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Research Publications / Osteo

3D sample preparation for orthopaedic tissue engineering bioreactors.
Cartmell SH, Rathbone S, Jones G, Hidalgo-Bastida LA
Textbook chapter in 3D Cell Culture: Methods and Protocols
A mesoscale study of the degradation of bone structural properties in modeled microgravity conditions.
Cosmi F, Steimberg N, Mazzoleni G
J Mech Behav Biomed Mater. 2015 Jan 12;44C:61-70
An ex vivo model for chondrogenesis and osteogenesis
Pound JC, Green DW, Roach HI, Mann S, Oreffo RO
Biomaterials 28:2839-2849, 2007
Analysis of the attachment and differentiation of three-dimensional rotary wall vessel cultured human preosteoblasts on dental implant surfaces. Ko YJ, Zaharias RS, Seabold DA, Lafoon JE, Schneider GB Int J Oral Maxillofac Implants 25:722-728, 2010 http://www.ncbi.nlm.nih.gov/pubmed/20166753 Establishment of three-dimensional tissue-engineered bone constructs under microgravity-simulating conditions. Jin F, Zhang Y, Xuan K, He D, Deng T, Tang L, Lu W, Duan Y Artif Organs 34:118-125, 2009 http://www.ncbi.nlm.nih.gov/pubmed/20166753 NASA approved rotary bioreactor enhances proliferation and osteogenesis of human periodontal ligament stem cells. Li S, Niu Z, Qian H, Xuan D, Hou R, Ni L Stem Cells Dev. 18:1273-82, 2009 http://www.ncbi.nlm.nih.gov/pubmed/20166753 Global transcriptome analysis in mouse calvarial osteoblasts highlights sets of genes regulated by modeled microgravity and identifies a "mechanoresponsive osteoblast gene signature.
Capulli M, Rufo A, Teti A, Rucci N
J. Cell Biochem. 107:240-52, 2009
Bioreactor systems for bone tissue engineering.
Rauh J, Milan F, Gunther KP, Stiehler M
Tissue Eng Part B Rev. 2011 Aug;17(4):263-80
Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds, and rotating bioreactors
Marolt D, Augst A, Freed LE, Vepari C, Fajardo R, Patel N, Gray M, Farley M, Kaplan D, Vunjak-Novakovic G
Biomaterials 27:6138-6149, 2006
Bone tissue engineering bioreactors: dynamic culture and the influence of shear stress.
Yeatts AB, Fisher JP
Bone; 48(2):171-81, 2011
Cell-Nanofiber based cartilage tissue engineering using improved cell seeding, growth factor and bioreactor technologies.
Li WJ, Jiang YJ, Tuan RS
Tissue Engineering: Part A. 14:639-48, 2008
Cementum protein 1 (CEMP1) induces differentiation by human periodontal ligament cells under three-dimensional culture conditions.
Hoz L, Romo E, Zeichner-David M, Sanz M, Nunez J, Gaitan L, Mercado G, Arzate H
Cell Biol Int. 2012 Feb 1;36(2):129-36
Combined Effects of Simulated Microgravity and Radiation Exposure on Osteoclast Cell Fusion.
Shanmugarajan S, Zhang Y, Moreno-Villanueva M, Clanton R, Rohde LH, Ramesh GT, Sibonga JD, Wu H
Int J Mol Sci. 2017 Nov 18;18(11)
Conditioned media from microvascular endothelial cells cultured in simulated microgravity inhibit osteoblast activity.
Cazzaniga A, Castiglioni S, Maier JA
Biomed Res Int. 2014;2014:857934
Could the effect of modeled microgravity on osteogenic differentiation of human mesenchymal stem cells be reversed by regulation of signaling pathways?
Zheng Q, Huang G, Xu Y, Guo C, Xi Y, Pan Z, Wang J
Biol Chem 388:755-763, 2007
Destrin deletion enhances the bone loss in hindlimb suspended mice.
Shuang F, Sun Y, Yang HH, Shao YC, Li H, Hu W, Zhong J, Zou HX
Eur J Appl Physiol. 2013 Feb;113(2):403-10
Differentiation of human mesenchymal stem cell spheroids under microgravity conditions
Cerwinka WH, Sharp SM, Boyan BD, Zhau HE, Chung LWK, Yates C
Cell Regeneration 2012, 1:2
Effect of dynamic three-dimensional culture on osteogenic potential of human periodontal ligament-derived mesenchymal stem cells entrapped in alginate microbeads.
Vecchiatini R, Penolazzi L, Lambertini E, Angelozzi M, Morganti C, Mazzitelli S, Trombelli L, Nastruzzi C, Piva R
J Periodontal Res. 2014 Sep 23
Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds and bioreactors.
August A, Marolt D, Freed LE, Vepari C, Meinel L, Farley M, Fajardo R, Patel M, Gray M, Kaplan DL, Vunjak-Novakovic G
J R Soc Interface. 2008 Aug 6;5(25):929-39
Encapsulation and osteoinduction of human periodontal ligament fibroblasts in chitosan-hydroxyapatite microspheres
Inac B, Eser Elcin A, Koc A, Balos K, Parlar A, Murat Elcin Y
Biomed Mater Res A 82:917-926, 2007
Engineered bone tissue associated with vascularization utilizing a rotating wall vessel bioreactor.
Nishi M, Matsumoto R, Dong J, Uemura T
J Biomed Mater Res A. 2012 Aug 3
Enhanced cell ingrowth and proliferation through three dimensional nano composite scaffolds with controlled pore structures.
Lee KW, Wang S, Dadsetan M, Yaszemski MJ, Lu L
Biomacromolecules. 11:682-9, 2010
Enhancement of matrix production and cell proliferation in human annulus cells under bioreactor culture.
Yang X, Wang D, Hao J, Gong M, Arlet V, Balian G, Shen FH, Li XJ
Tissue Eng Part A; 17(11-12):1595-603, June 2011
Establishment of a 3D-dynamic osteoblasts-osteoclasts co-culture model to simulate the jawbone microenvironment in vitro.
Penolazzi L, Lolli A, Sardelli L, Angelozzi M, Lambertini E, Trombelli L, Ciarpella F, RenataVecchiatini, Piva R
Life Sci. 2016 Mar 22
Fabrication and detection of tissue-engineered bones with bio-derived scaffolds in a rotating bioreactor
Song K, Yang Z, Liu T, Zhi W, Li X, Deng L, Cui Z, Ma X
Biotechnol. Appl. Biochem. 45(pt 2):65-74, 2006
Fabrication, characterization, and in vitro evaluation of poly(lactic acid glycolic acid)/nano-hydroxyapatite composite microsphere-based scaffolds for bone tissue engineering in rotating bioreactors.
Lv Q, Nair L, Laurencin CT
J Biomed Mater Res A 91:679-691, 2009
Freeze-dried human serum albumin improves the adherence and proliferation of mesenchymal stem cells on mineralized human bone allografts.
Weszl M, Skaliczki G, Cselenyiak A, Kiss L, Major T, Schandl K, Bognar E, Stadler G, Peterbauer A, Csongor L
J Orthop Res. 2012 Mar;30(3):489-96
Genome-wide analysis and prediction of functional long noncoding RNAs in osteoblast differentiation under simulated microgravity.
Hu Z, Wang H, Wang Y, Zhou H, Shi F, Zhao J, Zhang S, Cao X
Mol Med Rep. 2017 Dec;16(6):8180-8188
In vitro three-dimensional development of mouse molar tooth germs in a rotary cell culture system.
Sun L, Yang C, Ge Y, Yu M, Chen G, Guo W, Tian W
Int J Paediatr Dent. 2013 Jul 19
Microarray profile of gene expression during osteoclast differentiation in modeled microgravity.
Sambandam Y, Blanchard JJ, Daughtridge G, Kolb RJ, Shanmugarajan S, Pandruvada SN, Bateman TA, Reddy SV
J Cell Biochem. 2010 Dec 1;111(5):1179-87
Microgravity Induction of TRAIL Expression in Preosteoclast Cells Enhances Osteoclast Differentiation.
Sambandam Y, Baird KL, Stroebel M, Kowal E, Balasubramanian S, Reddy SV
Sci Rep. 2016 May 4;6:25143
Microgravity control of autophagy modulates osteoclastogenesis.
Sambandam Y, Townsend MT, Pierce JJ, Lipman CM, Haque A, Bateman TA, Reddy SV
Bone. 2014 Jan 23
Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANK/OPG ratio
Rucci N, Rufo A, Alamanou M, Teti A
J. Cell. Biochem. 100:464-473, 2007
Nano-ceramic composite scaffolds for bioreactor-based bone engineering.
Lv Q, Deng M, Ulery BD, Nair LS, Laurencin CT
Clin Orthop Relat Res. 2013 Aug;471(8):2422-33
Numerical simulation of fluid field and in vitro three-dimensional fabrication of tissue-engineered bones in a rotating bioreactor and in vivo implantation for repairing segmental bone defects.
Song K, Wang H, Zhang B, Lim M, Liu Y, Liu T
Cell Stress Chaperones. 2013 Mar;18(2):193-201
Osteoblast and Osteoclast Differentiation in Modeled Microgravity.
Saxena R, McDonald J
Ann NY Acad Sci. 1116:494-498, 2007
Osteogenic differentiation of encapsulated rat mesenchymal stem cells inside a rotating microgravity bioreactor: in vitro and in vivo evaluation.
Koç Demir A, Elçin AE, Elçin YM
Cytotechnology. 2018;70(5):1375-1388
Proteasome inhibition suppress microgravity elevated RANK signaling during osteoclast differentiation.
Ethiraj P, Ottinger AM, Singh T, Singh A, Haire KM, Reddy SV
Cytokine. 2019; 125:154821
RCCS enhances EOE cell proliferation and their differentiation into ameloblasts.
Li P, Zhang Y, Wang YM, Duan CM, Hao T, Wu BL, Wang CY
Mol Biol Rep. 2012 Jan;39(1):309-17
Repair of large osteochondral defects with allogenic cartilaginous aggregates formed from bone marrow-derived cells using RWV bioreactor.
Yoshioka T, Mishima H, Ohyabu Y, Sakai S, Akaogi H, Ishii T, Kojima H, Tanaka J, Ochiai N, Uemura T
J Orthop Res 25:1291-1298, 2007
RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment.
Louis F, Bouleftour, Rattner A, Linossier MT, Vico L, Guignandon A
NPJ Microgravity. 2017 Jan 25;3:7
Strategies to Promote Chondrogenesis and Osteogenesis from Human Bone Marrow Cells and Articular Chondrocytes Encapsulated in Polysaccharide Templates
Pound JC, Green DW, Chaudhuri JB, Mann S, Roach HI, Oreffo RO
Tissue Eng 12:2789-2799, 2006
The Effect of OSM on MC3T3-E1 Osteoblastic Cells in Simulated Microgravity with Radiation.
Goyden Goyden J, Tawara K, Hedeen D, Willey JS, Thom Oxford J, Jorcyk CL
PLoS One. 2015 Jun 1;10(6)
The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro.
Spatz JM, Wein MN, Gooi JH, Qu Y, Garr JL, Liu S, Barry KJ, Uda Y, Lai F, Dedic C, Balcells-Camps M, Kronenberg HM, Babij P, Pajevic PD
J Biol Chem. 2015 Jul 3;290(27):16744-58
The effect of Smads signal pathway on the osteogenesis of human periodontal ligament stem cells in simulated microgravity.
Li Y, Li S, Niu ZY, Bao B, Shi X
Shanghai Kou Qiang Yi Xue. 2012 Jun;21(3):246-50
The effect of simulated microgravity on human mesenchymal stem cells cultured in an osteogenic differentiation system: a bioinformatics study.
Sheyn D, Pelled G, Netanely D, Domany E, Gazit D
Tissue Eng Part A. 16(11):3403-12, 2010
The effect of simulated microgravity on osteoblasts is independent of the induction of apoptosis.
Bucaro MA, Zahm AM, Risbud MV, Avyaswamy PS, Mukundakrishnan K, Steinbeck MJ, Shapiro IM, Adams CS
J Cell Biochem 102:483-495, 2007
The effects of simulated microgravity on intervertebral disc degeneration.
Jin L, Feng G, Reames DL, Shimer AL, Shen FH, Li X
Spine J. 2013 Mar;13(3):235-42
Three-dimensional expansion: in suspension culture of SD rat’s osteoblasts in a rotating wall vessel bioreactor.
Song KD, Liu TQ, Li XQ, Cui ZF, Sun XY, Ma XH
Biomed Environ Sci 20:91-98, 2007
Three-dimensional simulated microgravity culture improves the proliferation and odontogenic differentiation of dental pulp stem cell in PLGA scaffolds implanted in mice.
Li Y, He L, Pan S, Zhang L, Zhang W, Yi H, Niu Y
Mol Med Rep. 2017 Feb;15(2):873-878
Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats.
Sun Y, Shuang F, Chen DM, Zhou RB
Osteoporos Int. 2013 Mar;24(3):969-78
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