary articular chondrocytes for use in the rotating wall vessel bioreactor | Mellor LF, Baker TL, Brown RJ, Catlin LW, Oxford JT | Aviat Space Environ Med, 2014 Aug; 85(8):798-804 |
Pediatric laryngotracheal reconstruction with tissue-engineered cartilage in a rabbit model | Jacobs IN, Redden RA, Goldberg R, Hast M, Salowe R, Mauck RL, Doolin EJ | Laryngoscope, 2016 Jan; 126 Suppl 1 |
Rotating three-dimensional dynamic culture of adult human bone marrow-derived cells for tissue engineering of hyaline cartilage | Sakai S, Mishima H, Ishii T, Akaogi H, Yoshioka T, Ohyabu Y, Chang F, Ochiai N, Uemura T | J Orthop Res, 2009; 27:517-21 |
Simulated microgravity using a rotary cell culture system promotes chondrogenesis of human adipose-derived mesenchymal stem cells via the p38 MAPK pathway | Yu B, Yu D, Cao L, Zhao X, Long T, Liu G, Tang T, Zhu Z | Biochem Biophys Res Commun, 2011 Oct; 414(2):412-8 |
Sonic hedgehog promotes chondrogenesis of rabbit bone marrow stem cells in a rotary cell culture system | Chen L, Liu G, Li W, Wu X | BMC Dev Biol, 2019; 19(1):18 |
Strategies to Promote Chondrogenesis and Osteogenesis from Human Bone Marrow Cells and Articular Chondrocytes Encapsulated in Polysaccharide Templates | Pound JC, Green DW, Chaudhuri JB, Mann S, Roach HI, Oreffo RO | Tissue Eng, 2006; 12:2789-2799 |
Studies of Chondrogenesis in Rotating Systems | Duke PJ, Daane EL, Montufar-Solis D | J Cell Biochem, 1993; 51:274-282 |
Synergistic effects of Indian hedgehog and sonic hedgehog on chondrogenesis during cartilage repair | Chen L, Liu G, Li W, Wu X | J Mol Hist, 2021; 52(2):407-418 |
The effect of the microgravity rotating culture system on the chondrogenic differentiation of bone marrow mesenchymal stem cells | Wu X, Li SH, Lou LM, Chen ZR | Mol Biotechnol, 2013 Jun; 54(2):331-6 |
Three Dimensional Culture of Bovine Chondrocytes in Rotating-Wall Vessels | | In Vitro Cell Dev Biol Anim, 1997; 33:358-365 |
Tissue Engineering with Chondrocytes | | Facial Plast Surg, 2002; 18:59-68 |
Transfection of the IHH gene into rabbit BMSCs in a simulated microgravity environment promotes chondrogenic differentiation and inhibits cartilage aging | Liu PC, Liu K1, Liu JF, Xia K, Chen LY, Wu X | Oncotarget, 2016 Sep 6; 7(39):62873-62885 |
