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Research Publications /
Spaceflight/Microgravity Physiology

A Potential Cause for Kidney Stone Formation During Space Flights: Enhanced Growth of Nanobacteria in Microgravity
Ciftcioglu N, Haddad RS, Golden DC, Morrison DR, McKay DS
Kidney Int. 67: 483-491, 2005
A Simulated Microgravity Environment Causes a Sustained Defect in Epithelial Barrier Function
Alvarez R, Stork CA, Sayoc-Becerra A, Marchelletta RR, Prisk GK, McCole DF
Sci Rep 2019, 9(1): 17531
A Study of Alterations in DNA Epigenetic Modifications (5mC and 5hmC) and Gene Expression Influenced by Simulated Microgravity in Human Lymphoblastoid Cells
Chowdhury B, Seetharam A, Wang Z, Liu Y, Lossie AC, Thimmapuram J, Irudayaraj J
PLoS One. 2016 Jan 28;11(1):e0147514
Altered mitochondrial dynamics under microgravity conditions: Impact on neurodegenerative diseases
Sun T, Xu Y, Zhang Y, Li X, Ma J
Front Aging Neurosci. 2019 Sep;11:225
Cardiovascular responses of mesenchymal stem cells to microgravity environments
Chen H, Zhao Y, Zhao W, Li X
J Cardiovasc Transl Res. 2019 Apr;12(2):181-190
Combined Effects of Simulated Microgravity and Radiation Exposure on Osteoclast Cell Fusion
Shanmugarajan S, Zhang Y, Moreno-Villanueva M, Clanton R, Rohde LH, Ramesh GT, Sibonga JD, Wu H
Int J Mol Sci. 2017 Nov 18;18(11). pii: E2443
Conservation of the Low-shear Modeled Microgravity Response in Enterobacteriaceae and Analysis of the trp Genes in this Response
Soni A, O'Sullivan L, Quick LN, Ott C, Nickerson CA, Wilson JW
Open Microbiol J. 2014 Jun 13;8:51-8
Culturing Lymphocytes in Simulated Microgravity using a Rotary Cell Culture System
Marieke de Korte, Armand Keating, Chen Wang
PMID: 36094288
Effect Of Microgravity On Aromatase Expression In Sertoli Cells
Cirelli E, De Domenico E, Botti F, Massoud R, Geremia R, Grimaldi P
Sci Rep. 2017 Jun 14;7(1):3469
Effect of Culture in Simulated Microgravity on the Development of Mouse Embryonic Testes
Nowacki D, Klinger FG, Mazur G, Felici MD
Adv Clin Exp Med. 2015 Sep-Oct;24(5):769-74
Effect of Low Shear Modeled Microgravity on the Development of Cancer Cell Line and Immune Cells Interaction
Ramasamy C, Ma Y, Patel K, Mehta J
Front Oncol. 2021 Oct;11:737204
Effect of Simulated Microgravity on the Production of IL-12 by PBMC’s
Bakos A, Varkonyi A, Minarovits J, Batkai L
J Gravit Physiol. 9: 293-294, 2002
Effect of microgravity on the mesenchymal stem cell characteristics of limbal fibroblasts
Pao SI, Chien KH, Lin HT, Tai MC, Chen JT, Liang CM
J Chin Med Assoc. 2017 May 18
Effects of simulated microgravity on human brain nervous tissue
Wang X, Du J, Wang D, Zeng F, Wei Y, Wang F, Feng C, Li N, Dai R, Deng Y, Quan Z, Qing H
Neurosci Lett. 2016 Aug 3;627:199-204
Epigenetic Regulation in a Simulated Microgravity Environment: Focus on Histone Modifications
He J, Zhang Q, Zhou J, Liang H
Front Genet. 2020 Mar;11:244
Epigenetic changes induced by simulated microgravity in the human nervous system
Kim SJ, Park SH, Lee HS, Jung H
Neurosci Lett. 2020 Oct;735:135204
Epigenetic modifications in simulated microgravity: Insight into the role of mechanobiology in cancer
Li Y, Chang C, Zheng X, Sun H
Cancer Lett. 2020 May 10;477:8-20
Evaluating the effects of microgravity on mesenchymal stem cell differentiation using a rotary cell culture system
Brown JD, Lim R, Hu M, Tuan RS
Stem Cells Transl Med. 2018 Apr;7(4):340-350
Experimental study on effect of simulated microgravity on structural chromosome instability of human peripheral blood lymphocytes
Wei L, Liu C, Kang L, Liu Y, Shi S, Wu Q, Li Y
PLoS One. 2014 Jun 25;9(6):e100595
Expression of Multiple Stress Response Genes by Escherichia Coli Under Modeled Reduced Gravity
Vukanti R, Leff LG
J Microgravity Science and Technology. 2012 Sept 1;24(4):267-79
Gene expression alterations in activated human T-cells induced by modeled microgravity
Ward NE, Pellis NR, Risin SA, Risin D
J. Cell. Biochem. 2006
Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene Networks
Prasanna Vidyasekar, Pavithra Shyamsunder, Rajpranap Arun, Rajalakshmi Santhakumar, Nand Kishore Kapadia, Ravi Kumar, Rama Shanker Verma
PLoS One. 2015; 10(8): e0135958
Genome-wide analysis and prediction of functional long noncoding RNAs in osteoblast differentiation under simulated microgravity
Hu Z, Wang H, Wang Y, Zhou H, Shi F, Zhao J, Zhang S, Cao X
Mol Med Rep. 2017 Dec;16(6):8180-8188
Growing tissues in real and simulated microgravity - new methods for tissue engineering
Grimm D, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, Ulbrich C, Magnusson NE, Infanger M, Bauer J
Tissue Eng Part B Rev. 2014 Apr 4
Impact of Modeled Microgravity on Migration, Differentiation, and Cell Cycle Control of Primitive Human Hematopoietic Progenitor Cells
Plett PA, Abonour R, Frankovitz SM, Orschell CM
Experimental Hematology 32: 773-781, 2004
Impact of microgravity on myostatin expression and cell death in human skeletal muscle cell lines
Sharma A, Singh M, Sharma S, Pandey S, Mittal A
J Appl Physiol. 2019 Oct 1;127(4):984-994
Impact of modeled microgravity on microvascular endothelial cells
Cotrupi S, Ranzani D, Maier JA
Biochem Biophys Acta 1746(2):163-168, 2005
Impact of simulated microgravity on the normal developmental time line of an animal-bacteria symbiosis
Foster JS, Khodadad CL, Ahrendt SR, Parrish ML
Sci Rep. 2013 Feb 26;3:1340
Increased biofilm formation ability in Klebsiella pneumoniae after short-term exposure to a simulated microgravity environment
Wang H, Yan Y, Rong D, Wang J, Wang H, Liu Z, Wang J, Yang R, Han Y
Microbiologyopen. 2016 May 16
Inflammation is involved in response of gastric mucosal epithelial cells under simulated microgravity by integrated transcriptomic analysis
Chai S, Guo S, Yang J, Lu S, Yuan Y, Li H, Sun P, Zhang T, Xu B, Sun H, Si S, Zhou J, Yang J, Yang H, Li Z, Cui Y
Am J Transl Res 2021;13(8):9195-9207
Low-Shear Modeled Microgravity Alters the Salmonella Enterica Serovar Typhimurium Stress Response in an RpoS-independent Manner
Wilson JW, Ott CM, Ramamurthy R, Porwollik S, McClelland M, Pierson DL, Nickerson CA
Applied and Environmental Microbiology 68:5408-5416, 2002
Low-Shear Modeled Microgravity: A Global Environmental Regulatory Signal Affecting Bacterial Gene Expression
Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, LeBlanc CL
Journal of Microbiological Methods 54:1-11, 2003
Mechanosensitive responses of cardiac cells to simulated microgravity: Role of calcium channels
Huang C, Kuo IY, Jao HC, Lee CH, Wang YC
J Physiol. 2020 Feb 15;598(4):677-688
Microarray Analysis Identifies Salmonella Genes Belonging to the Low-Shear Modeled Microgravity Regulon
Wilson JW, Ramamurthy R, Porwollik S, McClelland M, Hammond T, Allen P, Ott CM, Pierson DL, Nickerson CA
Proc. Natl. Acad. Sci. USA 99: 13807-13812, 2002
Microgravity Induction of TRAIL Expression in Preosteoclast Cells Enhances Osteoclast Differentiation
Sambandam Y, Baird KL, Stroebel M, Kowal E, Balasubramanian S, Reddy SV
Sci Rep. 2016 May 4;6:25143
Microgravity as a biological tool to examine host-pathogen interactions and to guide development of therapeutics and preventatives that target pathogenic bacteria
Higginson EE, Galen JE, Levine MM, Tennant SM
Pathog Dis. 2016 Sep 13
Microgravity control of autophagy modulates osteoclastogenesis
Sambandam Y, Townsend MT, Pierce JJ, Lipman CM, Haque A, Bateman TA, Reddy SV
Bone. 2014 Jan 23
Microgravity enhances the invasive potential of human lung adenocarcinoma cells by promoting EMT
Wang H, Zhang J, Xie Y, Zhang H, He X
J Cell Biochem. 2018 May;119(5):4107-4115
Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection
Feger BJ, Thompson JW, Dubois LG, Kommaddi RP, Foster MW, Mishra R, Shenoy SK, Shibata Y, Kidane YH, Moseley MA, Carnell LS, Bowles DE
Sci Rep. 2016 Sep 27;6:34091
Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis
Wang S, Yin Z, Zhao B, Qi Y, Liu J, Rahimi SA, Lee LY, Li S
Stem Cell Res. 2017 Dec;25:157-165
Microgravity simulation affects bacterial biofilm formation by increasing production of extracellular polysaccharides
Peng T, Guo S, Li H, Cui Y
Astrobiology 2020;20(3):353-361
Microgravity-induced changes in the differentiation potential of mesenchymal stem cells
Park JS, Shim MS, Lee YH, Kim H, Lee JE
Int J Stem Cells. 2021;14(3):313-322
Mitochondrial Unfolded Protein Response to Microgravity Stress in Nematode Caenorhabditis elegans
Liu P, Li D, Li W, Wang D
Scientific Rep 2019; 9:16474
Mitophagy contributes to endothelial adaptation to simulated microgravity
Locatelli L, Cazzaniga A, De Palma C, Castiglioni S, Maier JAM
FASEB J 2020; 34(1): 1833-1845
Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANK/OPG ratio
Rucci N, Rufo A, Alamanou M, Teti A
J. Cell. Biochem. 100: 464-473, 2007
Multiple Interleukin-2 Signaling Pathways Differentially Regulated by Microgravity
Licato LL, Grimm EA
Immunopharmacology 44: 273-9, 1999
Proliferation of Human Hematopoietic Bone Marrow Cells in Simulated Microgravity
Plett PA, Frankovitz SM, Abonour R, Orschell-Traycoff CM
In Vitro Cell Dev Biol Anim 37: 73-78, 2001
Regulation of the Response of Caenorhabditis elegans to Simulated Microgravity by p38 Mitogen-Activated Protein Kinase Signaling
Li W, Wang D, Wang D
Sci Rep. 2018 Jan 16;8(1):857
Response of Pseudomonas aeruginosa PAO1 to low shear modeled microgravity involves AlgU regulation
Crabbe A, Pycke B, Van Houdt R, Monsieurs P, Nickerson C, Leys N, Cornelis P
Environ Microbiol 12:1545-1564, 2010
RhoGTPase stimulation is associated with strontium chloride treatment to counter simulated microgravity-induced changes in multipotent cell commitment
Louis F, Bouleftour, Rattner A, Linossier MT, Vico L, Guignandon A
NPJ Microgravity. 2017 Jan 25;3:7
Rotating wall vessel exposure alters protein secretion and global gene expression in Staphylococcus aureus
Rosado H, O’Neill AJ, Blake KL, Walther M, Long PF, Hinds J, Taylor PW
International Journal of Astrobiology. 2012 Apr;11(2):71-81
Secondary Metabolism in Simulated Microgravity
Demain AL and Fang A
Chem Rec 1: 333-346, 2001
Simulated Microgravity Alters T Cell Immune Function
Shubhashree MN, Reddy SD, Prabhakar B, Singh KP
Life Sci Space Res. 2017 Sep;14:1-9
Simulated Microgravity Disrupts Cytoskeleton Organization and Increases Apoptosis of Rat Neural Crest Stem Cells Via Upregulating CXCR4 Expression and RhoA-ROCK1-p38 MAPK-p53 Signaling
Lin SC, Gou GH, Hsia CW, Ho CW, Huang KL, Wu YF, Lee SY, Chen YH
Stem Cells Dev. 2016 Jul 6
Simulated Microgravity Impairs Respiratory Burst Activity in Human Promyelocytic Cells
Hughes JH and Long JP
In Vitro Cell Dev Biol Anim 37: 209-215, 2001
Simulated Microgravity Using a Rotary Culture System Compromises the In Vitro Development of Mouse Preantral Follicles
Zhang S, Zheng D, Wu Y, Lin W, Chen Z, Meng L, Liu J, Zhou Y
PLoS One. 2016 Mar 10;11(3):e0151062
Simulated microgravity affects bone marrow mesenchymal stem cell behavior and function
Yu X, Li H, Zhao P, Xu H, Yang W
Stem Cells Dev. 2019 Dec 1;28(23):1574-1584
Simulated microgravity causes alterations in the global proteome and secretome profile of human osteoblasts
Bhattacharya R, Gupta D, Samanta S, Sharma A, Roy S
PLoS One. 2018 Jul 17;13(7):e0200537
Simulated microgravity decreases DNA repair capacity and induces DNA damage in human lymphocytes
Kumari R, Singh KP, Dumond JW Jr
J. Cell Biochem.107:723-31, 2009
Simulated microgravity enhances stem cell-mediated cartilage regeneration by influencing Wnt/β-catenin signaling
Liu S, Peng Z, Li Z, Sun Y
Stem Cells Transl Med. 2020 Feb;9(2):186-195
Simulated microgravity impairs cardiac autonomic neurogenesis from neural crest cells
Hatzistergos KE, Jiang Z, Valasaki K, Takeuchi LM, Balkan W, Atluri P, Saur D, Seidler B, Tsinoremas N, DiFede D, Hare JM
Stem Cells Dev. 2018 Jan 16
Simulated microgravity increases heavy ion radiation-induced apoptosis in human B lymphoblasts
Dang B, Yang Y, Zhang E, Li W, Mi X, Meng Y, Yan S, Wang Z, Wei W, Shao C, Xing R, Lin C
Life Sci. 2013 Dec 21
Simulated microgravity modulates intracellular signaling pathways in cancer stem cells
Chandra R, Bajpai VK, Lim JH, Sharma A, Lee KG
Int J Mol Sci. 2020 Jun 11;21(12):4171
Simulated microgravity-mediated enhancement of proteome stability and stress resilience in Saccharomyces cerevisiae
Singh RP, Santhakumar PR, Sahoo SK, Ali M, Das P, Banerjee S, Verma RS
NPJ Microgravity 2021;7:1
Simulated microgravity-mediated reversion of murine lymphoma immune evasion
Bradley JH, Barwick S, Horn GQ, Ullrich E, Best B, Arnold JP, Gregg RK
Sci Rep. 2019; 9(1):14623
Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq
Wilson JW, Ott CM, Zu Bentrup KH, Ramamurthy R, Quick L, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Fernandez D, Richter E, Shah WM, Kilcoyne M, Joshi L, Nelman-Gonzalez M, Hing S, Parra M, Dumars P, Norwood K, Bober R, Devich J, Ruggles A, Goulart C, Rupert M, Stodieck L, Stafford P, Catella L, Schurr MJ, Buchanan K, Morici L, McCracken J, Allen P, Baker-Colman C, Hammond T, Vogel J, Nelson R, Pierson DL, Stefanyshyn-Piper HM, Nickerson CA
Proc Natl Acad Sci USA 104: 16299-16304, 2007
Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early t-cell activation
Martinez EM, Yoshida MC, Candelario TT, Hughes-Fulford M
Am J Physiol Regul Integr Comp Physiol. 2015
Spaceflight and simulated microgravity effects on microbial growth and virulence
Rosenzweig JA, Abogunde O, Thomas K, Lawal A, Nguyen YU, Sodipe A, Jejelowo O
Appl Microbiol Biotechnol 85:885-891, 2010
Study of Rotary Cell Culture System-Induced Microgravity Effects on Cancer Biomarkers
Ragini Singh, Rana P Singh
Methods Mol Biol 2022:2413:77-96
T cell resistance to activation by dendritic cells requires long-term culture in simulated microgravity
Bradley JH, Stein R, Randolph B, Molina E, Arnold JP, Gregg RK
Life Sci Space Res (Amst). 2017 Nov;15:55-61
The Effect of OSM on MC3T3-E1 Osteoblastic Cells in Simulated Microgravity with Radiation
Goyden J, Tawara K, Hedeen D, Willey JS, Thom Oxford J, Jorcyk CL
PLoS One. 2015 Jun 1;10(6):e0127230
The International Space Station: an Extreme Environment for Key Host-Microbe Discoveries
C. Mark Ott, Thomas Marshburn, Cheryl A. Nickerson
Microbe—Volume 11, Number 6, 2016, Pages 253-261
The Role of Parathyroid Hormone-Related Protein (PTHrP) in Osteoblast Response to Microgravity: Mechanistic Implications for Osteoporosis Development
Camirand A, Goltzman D, Gupta A, Kaouass M, Panda D, Karaplis A
PLoS One. 2016 Jul 27;11(7):e0160034
The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro
Spatz JM, Wein MN, Gooi JH, Qu Y, Garr JL, Liu S, Barry KJ, Uda Y, Lai F, Dedic C, Balcells-Camps M, Kronenberg HM, Babij P, Pajevic PD
J Biol Chem. 2015 Jul 3;290(27):16744-58
The effect of modeled microgravity on angiogenesis and endothelial cell function in tissue engineering
Mohan R, Katyal S, Pant AB, Gupta S
NPJ Microgravity. 2021 Jun 30;7:27
The effect of modeled microgravity on glial cell activity and its implications for the nervous system
Huang H, Wang P, Zhang X, Li Y, Chen M
Glia. 2020 Jul;68(7):1355-1365
The effects of simulated microgravity on intervertebral disc degeneration
Jin L, Feng G, Reames DL, Shimer AL, Shen FH, Li X
Spine J. 2013 Mar;13(3):235-42
The influence of simulated microgravity on neural stem cell proliferation and differentiation
Jiang W, Xu Y, Wang X, Li S
Neuroreport. 2019 Aug 7;30(12):879-886
The role of oxidative stress in cellular changes induced by simulated microgravity
Patel MR, Shah J, Mehta C, Gupta D
Redox Biol. 2021 Jan;38:101810
Transfection of the IHH gene into rabbit BMSCs in a simulated microgravity environment promotes chondrogenic differentiation and inhibits cartilage aging
Liu PC, Liu K, Liu JF, Xia K, Chen LY, Wu X
Oncotarget. 2016 Sep 6;7(39):62873-62885
Treatment of hydrogen molecule abates oxidative stress and alleviates bone loss induced by modeled microgravity in rats
Sun Y, Shuang F, Chen DM, Zhou RB
Osteoporos Int. 2013 Mar;24(3):969-78
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