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Research Publications / Cell Signaling

The dynamic adaptation of primary human endothelial cells to simulated microgravity. Cazzaniga A, Locatelli L, Castiglioni S, Maier JAM.   FASEB J. 2019;33(5):5957-5966.  [Abstract]

Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection.
Feger BJ, Thompson JW, Dubois LG, Kommaddi RP, Foster MW, Mishra R, Shenoy SK, Shibata Y, Kidane YH, Moseley M, Carnell LS, Bowles DE. Sci Rep. 2016 Sep 27;6:34091. doi: 10.1038/srep34091. [Abstract] [Full Text]

IL-36γ Augments Host Defense and Immune Responses in Human Female Reproductive Tract Epithelial Cells
Sean M. Winkle, Andrea L. Throop and Melissa M. Herbst-Kralovetz. Front. Microbiol., 17 June 2016 | [Full Text]

The effect of Smads signal pathway on the osteogenesis of human periodontal ligament stem cells in simulated microgravity.
Li Y, Li S, Niu ZY, Bao B, Shi X.; Shanghai Kou Qiang Yi Xue. 2012 Jun;21(3):246-50. (Article in Chinese) [Abstract]
Properties of mechano-transduction via simulated microgravity and its effects on intracellular trafficking of VEGFR's.
Puca A, Russo G, Giordano A. Oncotarget. 2012 Apr; 3(4):426-34. [Abstract]
Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions.
Barrila J, Radtke AL, Crabbé A, Sarker SF, Herbst-Kralovetz MM, Ott CM, Nickerson CA. Nat Rev Microbiol. 2010 Nov;8(11):791-801 [abstract]
Interaction of SDF-1alpha and CXCR4 plays an important role in pulmonary cellular infiltration in differentiation syndrome.Zhou J, Hu L, Cui Z, Jiang X, Wang G, Krissansen GW, Sun X. Int J Hematol 91:293-302, 2010 [Abstract]
Analysis of Interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells.
Radtke AL, Wilson JW, Sarker S, Nickerson CA. PLoS One 29;5:e15750, 2010 [abstract]
The expression of growth factors and their receptors in retinal and endothelial cells cocultured in the rotating bioreactor.
Kumar R, Harris-Hooker S, Sanford GL. Ethn Dis 18(2 Suppl): S2-44-50, 2008 [Abstract]
Simulated Microgravity Impairs Leukemic Cell Survival Through Altering VEGFR-2/VEGF-A Signaling Pathway
Vincent L, Avancena P, Cheng J, Rafii S, Rabbany S,:Annals of Biomedical Engineering, 33: 1405-1410, 2005 [Abstract]
Low-Shear Modeled Microgravity: A Global Environmental Regulatory Signal Affecting Bacterial Gene Expression, Physiology, and Pathogenesis.
Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, LeBlanc CL,et al.: Journal of Microbiological Methods 54 1-11, 2003. [Abstract]
Tri-dimensional Prostate Cell Cultures in Simulated Microgravity and Induced Changes in Lipid Second Messengers and Signal Transduction.
Clejan S, O’Connor K and Rosenweig N: J Cell Mol Med 5:60-73, 2001. [Abstract]
Selected Contribution: PKC Activation Inhibits Ca(2+) Signaling in Tracheal Epithelial Cells Kept in Simulated Microgravity.
Felix JA, Dirksen ER, Woodruff ML: J Appl Physiol 89: 2855-2864, 2000. [Abstract][Full Text] [Full Text pdf]
Mechanical Stimulation Initiates Intercellular Ca2+ Signaling in Intact Tracheal Epithelium Maintained Under Normal Gravity and Simulated Microgravity.
Felix JA, Chaban VV, Woodruff ML, Dirksen ER:  Am J Respir Cell Mol Biol 18: 602-610, 1998 [Abstract][Full Text] [Full Text pdf]
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