A Study of Alterations in DNA Epigenetic Modifications (5mC and 5hmC) and Gene Expression Influenced by Simulated Microgravity in Human Lymphoblastoid Cells | Chowdhury B, Seetharam A, Wang Z, Liu Y, Lossie AC, Thimmapuram J, Irudayaraj J | PLoS One, 2016 Jan 28; 11(1) |
Alveolar epithelium protects macrophages from quorum sensing-induced cytotoxicity in a three-dimensional co-culture model | Crabbé A, Sarker SF, Van Houdt R, Ott CM, Leys N, Cornelis P, Nickerson CA | Cell Microbiol, 2011 Mar; 13(3):469-81 |
Analysis of miRNA and mRNA expression profiles highlights alterations in ionizing radiation response of human lymphocytes under modeled microgravity | Girardi C, De Pittà C, Casara S, Sales G, Lanfranchi G, Celotti L, Mognato M | |
Attenuation of Antiviral Immune Response Caused by Perturbation of TRIM25-Mediated RIG-I Activation under Simulated Microgravity | Zhu L, Nie L, Xie S, Li M, Zhu C, Qiu X, Kuang J, Liu C, Lu C, Li W, Meng E, Zhang D, Zhu L | Cell Reports, 2021; 34, 108600 |
Cellular and genetic adaptation in low-gravity environments | | Ann N Y Acad Sci, 2009; 1161:135-46 |
Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions | Sheehy EJ, Buckley CT, Kelly DJ | J Tissue Eng Regen Med, 2011 Oct; 5(9):747-58 |
Cordyceps Sinensis Enhances Lymphocyte Proliferation and CD Markers Expression in Simulated Microgravity Environment | Hao T, Li JJ, DU ZY, Duan CM, Wang YM, Wang CY, Song JP, Wang LJ, Li YH, Wang Y | Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2012 Oct; 20(5):1212-5 |
Dynamic culture in a rotating-wall vessel bioreactor differentially inhibits murine T-lymphocyte activation by mitogenic stimuli upon return to static conditions in a time-dependent manner | Simons DM, Gardner EM, Lelkes PI | J Appl Physiol, 2006; 100:1287-1292 |
Early exposure of murine embryonic stem cells to hematopoietic cytokines differentially directs definitive erythropoiesis and cardiomyogenesis in alginate hydrogel three-dimensional cultures | Fauzi I, Panoskaltsis N, Mantalaris A | Stem Cells Dev, 2014 Jun 13 |
Effect of Simulated Microgravity on the Production of IL-12 by PBMC’s | Bakos A, Varkonyi A, Minarovits J, Batkai L | J Gravit Physiol, 2002; 9:293-294 |
Effect of lentinan against immunosuppression of lymphocytes cultured in simulated microgravity environment | Hao T, Wang YM, Li JJ, Du ZY, Duan CM, Wang CY, Song JP, Wang LJ, Li YH, Wang Y | Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2012 Feb; 20(1):182-6 |
Erythroid Cell Growth and Differentiation In Vitro in the Simulated Microgravity Environment of the NASA Rotating Wall Vessel Bioreactor | | In Vitro Cell Dev Biol Anim, 2001; 37:79-83 |
Experimental study on effect of simulated microgravity on structural chromosome instability of human peripheral blood lymphocytes | Wei L, Liu C, Kang L, Liu Y, Shi S, Wu Q, Li Y | PLoS One, 2014 Jun 25; 9(6) |
Functional recovery of peripheral blood mononuclear cells in modeled microgravity | Ritz BW, Lelkes PI, Gardner EM | FASEB J, 2006; 20:305-307 |
Gene expression alterations in activated human T-cells induced by modeled microgravity | Ward NE, Pellis NR, Risin SA, Risin D | J Cell Biochem, 2006; 99:1187-1202 |
Human immune system adaptations to simulated microgravity revealed by single‑cell mass cytometry | Spatz JM, Hughes Fulford M, Tsai A, Gaudilliere D, Hedou J, Ganio E, Angst M, Aghaeepour N, Gaudilliere B | Scientific Reports, 2021; 11:11872 |
Impact of Modeled Microgravity on Migration, Differentiation, and Cell Cycle Control of Primitive Human Hematopoietic Progenitor Cells | Plett PA, Abonour R, Frankovitz SM, Orschell CM | Experimental Hematology, 2004; 32:773-781 |
Integrated Biophysical and Biochemical Signals Augment Megakaryopoiesis and Thrombopoiesis in a Three-Dimensional Rotary Culture System | Yang Y, Liu C, Lei X, Wang H, Su P, Ru Y, Ruan X, Duan E, Feng S, Han M, Xu Y, Shi L, Jiang E, Zhou J | Stem Cells Transl Med, 2015 Dec 23 |
Integration Analysis of MicroRNA and mRNA Expression Profiles in Human Peripheral Blood Lymphocytes Cultured in Modeled Microgravity | Girardi C, De Pittà C, Casara S, Calura E, Romualdi C, Celotti L, Mognato M | Biomed Res Int, 2014; 2014:296747 |
Microgravity control of autophagy modulates osteoclastogenesis | Sambandam Y, Townsend MT, Pierce JJ, Lipman CM, Haque A, Bateman TA, Reddy SV | |
Microgravity inhibition of lipopolysaccharide-induced tumor necrosis factor-α expression in macrophage cells | Wang C, Luo H, Zhu L, Yang F, Chu Z, Tian H, Feng M, Zhao Y, Shang P | Inflamm Res, 2014 Jan; 63(1):91-8 |
Multiple Interleukin-2 Signaling Pathways Differentially Regulated by Microgravity | | Immunopharmacology, 1999; 44:273-9 |
Novel alginate three-dimensional static and rotating culture systems for effective ex vivo amplification of human cord blood hematopoietic stem cells and in vivo functional analysis of amplified cells in NOD/SCID mice | Yuan Y, Sin WY, Xue B, Ke Y, Tse KT, Chen Z, Xie Y, Xie Y | |
Proliferation of Human Hematopoietic Bone Marrow Cells in Simulated Microgravity | Plett PA, Frankovitz SM, Abonour R, Orschell-Traycoff CM | In Vitro Cell Dev Biol Anim, 2001; 37:73-78 |
Prolonged exposure to simulated microgravity diminishes dendritic cell immunogenicity | Tackett N, Bradley JH, Moore EK, Baker SH, Minter SL, DiGiacinto B, Arnold JP, Gregg RK | Sci Rep, 2019; 9(1):13825 |
Properties of mechano-transduction via simulated microgravity and its effects on intracellular trafficking of VEGFR's | Puca A, Russo G, Giordano A | Oncotarget, 2012 Apr; 3(4):426-34 |
Simulated Microgravity Impairs Respiratory Burst Activity in Human Promyelocytic Cells | | In Vitro Cell Dev Biol Anim, 2001; 37:209-215 |
Simulated microgravity decreases DNA repair capacity and induces DNA damage in human lymphocytes | Kumari R, Singh KP, Dumond JW Jr | J Cell Biochem, 2009; 107:723-31 |
Simulated microgravity increases heavy ion radiation-induced apoptosis in human B lymphoblasts | Dang B, Yang Y, Zhang E, Li W, Mi X, Meng Y, Yan S, Wang Z, Wei W, Shao C, Xing R, Lin C | |
Simulated microgravity-induced epigenetic changes in human lymphocytes | | J Cell Biochem, 2010; 111:123-129 |
Simultaneous expansion and harvest of hematopoietic stem cells and mesenchymal stem cells derived from umbilical cord blood | Kedong S, Xiubo F, Tianqing L, Macedo HM, LiLi J, Meiyun F, Fangxin S, Xuehu M, Zhanfeng C | |
Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early t-cell activation | Martinez EM, Yoshida MC, Candelario TT, Hughes-Fulford M | Am J Physiol Regul Integr Comp Physiol, 2015 Jan 7 |
Sub-mitogenic phorbol myristate acetate co-stimulation rescues the PHA-induced activation of both naïve and memory T cells cultured in the rotating-wall vessel bioreactor | Simmons DM, Gardner EM, Lelkes PI | Cell Biol Int, 2009; 33:882-6 |
Synergistic Effects of Incubation in Rotating Bioreactors and Cumulative Low Dose 60 Co γ-ray Irradiation on Human Immortal Lymphoblastoid Cells | Wei L, Han F, Yue L, Zheng H, Yu D, Ma X, Cheng H, Li Y | Microgravity Science and Technology, 2012 Nov; 24(5): 335-344 |
Synergistic Effects of Weightlessness, Isoproterenol, and Radiation on DNA Damage Response and Cytokine Production in Immune Cells | Moreno-Villanueva M, Feiveson AH, Krieger S, Brinda AK, von Scheven G, Bürkle A, Crucian B, Wu H | Int. J. Mol. Sci., 2018; 19: 3689 |
T cell resistance to activation by dendritic cells requires long-term culture in simulated microgravity | Bradley JH, Stein R, Randolph B, Molina E, Arnold JP, Gregg RK | Life Sci Space Res (Amst), 2017 Nov; 15:55-61 |
The effect of simulated microgravity on human mesenchymal stem cells cultured in an osteogenic differentiation system: a bioinformatics study | Sheyn D, Pelled G, Netanely D, Domany E, Gazit D | Tissue Eng Part A, 2010; 16(11):3403-12 |
The influence of leptin on the activity of lung lymphocytes under simulated microgravity | | Eur J Appl Physiol, 2009; 107:335-44 |
Three-Dimensional Binding of Epidermal Growth Factor Peptides in Colonic Tissues Produced From Rotating Bioreactor | Kaeffer B, Trubuil A, Kervrann C, Pardini L, Cherbut C | In Vitro Cell Dev Biol Anim, 2002; 38:436-439 |
