Synthecon: 3D Culture Systems for 3D World!

This is a confocal laser scanning micrograph of a 3-D lung model formed in the RCCS, derived from the A549 lung epithelial cell line stained with an antibody against the tight junctional marker, beta catenin. Photo credit(s) – Aurélie Crabbé; Cheryl Nickerson

This is a confocal laser scanning micrograph of a 3-D lung model formed in the RCCS ,derived from the A549 lung epithelial cell line stained with an antibody against the mucin marker, MUC5AC. Photo credit(s) –Aurélie Crabbé; Cheryl Nickerson

This is a confocal laser scanning micrograph of a 3-D lung model formed in the RCCS, derived from the A549 lung epithelial cell line stained with an antibody against the mucin marker, MUC5AC. Photo credit(s) –Aurélie Crabbé; Cheryl Nickerson

3-D HT-29 colon model
Description - This is a scanning electron micrograph (350X) of a 3-D colon model formed in the Synthecon RCCS, derived from the HT-29 colonic epithelial cell line. Photo credit(s) – Mark Ott; Cheryl Nickerson

3D Cell Models for Tissue Engineering in the RCCS

Our RCCS bioreactor system has been used to form a variety of 3D cell models for various applications.

Here are a few applications for this novel system:

Co-culture
Spheroid formation
Tissue engineering (with or without scaffolds)
Host-pathogen studies
Formation of vascaularized tissue
Explant maintenance
Cell therapy and regenerative medicine
Stem cell expansion
Stem cell differentiation of cells
Modeling microgravity
Vascular graft culture