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Research Publications / Cancer

Effect of simulated microgravity on metabolism of HGC‑27 gastric cancer cells.  ZHENG‑YANG CHEN1, NAN JIANG1,2, S Guo, B‑B Li, J‑Q Yang,S‑B Chai, H‑F Yan, P‑M Sun, T Zhang, H‑W Sun, H‑M Yang, J‑L Zhou and Y Cui.
ONCOLOGY LETT 19: 3439-3450, 2020 [Full Text]

Simulated microgravity-mediated reversion of murine lymphoma immune evasion. Bradley JH, Barwick S, Horn GQ Ullrich E, Best B, Arnold JP, Gregg RK.  Sci Rep. 2019; 9(1):14623. [Full Text]

Simulated microgravity increases polyploid giant cancer cells and nuclear localization of YAP. Arun RP, Sivanesan D, Patra B, Varadaraj S, Verma RS. Sci Rep. 2019; 9(1):10684.  [Full Text]

Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of
osteoinhibition.  McNeill EP,  Reese RW,  Tondon A, Clough BH, Pan S, Froese J, Palmer D, Krause U, Loeb DM, Kaunas R and Gregory CA. Cell Death and Disease  2018; 9:1161 [Abstract]

Modeling Multiple Myeloma-Bone Marrow interactions and response to drugs in a 3D surrogate microenvironment.
Belloni D1, Heltai S, Ponzoni M, Villa A, Vergani B, Pecciarini L, Marcatti M, Girlanda S, Tonon G, Ciceri F, Caligaris-Cappio F, Ferrarini M, Ferrero E. Haematologica. 2018 Jan 11. pii: haematol.2017.167486. doi: 10.3324/haematol.2017.167486. [Full Text]

Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy. Devarasetty M1, Wang E, Soker S, Skardal A. Biofabrication. 2017; 9(2):021002.  [Abstract] 
U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis.
Caccuri F, Ronca R, Laimbacher AS, Berenzi A, Steimberg N, Campilongo F, Mazzuca P, Giacomini A, Mazzoleni G, Benetti A, Caselli E, Presta M, Di Luca D, Fraefel C, Caruso A.
Oncotarget. 2017 May 11. doi: 10.18632/oncotarget.17817. [Abstract]

Paclitaxel-releasing mesenchymal stromal cells inhibit the growth of multiple myeloma cells in a dynamic 3D culture system.
Bonomi A1, Steimberg N2, Benetti A, Berenzi A, Alessandri G, Pascucci L, Boniotti J, Coccè V, Sordi V, Pessina A, Mazzoleni G.Hematol Oncol. 2016 Jun 10. doi: 10.1002/hon.2306. [Abstract]

Adrenomedullin is a key Protein Mediating Rotary Cell Culture System that Induces the Effects of Simulated Microgravity on Human Breast Cancer Cells
Li Chen, Xi Yang, Xiang Cui, Minmin Jiang, Yu Gui, Yanni Zhang, Xiangdong Luo Microgravity Science and Technology
November 2015, Volume 27, Issue 6, pp 417-426 [Abstract]

Genome Wide Expression Profiling of Cancer Cell Lines Cultured in Microgravity Reveals Significant Dysregulation of Cell Cycle and MicroRNA Gene Networks
Prasanna Vidyasekar, Pavithra Shyamsunder, Rajpranap Arun, Rajalakshmi Santhakumar, Nand Kishore Kapadia, Ravi Kumar, and Rama Shanker Verma PLoS One. 2015; 10(8): e0135958. Published online 2015 Aug 21.  doi:  10.1371/journal.pone.0135958 [Abstract] [Full Text]

Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response.
Smith SJ, Ward JH, Tan C, Grundy RG, Rahman R. Oncotarget. 2015 Jun 2. [Abstract] [Full Text]

Liver-Tumor Hybrid Organoids for Modeling Tumor Growth and Drug Response In Vitro.
Skardal A, Devarasetty M, Rodman C, Atala A, Soker S. AnnBiomed Eng. 2015 Mar 17.doi: 10.1007/s10439-015-1298-3 [Abstract]

Human Ovarian Cancer Multicellular Spheroids: A Model for Testing Antiproliferation Activity of Devil's Club (Oplopanax horridus) and Anticancer Agents.
Tai J, Cheung SS, Hasman D. Planta Med. 2014 Jun;80(8-9):662-70. doi: 10.1055/s-0034-1368506. [Abstract]
Screening candidate metastasis-associated genes in three-dimensional HCC spheroids with different metastasis potential.
Chen R, Dong Y, Xie X, Chen J, Gao D, Liu Y, Ren Z, Cui J. Int J Clin Exp Pathol. 2014 Apr 15;7(5):2527-35. eCollection 2014. [Abstract] [Full Text] [Full Text pdf]
Dynamic expression patterns of differential proteins during early invasion of hepatocellular carcinoma.
Chen RX, Song HY, Dong YY, Hu C, Zheng QD, Xue TC, Liu XH, Zhang Y, Chen J, Ren ZG, Liu YK, Cui JF. PLoS One. 2014 Mar 10;9(3):e88543. doi: 10.1371/journal.pone.0088543. eCollection 2014.[Abstract] [Full Text] [Full Text pdf]
Rotary bioreactor culture can discern specific behavior phenotypes in Trk-null and Trk-expressing neuroblastoma cell lines. 
Redden RA, Iyer R, Brodeur GM, Doolin EJ.; In Vitro Cell Dev Biol Anim. 2014 Mar;50(3):188-93. doi: 10.1007/s11626-013-9716-z. [Abstract]
Antiproliferation activity of Devil's club (Oplopanax horridus) and anticancer agents on human pancreatic cancer multicellular spheroids.
Tai J, Cheung SS, Ou D, Warnock GL, Hasman D.; Phytomedicine. 2013 Nov 8. pii: S0944-7113(13)00401-7. doi: 10.1016/j.phymed.2013.10.003. [Abstract]

Ex-Vivo Dynamic 3-D Culture of Human Tissues in the RCCS™ Bioreactor Allows the Study of Multiple Myeloma Biology and Response to Therapy. 
Ferrarini M, Steimberg N, Ponzoni M, Belloni D, Berenzi A, Girlanda S, Caligaris-Cappio F, Mazzoleni G, Ferrero E. PLoS One. 2013 Aug 26;8(8):e71613. doi: 10.1371/journal.pone.0071613. [Abstract] [Full Text] 

Loss of Let-7 MicroRNA Upregulates IL-6 in Bone Marrow-Derived Mesenchymal Stem Cells Triggering a Reactive Stromal Response to Prostate Cancer.
Sung SY, Liao CH, Wu HP, Hsiao WC, Wu IH, Jinpu, Yu, Lin SH, Hsieh CL. PLoS One. 2013 Aug 19;8(8):e71637. doi: 10.1371/journal.pone.0071637 [Abstract] [Full Text] [Full Text pdf]
Characterization of Epstein-Barr virus reactivation in a modeled spaceflight system.
Brinley AA, Theriot CA, Nelman-Gonzalez M, Crucian B, Stowe RP, Barrett AD, Pierson DL. J Cell Biochem. 2013 Mar;114(3):616-24. doi: 10.1002/jcb.24403. [Abstract]
α-Catulin downregulates E-cadherin and promotes melanoma progression and invasion.
Kreiseder B, Orel L, Bujnow C, Buschek S, Pflueger M, Schuett W, Hundsberger H, de Martin R, Wiesner C. Int J Cancer. 2013 Feb 1;132(3):521-30. doi: 10.1002/ijc.27698. Epub 2012 Jul 14. [Abstract]
A unique 3D in vitro cellular invasion assay.
Quail DF, Maciel TJ, Rogers K, Postovit LM. J Biomol Screen. 2012 Sep;17(8):1088-95. doi: 10.1177/1087057112449863. Epub 2012 Jun 15. [Abstract]
Recapitulation of Tumor Heterogeneity and Molecular Signatures in a 3D Brain Cancer Model with Decreased Sensitivity to Histone Deacetylase Inhibition.
Smith SJ, Wilson M, Ward JH, Rahman CV, Peet AC, Macarthur DC, Rose FR, Grundy RG, Rahman R. PLoS One. 2012;7(12):e52335. doi: 10.1371/journal.pone.0052335. [Abstract] [Full Text] [Full Text PDF]
The use of an in vitro 3D melanoma model to predict in vivo plasmid transfection using electroporation.
Marrero B, Heller R. Biomaterials. 2012 Apr;33(10):3036-46. doi: 10.1016/j.biomaterials.2011.12.049. Epub 2012 Jan 13. [Abstract] [Full Text] [Full Text PDF]
Properties of mechano-transduction via simulated microgravity and its effects on intracellular trafficking of VEGFR's.
Puca A, Russo G, Giordano A. Oncotarget. 2012 Apr; 3(4):426-34. [Abstract]
Simulation of ex vivo bone marrow culture: Application to chronic myeloid leukaemia growth model.
Ma CYJ, Panoskaltsis N, Kumar R, Xu XY, Mantalaris A. Biochemical Engineering Journal. 2012 Feb 15;61:66-77. doi: 10.1016/j.bej.2011.10.002. [Abstract]
Microgravity assay of neuroblastoma: in vitro aggregation kinetics and organoid morphology correlate with MYCN expression.
Redden RA, Doolin EJ. In Vitro Cell Dev Biol Anim. 47(4):312-7, 2011 [Abstract]
Generation of a tumor spheroid in a microgravity environment as a 3D model of melanoma.
Marrero B, Messina JL, Heller R. In Vitro Cell Dev Biol Anim. 45: 523-34, 2009 [Abstract]
Development of a three-dimensional model of lung cancer using cultured transformed lung cells.
Vertrees RA, McCarthy M, Solley T, Popov VL, Roaten J, Pauley M, Wen X, Goodwin TJ.  Cancer Biol Ther 8:356-365, 2009 [Abstract]
In vitro three-dimensional modelling of human ovarian surface epithelial cells.
Lawrenson K, Benjamin E, Turmaine M, Jacobs I, Gayther S, Dafou D.  Cell Prolif. 42:385-93, 2009 [Abstract]
Three-dimensional in vitro cell biology models of ovarian and endometrial cancer.
Grun B, Benjamin E, Sinclair J, Timms JF, Jacobs IJ, Gayther SA, Dafou D.  Cell Prolif. 42:219-28, 2009 [Abstract]
Simulated microgravity decreases DNA repair capacity and induces DNA damage in human lymphocytes.
Kumari R, Singh KP, Dumond JW Jr.  J. Cell Biochem.107:723-31, 2009 [Abstract]
Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis.
Sung, S-Y, Hsieh, C-L, Law A, Zhau HE, Pathak S, A Multani AS, Lim S, Coleman IM, Wu L-C, Figg WD, Dahut WL, Nelson P, Lee JK, Amin MB, Lyles R, Johnstone PAJ, Marshall FF, Chung LWK.  Cancer Res 68:9996-10003, 2008 [Abstract] [Full Text] [Full Text pdf]
Characterization of primary breast carcinomas grown in three-dimensional cultures.
Becker JL, Blanchard DK.  J Surg Res 142: 256-262, 2007 [Abstract]
Heterogeneous breast tumoroids: An in vitro assay for investigating cellular heterogeneity and drug delivery.
Vamvakidou AP, Mondrinos MJ, Petushi SP, Garcia FU, Lelkes PI, Tozeren A.  J Biomol Screen 12:13-20, 2007 [Abstract]
Melanoma growth and tumorigenicity in models of microgravity.
Taga M, Yamauchi K, Odle J, Furian L, Sundaresan A, Ramesh GT, Pellis NR, Andrassy RJ, Kulkarni AD.  Aviat. Space Environ. Med. 77: 1113-1116, 2006 [Abstract]
Simulated Microgravity Impairs Leukemic Cell Survival Through Altering VEGFR-2/VEGF-A Signaling Pathway
Vincent L, Avancena P, Cheng J, Rafii S, Rabbany S;  Annals of Biomedical Engineering, 33: 1405-1410, 2005 [Abstract]
Spatial Composition of Prostate Cancer Spheroids in Mixed and Static Cultures.
Song H, David O, Clejan S, Giordano CL, Pappas-Lebeau H, Xu, L, O’Connor KC:  Tissue Eng. 10: 7/8, 1266-1276, 2004. [Abstract]
Nitrosative stress in rotated three-dimensional colorectal carcinoma cell cultures induces microtubule depolymerization and apoptosis.
Laguinge LM, Lin S, Samara RN, Salestiotis AN, Jessup JM.  Cancer Res. 64: 2643-2648, 2004 [Abstract] [Full Text] [Full Text pdf]
Galectin-3 Protects Human Breast Carcinoma Cells against Nitric Oxide-Induced Apoptosis: Implication of Galectin-3 Function during Metastasis.
Moon B, Lee YJ, Battle P, Jessup JM, Raz A, Kim HRC;  Amer. Jour. Path. 159: 1055-1060, 2001. [Abstract] [Full Text] [Full Text pdf]
Role of Galectin-3 in Breast Cancer Metastasis: Involvement of Nitric Oxide.
Song YK, Billiar TR, Lee YJ: Amer. Jour. Path. 160: 1069-1075, 2002. [Abstract] [Full Text] [Full Text pdf]
On-line Monitoring of Human Prostate Cancer Cells in a Perfusion Rotating Wall Vessel by Near-Infrared Spectroscopy.
Rhiel MH, Cohen MB, Arnold MA, Murhammer DW:  Biotechnol Bioeng 86: 852-861, 2004. [Abstract]
Cytoskeletal and Functional Changes in Bioreactor Assembled Thyroid Tissue Organoids Exposed to Gamma Radiation.
Green LM, Patel Z, Murray DK, Rightnar S, Burell CG, Gridley DS, Nelson GA:  J Radiat. Res. 43 (supplement): S213-S218, 2002. [Abstract] [Full Text pdf]
Evaluating Prostate Cancer Cell Culturing Methods: A Comparison of Cell Morphologies and Metabolic Activity
Winkenwerder JJ, Palechek PL, Reece JS, Saarinen MA, Arnold MA, Cohen MB, Murhammer DW: . Oncol.. Rep. 10: 783-789, 2003. [Abstract]
Simulated Microgravity Culture System for a 3-D Carcinoma
Nakamura K, Kuga H, Morisaki T, Baba E, Sato N, Mizumoto K, Sueshi K, Tanaka M, and Katano M:  Tissue Model Biotechniques 33:1068-1076, 2002. [Abstract]
Characteristics of Human Dendritic Cells Generated in a Microgravity Analog Culture System In Vitro
Savary C, Grazziuti ML, Przepiorka D, Tomasovic SP, McIntyre BW, Woodside DG, Pellis NR, Pierson DL, Rex JH:  Cell Dev Biol Anim 37:216-222, 2001. [Abstract]
Permanent Phenotypic and Genotypic Changes of Prostate Cancer Cells Cultured In a Three-Dimensional Rotating-Wall Vessel.
Rhee HW, Shau HE, Pathak S, Multani AS, Oennanen S, Visakorpi T, and Chung LWK:  In Vitro Cell Dev Biol Anim 37: 127-140, 2001. [Abstract]
A Novel Preclinical Model of Human Malignant Melanoma Utilizing Bioreactor Rotating-Wall Vessels.
Licato LL, Prieto VG, and Grimm EA: In Vitro Cell Dev Biol Anim 37: 121-126, 2001. [Abstract]
Microgravity Culture Reduces Apoptosis and Increases the Differentiation of a Human Colorectal Carcinoma Cell Line
Jessup JM, Frantz M, Sonmez-Alpan E, Locker J, Skena K, Waller H, Battle P, Nachman A, Bhatti, Weber ME, Thomas DA, Curbeam RL, Baker TL, and Goodwin TJ;  In Vitro Cell Dev Biol 36:367-373, 2000. [Abstract]
Biological Properties of Ulvan, a New Source of Green Seaweed Sulfated Polysaccharides, on Cultured Normal and Cancerous Colonic Epithelial Cells.
Kaeffer B, Bénard C, Lahaye M, Blottiére HM, Cherbut C;  Planta Med 65:6 527-531, 1999. [Abstract]
Tissue Models for the Development of Novel Anti-Cancer Therapies.
O’Connor KC; Three-Dimensional Cultures of Prostatic Cells: Pharmaceutical Research 16: 486-493, 1999. [Abstract]
Three-Dimensional Culture of a Mixed Mullerian Tumor of the Ovary: Expression Of In Vivo Characteristics.
Goodwin TJ, Prewett TL, Spaulding GF, Becker JL; In Vitro Cell Dev Biol Anim 33: 366-374, 1997. [Abstract]
Three-Dimensional Endothelial-Tumor Epithelial Cell Interactions in Human Cervical Cancers.
Chopra V, Dinh TV, and Hannigan EV;  In Vitro Cell Dev Biol Anim 33: 432-42, 1997. [Abstract]
Three-Dimensional Growth Patterns of Various Human Tumor Cell Lines in Simulated Microgravity of a NASA Bioreactor.
Ingram M, Techy GB, Saroufeem R, Yazan O, Narayan KS, Goodwin TJ and Spaulding GF;  In Vitro Cell Dev Biol Anim 33: 459-466, 1997. [Abstract]
Establishment of Three-Dimensional Human Prostate Organoid Coculture under Microgravity-Simulated Conditions: Evaluation of Androgen- Induced Growth and PSA Expression.
Zhau HE, Goodwin TJ, Shi-Ming Chang, Baker TL and Chung LWK.  In Vitro Cell Dev Bio Anim 33: 375-380, 1997. [Abstract]
Characterization of Autocrine Growth Factors, Their Receptors and Extracellular Matrix Present in Three-Dimensional Cultures of DU 145 Prostate Carcinoma Cells Grown in Simulated Microgravity.
O’Connor KC, Enmon RM, Dotson RS, Primavera AC and Clejan S. Tissue Engineering 3: 161- 171 , 1997. [Abstract]
Induction of Carcinoembryonic Antigen Expression in a Three-Dimensional Culture System.
Jessup JM, Brown D, Fitzgerald W, Ford RD, Nachman A, Goodwin TJ and Spaulding G. In Vitro Cell Dev Biol Anim 33: 352-7, 1997. [Abstract]
Cytogenetic, Morphologic and Oncogene Analysis of a Cell Line Derived from a Heterologous Mixed Mullerian Tumor of the Ovary.
Becker JL, Papenhausen PR and Widen RH: In Vitro Cell Dev Biol Anim 33: 325-31, 1997. [Abstract]
Effects of Simulated Microgravity on DU 145 Human Prostate Carcinoma Cells.
Clejan S, O’Conner KC, Cowger NL, Cheles MK, Haque S and Primavera AC:  Biotechnol Bioeng 50: 587-597, 1996. [Abstract]
Prospects for Use of Microgravity-Based Bioreactors to Study Three Dimensional Host-Tumor Interactions in Human Neoplasia.
Jessup JM, Goodwin TJ, Spaulding GF:  J Cell Biochem 51: 290-300, 1993. [Abstract]
Three-Dimensional Growth and Differentiation of Ovarian Tumor Cell Line in High Aspect Rotating Wall Vessel.
Becker JL, Prewett TL, Spaulding GF, Goodwin TJ:  Morphologic and Embryologic Considerations J Cell Biochem 51: 283-289, 1993. [Abstract]
Three Dimensional Modeling of T-24 Human Bladder Carcinoma Cell Line: A New Simulated Microgravity Vessel.
Prewett TL, Goodwin TJ, Spaulding GF:  J Tissue Culture Methods. 15: 29-36,1993. [Abstract]
Morphological Differentiation of Colon Carcinoma Cell Lines HT-29 and HT-29KM in Rotating Wall Vessels.
Goodwin TJ, Jessup JM, Wolf DA: In Vitro Cell Div Biol 28A:1 47-60, 1992. [Abstract]
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