Synthecon: 3D Culture Systems for 3D World!

Researchers have long used the Rotary Cell Culture System (RCCS) in novel discovery of cell/viral interactions including lung tissue engineering. 

Please review relevant publications below. Also, visit our Gallery for Imaging of 3D Tissue Models.

3D tissue-like assemblies: A novel approach to investigate virus-cell interactions.
Goodwin TJ, McCarthy M, Cohrs RJ, Kaufer BB. Methods. 2015 May 15. pii: S1046-2023(15)00203-0. doi: 10.1016/j.ymeth.2015.05.010. [Abstract] [Full Text]

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling.
Wilkinson DC, Alva-Ornelas JA, Sucre JM, Vijayaraj P, Durra A, Richardson W, Jonas SJ, Paul MK, Karumbayaram S, Dunn B, Gomperts BN. Stem Cells Transl Med. 2017  6: 622-633. [Full Text]

Recellularization of decellularized lung scaffolds is enhanced by dynamic suspension culture.
Crabbé A1, Liu Y1, Sarker SF1, Bonenfant NR2, Barrila J1, Borg ZD2, Lee JJ3, Weiss DJ2, Nickerson CA4.PLoS One. 2015 May 11;10(5):e0126846. doi: 10.1371/journal.pone.0126846. eCollection 2015. [Abstract[Full Text]

Influence of acellular natural lung matrix on murine embryonic stem cell differentiation and tissue formation.
Cortiella J, Niles J, Cantu A, Brettler A, Pham A, Vargas G, Winston S, Wang J, Walls S, Nichols JE.  Tissue Eng Part A. 16(8):2565-80, 2010 [Abstract]

Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lungepithelial model and the influence of fetal bovine serum.
Crabbé A1,2, Liu Y2, Matthijs N1, Rigole P1, De La Fuente-Nùñez C3, Davis R2, Ledesma MA2, Sarker S2, Van Houdt R4, Hancock RE3, Coenye T1, Nickerson CA2,5.Sci Rep. 2017 Mar 3;7:43321. doi: 10.1038/srep43321. [Full Text] [Full Text PDF]

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