Synthecon: 3D Culture Systems for 3D World!

Research Publications / Cardiovascular

β-Adrenergic stimuli and rotating suspension culture enhance conversion of human adipogenic mesenchymal stem cells into highly conductive cardiac progenitors. Islas JF,, Abbasgholizadeh R, Dacso C, Potaman VN, Navran S, Bond RA, Iyer D, Birla R, Schwartz RJ.  J Tissue Eng Regen Med. 2020; 14:306-318. [Abstract]

Novel Bioreactor Platform for Scalable Cardiomyogenic Differentiation from Pluripotent Stem Cell-Derived Embryoid Bodies.  Rungarunlert S, Ferreira JN, Dinnyes A. Methods Mol Biol. 2016 Apr 5. [Abstract]

A novel perfused rotary bioreactor for cardiomyogenesis of embryonic stem cells.
Teo A, Mantalaris A, Song K, Lim M Biotechnol Lett. 2014; 36(5):947-60. [Abstract]

Structural and biomechanical characterizations of porcine myocardial extracellular matrix. 
Wang B, Tedder ME, Perez CE, Wang G, de Jongh Curry AL, To F, Elder SH, Williams LN, Simionescu DT, Liao J. J Mater Sci Mater Med. 2012 May [Abstract]
Enhanced cardiac differentiation of mouse embryonic stem cells by use of the slow-turning, lateral vessel (STLV) bioreactor.
Rungarunlert S, Klincumhom N, Bock I, Nemes C, Techakumphu M, Pirity MK, Dinnyes A. Biotechnol Lett. 2011 ;33(8):1565-73.  [Abstract]
Computational modeling for the optimization of a cardiogenic 3D bioprocess of encapsulated embryonic stem cells.
Consolo F, Bariani C, Mantalaris A, Montevecchi F, Redaelli A, Morbiducci U. Biomech Model Mechanobiol., Apr 2011 [Abstract]
Differential translocation of nuclear factor-kappaB in a cardiac muscle cell line under gravitational changes.
Kwon O, Tranter M, Jones WK, Sankiovic JM, Banerjee RK. J Biomech Eng. 131:064503, 2009 [Abstract]
Bioreactor Cultivation Enhances NTEB Formation and Differentiation of NTES Cells into Cardiomyocytes.
Lu S, Liu S, He W, Duan C, Li Y, Liu Z, Hao T, Wang Y, Li D, Wang C, Gao S. Cloning Stem Cells 10:363-370, 2008 [Abstract]
Rotating versus perfusion bioreactor for the culture of engineered vascular constructs based on hyaluronic acid.
Arrigoni C, Chitto A, Mantero S, Remuzzi A. Biotechnol Bioeng. 100: 988-997, 2008 [Abstract]
Combined administration of G- CSF and GM-CSF stimulates monocyte-derived pro-angiogenic cells in patients with acute myocardial infarction.
Bruno S, Bussolati B, Scacciatella P, Marra S, Sanavio F, Tarella C, Camussi G. Cytokine 34: 56-65, 2006 [Abstract]
Creation of engineered cardiac tissue in vitro from mouse embryonic stem cells.
Guo XM, Zhao YS, Chang HX, Wang CY, Ling-Ling E, Zhang XA, Duan CM, Dong LZ, Jiang H, Li J, Song Y, Yang XJ. Circulation 113 :2229-2237, 2006. [Abstract]
Impact of modeled microgravity on microvascular endothelial cells.
Cotrupi S, Ranzani D, Maier JA: Biochem Biophys Acta 1746(2):163-168, 2005. [Abstract in English, Article in Chinese]
Pilot Study of Neonatal Rat Cardiac Myocytes Cultured for Three-Dimensional Modeling in Simulated Microgravity.
Yang F, Li YH, Nie JL; Zhongguo Xiu Fu Chong Juan Wai Ke Za Zhi Mar; 18(2):119-122, 2004. [Abstract]
Cultivation in Rotating Bioreactors Promotes Maintenance of Cardiac Myocyte Electrophysiology and Molecular properties.
Bursac N, Papadaki M, White JA, Eisenberg SR, Vunjak-Novakovic G, Freed L: Tissue Eng. Vol. 9, No.6, 1243-1253, 2003. [Abstract]
Cardiac Tissue Engineering: Characteristics of in Unison Contracting Two- and Three-dimensional Neonatal Rat Ventricle Cell (Co)-Cultures.
Van Luyn MA, Tio RA, Gallego y van Seijen XJ, Plantinga JA, de Leij LFMH, DeJongste ML, van Wachem PB: Biomaterials 23: 4793-4801, 2002. [Article in Chinese, Abstract in English]
Experimental Study of Cardiac Muscle Tissue Engineering in Bioreactor.
Liu X, Wang CY, Guo XM, OuYang WQ: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Feb;25(1):7-12, 2003 [Abstract in English, Article in Chinese]
Advances in the Mechanisms of Cell Delivery to Cardiovascular Scaffolds: Comparison of Two Rotating Cell Culture Systems.
Sutherland FW, Perry TE, Nasseri BA, Wang J, Kaushal S, Guleserian KJ, Martin DP, Vacant JP, Mayer JE Jr.  ASAIO J 48:346-9, 2002. [Abstract]
Tissue Engineering of Functional Cardiac-Muscle: Molecular, Structural, and Electrophysiological Studies.
Papadaki M, Bursac N, Langer R, Merok J, Vunjak-Novakovic G, Freed LE: Am J Physiol Heart Physiol 280:H168-178, 2001. [Abstract] [Full Text] [Full Text pdf]
Simulated Microgravity and Hypergravity Attenuate Heart Tissue Development in Explant Culture.
Lwigale PY, Thurmond JE, Norton WN, Spooner BS, Wiens DJ:  Cells Tissues Organs 167: 171-183, 2000. [Abstract]
Cardiac Tissue Engineering: Cell Seeding, Cultivation Parameters, and Tissue Construct Characterization.
Carrier RL, Papadaki M, Rupnick M, Schoen F, Bursac N, Langer R, Freed LE, Vunjak-Novakovic G: Biotechnol Bioeng 64: 580-589, 1999. [Abstract]
Cardiac Muscle Tissue Engineering: Toward an In Vitro Model for Electrophysiological Studies.
Bursac N, Papadaki M,Cohen AJ, Schoen FJ, Eisenberg SR, Carrier R, Vunjak-Novakovic G, Freed LE:  Am J Physiol 277: Pt2 H433-444, 1999. [Full Text[Full Text pdf]
Neonatal Rat Heart Cells Cultured in Simulated Microgravity.
Akins RE, Schroedl NA, Gonda SR and Hartzell CR:  In Vitro Cell Dev Biol Anim 33: 337-343, 1997. [Abstract]
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