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Research Publications / Liver/ Pancreas

A Unique Cytoplasmic Marker for Extratesticular Sertoli Cells
Cameron DF, Hushen JJ, Dejarlais T, Colado L, Wolski KM, Sanberg PR, Saporta S
Cell Transplant 2002; 11:507-512
Altered TNF-Alpha, Glucose, Insulin, and Amino Acids in Islets of Langerhans Cultured in a Microgravity Model System
Tobin BW, Leeper-Woodfored SK, Hashemi BB, Smith SM, Sams CF
Am J Physiol Endocrinol Metab 2001; 280
Antiproliferation activity of Devil's club (Oplopanax horridus) and anticancer agents on human pancreatic cancer multicellular spheroids
Tai J, Cheung SS, Ou D, Warnock GL, Hasman D
Phytomedicine. 2013
Cultures of Human Liver Cells in Simulated Microgravity Environment
Yoffe B, Darlington GJ, Soriano HE, Krishman B, Risin D, Pellis NR, Khaustov VI
Adv Space Res 1999; 24:829-836
Direct orthotopic implantation of hepatic organoids
Zhou VX, Lolas M, Chang TT
J Surg Res. 2017; 211:251-260
Dynamic expression patterns of differential proteins during early invasion of hepatocellular carcinoma
Chen RX, Song HY, Dong YY, Hu C, Zheng QD, et al.
PLoS One. 2014; 9(3)
Effects of Microgravity on the Embryonic Pancreas
Rose MI, Brown DC, Pellis NR, Crisera CA, Colen KL, Longaker MT, Gottes GK
In Vitro Cell Dev Biol Anim 1999; 35:560-563
Experimental Study of Rat Beta Islet Cells Cultured under Simulated Microgravity Conditions
Song C, Duan XQ, Li X, Han LO, Xu P, Song CF, Jin LH
Acta Biochim Biophys (Shanghai) 2004; 36:47-50
Experimental Study on Islet Cells in Rats Under Condition of Three-dimensional Microgravity
Song C, Duan XQ, Li X, Han LO, Xu P, Song CF, Jin LH
Zhonghua Wai Ke Za Zhi 2004; 42:559-561
Formation of Insulin-Secreting, Sertoli-Enriched Tissue Constructs by Microgravity Cocultures of Isolated Pig Islets and Rat Sertoli Cells
Cameron DF, Hushen JJ, Nazian SJ
In Vitro Cell Dev Biol Anim 2001; 37:490-498
Genome-wide gene expression profiling of microgravity effect on human liver cells
Clement JQ, Lacy SM, Wilson BL
J Gravit Physiol 2007; 14
Hetero-cellular prototyping by synchronized multi-material bioprinting for rotary cell culture system
Snyder J, Son AR, Hamid Q, Wu H, Sun W
Biofabrication. 2016; 8(1):015002
Immature syngeneic dendritic cells potentiate tolerance to pancreatic islet allografts depleted of donor dendritic cells in microgravity culture condition
Stepkowski SM, Phan T, Zhang H, Bilinski S, Kloc M, Qi Y, Katz SM, Rutzky LP
Transplantation 2006; 82:1756-1763
In-vitro reconstitution of hepatic tissue architecture with neonatal mouse liver cells using three-dimensional culture
Okamura A, Zheng YW, Hirochika R, Tanaka J, Taniguchi H
J Nanosci Nanotechnol 2007; 7:721-725
Induction of Three-Dimensional Assembly of Human Liver Cells by Simulated Microgravity
Khaoustov VI, Darlington GJ, Soriano HE, Krishnan B, Risin D, Pellis NR, Yoffe B
In Vitro Cell Dev Biol Anim 1999; 35:501-509
Labeling of primary human hepatocytes with micron-sized iron oxide particles in suspension culture suitable for large-scale preparation
Kammer NN, Billecke N, Morgul MH, Adonopoulou MK, Mogl M, Huang MD, Florek S, Schmitt KR, Raschzok N, Sauer IM
Artif Organs. 2011
Liver-Tumor Hybrid Organoids for Modeling Tumor Growth and Drug Response In Vitro
Skardal A, Devarasetty M, Rodman C, Atala A, Soker S
Ann Biomed Eng. 2015
Low gravity rotational culture and the integration of immunomodulatory stem cells reduce human islet allo-reactivity
Qureshi KM, Lee J, Paget MB, Bailey CJ, Curnow SJ, Murray HE, Downing R
Clin. Transplant. 2015; 29(1):90-8
Low-shear modeled microgravity environment maintains morphology and differentiated functionality of primary porcine hepatocyte cultures
Nelson LJ, Walker SW, Hayes PC, Plevris JN
Cells Tissues Organs. 2010; 192:125-140
Maintenance of Liver Functions in Rat Hepatocytes Cultured as Spheroids in a Rotating Wall Vessel
Brown LA, Arterburn LM, Miller AP, Cowger NL, Hartley SM, Andrews A, Silber PM, Li AP
In Vitro Cell Dev Biol Anim 2003; 39:13-20
Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy
Devarasetty M, Wang E, Soker S, Skardal A
Biofabrication. 2017; 9(2):5090
Microarray Analysis of Genes Differentially Expressed in HEPG2 Cells Cultured in Simulated Microgravity: Preliminary Report
Khaoustov VI, Risin D, Pellis NR, Yoffe B
In Vitro Cell Dev Biol Anim 2001; 37:84-88
Microgravity Culture Conditions Decrease Immunogenicity but Maintain Excellent Morphology of Pancreatic Islets
Rutzky L, Kloc M, Bilinski S, Phan T, Zhang H, Stepkowski SM, Katz S
Transplant Proc 2001; 33:388
Microgravity Culture Conditions Reduces Immunogenicity And Improves Function Of Pancreatic Islets
Rutzky L, Bilinzki Z, Kloc M, Phan T, Zhang H, Katz S, Stepkowski S
Transplantation 2002; 74:13-21
Microgravity as a means to incorporate HepG2 aggregates in polysaccharide-protein hybrid scaffold
Sarika PR, James NR, Anilkumar PR, Raj DK, Kumary TV
J Mater Sci Mater Med. 2016; 27(2):27
Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates
Chang TT, Hughes-Fulford M
Biomaterials. 2014; 35(7):2162-71
Preservation of glucose responsiveness in human islets maintained in a rotational cell culture system
Murray HE, Padget MB, Downing R
Mol Cell Endocrinol 2005; 238:39-49
Progressive Maturation Resistance to Microcystin-LR Cytotoxicity in Two Different Hepatospheroidal Models
Battle T, Maguire T, Moulsdale H, Doyle A
Cell Biol Toxicol 1999; 15:3-12
Proliferation Rates of HepG2 Cells Encapsulated in Alginate Are Increased in a Microgravity Environment Compared With Static Cultures
Coward SM, Selden C, Mantalaris A, Hodgson HJ
Artif Organs 2005; 29:152-158
Reconstitution of hepatic tissue architectures from fetal liver cells obtained from a three-dimensional culture with a rotating wall vessel bioreactor
Ishikawa M, Sekine K, Okamura A, Zheng YW, Ueno Y, Koike N, Tanaka J, Taniguchi H
J Biosci Bioeng. 2011
Replication of hepatitis E virus in three-dimensional cell culture
Berto A, Van der Poel WH, Hakze-van der Honing R, Martelli F, La Rogione RM, et al.
J Virol Methods. 2013; 187(2):327-32
Rotary Cell Culture System (RCCS): A New Method for Cultivation Hepatocytes on Microcarriers
Mitteregger R, Vogt G, Rossmanith E, Falkenhagen D
Int J Artif Organs 1999; 22:816-822
Rotating microgravity-bioreactor cultivation enhances the hepatic differentiation of mouse embryonic stem cells on biodegradable polymer scaffolds
Wang Y, Zhang Y, Zhang S, Peng G, Liu T, Li Y, Xiang D, Wassler MJ, Shelat HS, Geng Y
Tissue Eng Part A. 2012
Rotational Transport of Islets: The Best Way for Islets to Get around?
Oberhuber R, Mittermair C, Zelger B, Pirkebner D, Draxl A, et al.
Biomed Res Int. 2013; 2013:975608
Rotational co-culture of clonal β-cells with endothelial cells: effect of PPAR-γ agonism in vitro on insulin and VEGF secretion
Paget MB, Murray HE, Bailey CJ, Flatt PR, Downing R
Diabetes Obes Metab. 2011
Rotational culture and integration with amniotic stem cells reduce porcine islet immunoreactivity in vitro and slow xenorejection in a murine model of islet transplantation
Zafar A, Lee J, Yesmin S, Paget MB, Bailey CJ, Murray HE, Downing R
Xenotransplantation 2019; e12508
Screening candidate metastasis-associated genes in three-dimensional HCC spheroids with different metastasis potential
Chen R, Dong Y, Xie X, Chen J, Gao D, Liu Y, Ren Z, Cui J
Int J Clin Exp Pathol. 2014; 7(5):2527-35
Selection of Scaffolds of Rat Hepatocytes in Three-dimensional Culture Under Simulated Microgravity
Zhang SQ, Gao SJ, Jiang QY, Lao QL, Feng DY
Shi Yan Sheng Wu Xue Bao 2004; 37:67-71
Simulated microgravity combined with polyglycolic Acid scaffold culture conditions improves the function of pancreatic islets
Song Y, Wei Z, Song C, Xie S, Feng J, Fan J, Zhang Z, Shi Y
Biomed Res Int. 2013; 2013:150739
Simulated microgravity promotes the formation of tridimensional cultures and stimulates pluripotency and a glycolytic metabolism in human hepatic and biliary tree stem/progenitor cells
Costantini D, Overi D, Casadei L, Cardinale V, Nevi L, Carpino G, Di Matteo S, Safarikia S, Valerio M, Melandro F, Bizzarri M, Manetti C, Berloco PB, Gaudio E, Alvaro D
Sci Rep. 2019; 9(1):5559
The Simulated Microgravity Environment Maintains Key Metabolic Functions and Promotes Aggregation of Primary Porcine Hepatocytes
Dabos KJ, Nelson LJ, Bradnock TJ, Parkinson JA, Sadler IH, Hayes PC, Plevris JN
Biochem Biophys Acta 2001; 1526:119-130
Three-dimensional Huh7 cell culture system for the study of Hepatitis C virus infection
Sainz B Jr, TenCate V, Uprichard SL
Virol J 2009; 6:103
Transplantation of sertoli-islet cell aggregates formed by microgravity: prolonged survival in diabetic rats
Han X, Qui L, Zhang Y, Kong Q, Wang H, Wang H, Li H, Duan C, Wang Y, Song Y, Wang C
Exp Biol Med (Maywood) 2009; 234:595-603
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