The Rotary Cell Culture System bioreactor consists of a rotating culture vessel with a co-axial oxygenator in the center. When the vessel is filled with culture media and rotated, the fluid with the vessel rotates as a solid body about the horizontal axis. The oxygenator rotates concurrently with outer wall of the vessel. These conditions produce laminar flow and minimal shear force inside the culture vessel. The cells are maintained in suspension by the resolution of the centrifugal, gravitational and Coriolis forces, so that cells placed in the RCCS bioreactor experience minimal mechanical stresses and are thus able to assemble into tissue-like aggregates. Gas transfer occurs by diffusion through the silicone oxygenator, thereby avoiding bubble formation and consequent turbulence.For a more detailed explanation of how the Rotary Cell Culture System works and it's key features, view our Technology page.  Also, if you would like to view publications on this topic, we've listed several titles for the Fluid Mechanical Principles of the RCCS in our Bibliography.

Our bioreactor systems are connected to a power supply outside of the incubator via a ribbon cable. This cable is flat and is able to run out of the seal of any stadard incubator door without disturbing the environment inside the incubator.