A New Dimension in Modeling Infectious Disease | | ASM News 2004; 70:169-175 |
A Novel Quantitative Biosystem to Model Physiological Fluid Shear Stress on Cells | Nauman EA, Ott CM, Sander E, Tucker DL, Pierson D, Wilson JW, Nickerson CA | Appl Environ Microbiol 2006; 73:699-705 |
A Potential Cause for Kidney Stone Formation During Space Flights: Enhanced Growth of Nanobacteria in Microgravity | Ciftcioglu N, Haddad RS, Golden DC, Morrison DR, McKay DS | Kidney Int 2005; 67:483-491 |
A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance | McConkey CA, Delorme-Axford E, Nickerson CA, Kim KS, Sadovsky Y, Boyle JP, Coyne CB | |
A three-dimensional tissue culture model for the study of attach and efface lesion formation by enteropathic and enterohaemorrhagic Escherichia coli | Carvalho HM, Teel LD, Goping G, O’Brien AD | Cell Microbiol 2005; 7:1771-1781 |
A549 Lung Epithelial Cells Grown as Three-Dimensional Aggregates: Alternative Tissue Culture Model for Pseudomonas Aeruginosa Pathogenesis | Carterson AJ, Honer zu Bentrup K, Ott CM, Clarke MS, Pierson DL, Vanderburg CR, Buchanan KL, Nickerson CA, Schurr MJ | Infect Immun 2005; 73:1129-1140 |
Alveolar epithelium protects macrophages from quorum sensing-induced cytotoxicity in a three-dimensional co-culture model | Crabbé A, Sarker SF, Van Houdt R, Ott CM, Leys N, Cornelis P, Nickerson CA | Cell Microbiol 2011 Mar; 13(3):469-81 |
Analysis of Interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells | Radtke AL, Wilson JW, Sarker S, Nickerson CA | |
Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lungepithelial model and the influence of fetal bovine serum | Crabbé A, Liu Y, Matthijs N, Rigole P, De La Fuente-Núñez C, Davis R, Ledesma MA, Sarker S, Van Houdt R, Hancock RE, Coenye T, Nickerson CA | Sci Rep 2017 Mar 3; 7:43321 |
Bacillus thuringiensis conjugation in simulated microgravity | Beuls E, Van Houdt R, Leys Y, Dijkstra CL, Larkin O, Mahillon J | Astrobiology 2009; 9:797-805 |
Bacteria in the vaginal microbiome alter the innate immune response and barrier properties of the human vaginal epithelia in a species-specific manner | Doerflinger SY, Throop AL, Herbst-Kralovetz MM | J Infect Dis 2014 Jun 15; 209(12):1989-99 |
Characterization of Escherichia coli MG1655 grown in a low shear modeled microgravity environment | Tucker DL, Ott CM, Huff S, Fofanov V, Willson RC, Fox GE | BMC Microbiology 2007; 7:15 |
Conservation of the Low-shear Modeled Microgravity Response in Enterobacteriaceae and Analysis of the trp Genes in this Response | Soni A, O'Sullivan L, Quick LN, Ott C, Nickerson CA, Wilson JW | Open Microbiol J 2014 Jun 13; 8:51-8 |
Detection of epithelial-cell injury, and quantification of infection, in the HCT-8 organoid model of Cryptosporidiosis | Warren CA, Destura RV, Sevilleja JEAD, Barroso LF, Carvalho H, Barrett LJ, O’Brien AD, Guerrant RL | J Infect Dis 2008; 198:143-149 |
Effect of Microgravity on Fungistatic Activity of an α-Aminophosphonate Chitosan Derivative against Aspergillus niger | Kesavan Devarayan, Yesupatham Sathishkumar, Yang Soo Lee, Byoung-Suhk Kim | |
Effect of Shear Stress on Pseudomonas aeruginosa Isolated from the Cystic Fibrosis Lung | Dingemans J, Monsieurs P, Yu SH, Crabbé A, Förstner KU, Malfroot A, Cornelis P, Van Houdt R | MBio 2016 Aug 2; 7(4). pii: e00813-16 |
Effect of Simulated Microgravity and Shear Stress on Microcin B17 Production by Escherichia coli and on its Excretion into the Medium | Fang A, Pierson DL, Koenig DW, Mishra SK, Demain AL | Appl Environ Microbiol 1997; 63:4090-4092 |
Effect of modeled reduced gravity conditions on bacterial morphology and physiology | Vukanti R, Model MA, Leff LG | BMC Microbiol 2012 Jan 12; 12:4 |
Effects of Simulated Microgravity on the Physiology of Stenotrophomonas maltophilia and Multiomic Analysis | Su X, Guo Y, Fang T, Jiang X, Wang D, Li D, Bai P, Zhang B, Wang J, Liu C | Front Microbiol 2021; 12:701265 |
Effects of low-shear modeled microgravity on a microbial community filtered through a 0.2-µm filter and its potential application in screening for novel microorganisms | | J Biosci Bioeng 2012 Jul; 114(1):73-9 |
Effects of low-shear modeled microgravity on the characterization of recombinant β-D-glucuronidase expressed in Pichia pastoris | Qi F, Dai D, Liu Y, Kaleem I, Li C | Appl Biochem Biotechnol 2011; 163(1):162-7 |
Emergence of two distinct subpopulations from Klebsiella pneumoniae grown in the stimulated microgravity environment | Wang H, Li W, Gu L, Gao, Ni B, Deng H, Yang R, Han Y | Future Microbiol 2017; 12:939-951 |
Escherichia coli biofilms formed under low-shear modeled microgravity in a ground-based system | Lynch SV, Mukundakrishnan K, Benoit MR, Ayyaswamy PS, Matin A | Appl Environ Microbiol 2006; 72:7701-7710 |
Expression of Multiple Stress Response Genes by Escherichia Coli Under Modeled Reduced Gravity | | J Microgravity Science and Technology 2012 Sept 1; 24(4):267-79 |
From Single Cells to Engineered and Explanted Tissues: New Perspectives in Bacterial Infection Biology | | Int Rev Cell Mol Biol 2015; 319:1-44 |
Gramicidin S Production by Bacillus brevis in Simulated Microgravity | Fang A, Pierson DL, Mishra SK, Koenig DW, Demain AL | Curr Microbiol 1997; 34:199-204 |
Growth and Membrane Polarization in Pseudomonas aeruginosa UG2 Grown in Randomized Microgravity in a High Aspect Ratio Vessel | England LS, Gorzelak M, Trevors JT | Biochim Biophys Acta 2003; 1624:76-81 |
Growth of Lactobacillus reuteri DSM17938 Under Two Simulated Microgravity Systems | Senatore G, Mastroleo F, Leys N, Mauriello G | Astrobiology 2020; 20(1):1-14 |
Growth of Staphylococcus aureus Using a Rotary Cell Culture System | | Methods Mol Biol 2021; 2341:79-88 |
High throughput de novo RNA sequencing elucidates novel responses in Penicillium chrysogenum under microgravity | Sathishkumar Y, Krishnaraj C, Rajagopal K, Sen D, Lee YS | Bioprocess Biosyst Eng 2015 Nov 24 |
Human norovirus infection of Caco-2 cells grown as a three-dimensional tissue structure | Straub TM, Bartholomew RA, Valdez CO, Valentine NB, Dohnalkova A, Ozanich RM, Bruckner-Lea CJ, Call DR | J Water Health 2011 Jun; 9(2):225-40 |
Human three-dimensional endometrial epithelial cell model to study host interactions with vaginal bacteria and Neisseria gonorrhoeae | Łaniewski P, Gomez A, Hire G, So M, Herbst-Kralovetz MM | Infect Immun 2017 Jan 4. pii: IAI.01049-16 |
IL-36γ Augments Host Defense and Immune Responses in Human Female Reproductive Tract Epithelial Cells | Winkle SM, Throop AL, Herbst-Kralovetz MM | Front Microbiol, 17 June 2016 |
Impact of Pristine Graphene on Intestinal Microbiota Assessed Using a Bioreactor-Rotary Cell Culture System | Lahiani MH, Gokulan K, Williams K, Khare S | ACS Appl Mater Interfaces 2019; 11(29):25708-25719 |
Impact of simulated microgravity on the normal developmental time line of an animal-bacteria symbiosis | Foster JS, Khodadad CL, Ahrendt SR, Parrish ML | Sci Rep 2013 Feb 26; 3:1340 |
In vitro cell culture infectivity assay for human noroviruses | Straub TM, Honer zu Bentrup K, Orosz-Coghlan P, Dohnalkova A, Mayer BK, Bartholomew RA, Valdez CO, Bruckner-Lea C, Gerba CP, Abbaszadegan M, Nickerson CA | Emerging Infect Dis 2007; 13:396-403 |
Increased biofilm formation ability in Klebsiella pneumoniae after short-term exposure to a simulated microgravity environment | Wang H, Yan Y, Rong D, Wang J, Liu Z, Wang J, Yang R, Han Y | Microbiologyopen 2016 May 16 |
Induction of attachment-independent biofilm formation and repression of Hfq expression by low-fluid-shear culture of Staphylococcus aureus | Castro SL, Nelman-Gonzalez M, Nickerson CA, Ott CM | Appl Environ Microbiol 2011 Sep; 77(18):6368-78 |
Influence of Low-Shear Modeled Microgravity on Heat Resistance, Membrane Fatty Acid Composition, and Heat Stress-Related Gene Expression in Escherichia coli O157 | | Appl Environ Microbiol 2016 Mar 4 |
Invasion of Human Tissue Ex Vivo by Borrelia | Duray P, Yin S, Ito Y, Bezrukov L, Cox C, Cho M, Fitzgerald W | J Infect Dis 2005; 191:1747-1754 |
Involvement of nitric oxide in the mechanism of biochemical alterations induced by simulated microgravity in Microcystis aeruginosa | | Adv Space Res 2012 Mar 1; 49(5):850-8 |
Low-Shear Modeled Microgravity Alters the Salmonella Enterica Serovar Typhimurium Stress Response in an RpoS-independent Manner | Wilson JW, Ott CM, Ramamurthy R, Porwollik S, McClelland M, Pierson DL, Nickerson CA | Appl Environ Microbiol 2002; 68:5408-5416 |
Low-Shear Modeled Microgravity Enhances Salmonella Enterica Resistance to Hydrogen Peroxide Through a Mechanism Involving KatG and KatN | Pacello F, Rotilio G, Battistoni A | Open Microbiol J 2012; 6:53-64 |
Low-Shear Modeled Microgravity: A Global Environmental Regulatory Signal Affecting Bacterial Gene Expression | Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, LeBlanc CL, et al. | J Microbiol Methods 2003; 54:1-11 |
Maintenance of antimicrobial susceptibility of Acinetobacter baumannii in modeled microgravity | | Clin Lab Sci 2010; 23(2):84-8 |
Media Ion Composition Controls Regulatory and Virulence Response of Salmonella in Spaceflight | Wilson JW, Ott CM, Quick L, Davis R, Zu Bentrup KH, Crabbé A, Richter E, Sarker S, Barrila J, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Shah M, Nelman-Gonzalez M, Hing S, Parra M, Dumars P, Norwood K, Bober R, Devich J, Ruggles A, deBaca AC, Narayan S, Benjamin J, Goulart C, Rupert M, Catella L, Schurr MJ, Buchanan K, Morici L, McCracken J, Porter MD, Pierson DL, Smith SM, Mergeay M, Leys N, Stefanyshyn-Piper HM, Gorie D, Nickerson CA | |
Microarray Analysis Identifies Salmonella Genes Belonging to the Low-Shear Modeled Microgravity Regulon | Wilson JW, Ramamurthy R, Porwollik S, McClelland M, Hammond T, Allen P, Ott CM, Pierson DL, Nickerson CA | Proc Natl Acad Sci USA 2002; 99:13807-13812 |
Microbial Responses to Microgravity and Other Low-Shear Environments | Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, Pierson DL | Microbiol Mol Biol Rev 2004; 68:345-361 |
Microbial products alter the expression of membrane-associated mucin and antimicrobial peptides in a three-dimensional human endocervical epithelial cell model | Radtke AL, Quayle AJ, Herbst-Kralovetz MM | Biol Reprod 2012 Dec 6; 87(6):132 |
Microgravity as a Novel Environmental Signal Affecting Microbial Virulence | Nickerson CA, Ott M, Mister SJ, Morrow BJ, Burns-Keliher L, Pierson DL | Infect Immun 2000; 68:3147-3150 |
Microgravity as a biological tool to examine host-pathogen interactions and to guide development of therapeutics and preventatives that target pathogenic bacteria | Higginson EE, Galen JE, Levine MM, Tennant SM | Pathog Dis 2016 Sep 13. pii: ftw095 |
Modeled microgravity cultivation modulates N-acylhomoserine lactone production in Rhodospirillum rubrum S1H independently of cell density | Mastroleo F, Van Houdt R, Atkinson S, Mergeay M, Hendrickx L, Wattiez R, Leys N | Microbiology 2013 Dec; 159(Pt 12):2456-66 |
Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age | Barrila J, Crabbé A, Yang J, Franco K, Nydam SD, Forsyth RJ, Davis RR, Gangaraju S, Ott M, Coyne, CB, Bissell MJ, Nickerson CA | Infection and Immunity 2018; 86(11): e00282-18 |
Mycoplasma genitalium infection activates cellular host defense and inflammation pathways in a 3-dimensional human endocervical epithelial cell model | McGowin CL, Radtke AL, Abraham K, Martin DH, Herbst-Kralovetz M | J Infect Dis 2013 Jun 15; 207(12):1857-68 |
New insights into the bacterial fitness-associated mechanisms revealed by the characterization of large plasmids of an avian pathogenic E. coli | Mellata M, Maddux JT, Nam T, Thomson N, Hauser H, Stevens MP, Mukhopadhyay S, Sarker S, Crabbé A, Nickerson CA, Santander J, Curtiss R 3rd | |
Novel Antibiotic Testing Approaches Reveal Reduced Antibiotic Efficacy Against Shiga Toxin-Producing Escherichia coli O157 Under Simulated Microgravity | | Front Microbiol 2018; 9:3214 |
Novel three-dimensional organoid model for evaluation of the interaction of uropathogenic Escherichia coli with terminally differentiated human urothelial cells | Smith YC, Grande KK, Rasmussen SB, O’Brien AD | Infect Immun 2006; 74:750-757 |
Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions | Barrila J, Radtke AL, Crabbé A, Sarker SF, Herbst-Kralovetz MM, Ott CM, Nickerson CA | Nat Rev Microbiol 2010 Nov; 8(11):791-801 |
Physiological fluid shear alters the virulence potential of invasive multidrug-resistant non-typhoidal Salmonella Typhimurium D23580 | Yang J, Barrila J, Roland KL, Ott CM, Nickerson CA | npj Microgravity 2, Article number: 16021 (2016) |
Relief from Glucose Interference in Microcin B17 Biosynthesis by Growth in a Rotating-Wall Bioreactor | Fang A, Pierson DL, Mishra SK, Demain AL | Lett Appl Microbiol 2000; 31:39-41 |
Response of Pseudomonas aeruginosa PAO1 to low shear modeled microgravity involves AlgU regulation | Crabbé A, Pycke B, Van Houdt R, Monsieurs P, Nickerson C, Leys N, Cornelis P | Environ Microbiol 2010; 12:1545-1564 |
Responses of haloarchaea to simulated microgravity | Dornmayr-Pfaffenhuemer M, Legat A, Schwimbersky K, Fendrihan S, Stan-Lotter H | Astrobiology 2011; 11(3):199-205 |
Role and Regulation of Sigma S in General Resistance Conferred by Low-shear Simulated Microgravity in Escherichia coli | Lynch SV, Brodie EL, Matin A | J Bacteriol 2004; 186:8207-8212 |
Rotating wall vessel exposure alters protein secretion and global gene expression in Staphylococcus aureus | Rosado H, O’Neill AJ, Blake KL, Walther M, Long PF, Hinds J, Taylor PW | Int J Astrobiol 2012 Apr; 11(2):71-81 |
Secondary Metabolism in Simulated Microgravity | | |
Secondary Metabolism in Simulated Microgravity: B-Lactam Production by Streptomyces clavuligerus | Fang A, Pierson DL, Mishra SK, Koenig DW, Demain AL | J Ind Microbiol Biotechnol 1997; 18:22-25 |
Shear Stress Enhances Microcin B17 Production in a Rotating Wall Bioreactor, But Ethanol Does Not | Gao Q, Fang A, Pierson DL, Mishra SK, Demain AL | Appl Microbiol Biotechnol 2001; 56:384-387 |
Simulated microgravity affects ciprofloxacin susceptibility and expression of acrAB-tolC genes in E. coli ATCC25922 | Xu B, Li C, Zheng Y, Si S, Shi Y, Huang Y, Zhang J, Cui Y, Cui Y | Int J Clin Exp Pathol 2015 Jul 1; 8(7):7945-52 |
Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq | Wilson JW, Ott CM, Zu Bentrup KH, Ramamurthy R, Quick L, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Fernandez D, Richter E, Shah WM, Kilcoyne M, Joshi L, Nelman-Gonzalez M, Hing S, Parra M, Dumars P, Norwood K, Bober R, Devich J, Ruggles A, Goulart C, Stodieck L, Stafford P, Catella L, Schurr MJ, Buchanan K, Morici L, McCracken J, Allen P, Baker-Colman C, Hammond T, Vogel J, Nelson R, Pierson DL, Stefanyshyn-Piper HM, Nickerson CA | Proc Natl Acad Sci USA 2007; 104:16299-16304 |
Spaceflight and modeled microgravity effects on microbial growth and virulence | Rosenzweig JA, Abogunde O, Thomas K, Lawal A, Nguyen YU, Sodipe A, Jejelowo O | Appl Microbiol Biotechnol 2010; 85:885-891 |
Studying host-pathogen interactions in 3-D: organotypic models for infectious disease and drug development | Nickerson CA, Richter EG, Ott CM | J Neuroimmune Pharmacol 2007; 2:26-31 |
The Effects of Modeled Microgravity on Growth Kinetics, Antibiotic Susceptibility, Cold Growth, and the Virulence Potential of a Yersinia pestis ymoA-Deficient Mutant and Its Isogenic Parental Strain | Lawal A, Kirtley ML, van Lier CJ, Erova TE, Kozlova EV, Sha J, Chopra AK, Rosenzweig JA | Astrobiology 2013 Sep; 13(9):821-32 |
The International Space Station: an Extreme Environment for Key Host-Microbe Discoveries | Ott CM, Marshburn T, Nickerson CA | Microbe—Volume 11, Number 6, 2016, Pages 253-261 |
The effect of low shear force on the virulence potential of Yersinia pestis: new aspects that space-like growth conditions and the final frontier can teach us about a formidable pathogen | | Front Cell Infect Microbiol 2012 Aug 9; 2:107 |
The influence of spaceflight and simulated microgravity on bacterial motility and chemotaxis | Acres JM, Youngapelian MJ, and Nadeau J | npj Microgravity (2021) 7:7 |
The use of a three-dimensional cell culture model to investigate host-pathogen interactions of Francisella tularensis in human lung epithelial cells | David J, Sayer NM, Sarkar-Tyson M | Microbes Infect 2014 May 4 |
Three-Dimensional Growth of Extravillous Cytotrophoblasts Promotes Differentiation and Invasion | LaMarca HL, Ott CM, Honer zu Bentrup K, LeBlanc CL, Pierson DL, Nelson AB, Scandurro AB, Whitley GSJ, Nickerson CA, Morris CA | Placenta 2005; 26:709-720 |
Three-Dimensional Tissue Assemblies: Novel Models for the Study of Salmonella Enterica Serovar Typhimurium Pathogenesis | Nickerson CA, Goodwin TJ, Terlonge J, Ott CM, Buchanan KL, Uicker WC, Emami K, LeBlanc C, Ramamurthy R, Clarke MS, Vanderburg CR, Hammond T, Pierson DL | Infect Immun 2001; 69:7106-7120 |
Three-dimensional low shear culture of Mycobacterium bovis BCG induces biofilm formation and antimicrobial drug tolerance | Cantillon D, Wroblewska J, Cooper I, Newport MJ, Waddell SJ | npj Biofilms and Microbiomes (2021) 7:12 |
Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns | Barrila J, Yang J, Crabbé A, Sarker SF, Liu Y, Ott CM, Nelman-Gonzalez MA, Clemett S, Nydam SD, Forsyth RJ, Davis RR, Crucian BE, Quiriarte H, Roland KL, Brenneman K, Sams C, Loscher CA, Nickerson CA | npj Microgravity 2017 Feb 28; 3(1):10 |
Three-dimensional organotypic models of human colonic epithelium to study the early stages of enteric salmonellosis | Honer Zu Bentrup K, Ramamurthy R, Ott CM, Emami K, Nelman-Gonzalez M, Wilson JW, Richter EG, Goodwin TJ, Alexander JS, Pierson DL, Pellis N, Buchanan KL, Nickerson CA | Microbes Infect 2006; 8:1813-182 |
Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen | Crabbé A, Schurr MJ, Monsieurs P, Morici L, Schurr J, Wilson JW, Ott CM, Tsaprailis G, Pierson DL, Stefanyshyn-Piper H, Nickerson CA | Appl Environ Microbiol 2011 Feb; 77(4):1221-30 |
Use of the rotating wall vessel technology to study the effect of shear stress on growth behaviour of Pseudomonas aeruginosa PA01 | Crabbé A, De Boever P, Van Houdt R, Moors H, Mergeay M, Cornelis P | Environ Microbiol 2008; 10:2098-2110 |
