Synthecon: 3D Culture Systems for 3D World!

Research Publications / General Review Articles

Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes
of Age.  Barrila J, Crabbé A, Yang J, Franco K, Nydam SD, Forsyth RJ, Davis RR, Gangaraju S, Ott M, Coyne, CB, Bissell MJ, Nickerson CA. Infection and Immunity 2018; 86(11): e00282-18.  [Abstract]

Effect of Rotation on Scaffold Motion and Cell Growth in Rotating Bioreactors.
Varley MC, Markaki AE, Brooks RA. Tissue Eng Part A. 2017 Jan 26. doi: 10.1089/ten.TEA.2016.0357. [Abstract]

Three-Dimensional Rotating Wall Vessel-Derived Cell Culture Models for Studying Virus-Host Interactions.
Gardner JK, Herbst-Kralovetz MM.Viruses. 2016 Nov 9;8(11). pii: E304. [Abstract] [FullText]

Scaffold-free Tissue Formation Under Real and Simulated Microgravity Conditions.
Aleshcheva G, Bauer J, Hemmersbach R, Slumstrup L, Wehland M, Infanger M, Grimm D.Basic Clin Pharmacol Toxicol. 2016 Oct;119 Suppl 3:26-33. doi: 10.1111/bcpt.12561. [Abstract]

The International Space Station: an Extreme Environment for Key Host-Microbe Discoveries
C. Mark Ott, Thomas Marshburn, and Cheryl A. Nickerson. Microbe—Volume 11, Number 6, 2016, Pages 253-261. [Abstract]

From Single Cells to Engineered and Explanted Tissues: New Perspectives in Bacterial Infection Biology.
Bergmann S, Steinert M.Int Rev Cell Mol Biol. 2015;319:1-44. doi: 10.1016/bs.ircmb.2015.06.003. Epub 2015 Jul 21. [Abstract]

Growing tissues in real and simulated microgravity - new methods for tissue engineering.
Grimm D, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, Ulbrich C, Magnusson NE, Infanger M, Bauer J.; Tissue Eng Part B Rev. 2014 Apr 4. [Epub ahead of print] [Abstract]
Culturing and applications of rotating wall vessel bioreactor derived 3D epithelial cell models. *Video Article
Radtke AL, Herbst-Kralovetz MM. J Vis Exp. 2012 Apr 3;(62). pii: 3868. doi: 10.3791/3868. [abstract]
3D sample preparation for orthopaedic tissue engineering bioreactors. 
Cartmell SH, Rathbone S, Jones G, Hidalgo-Bastida LA. (Textbook chapter in 3D Cell Culture: Methods and Protocols, ISBN 978-1-60761-983-3) [abstract]
Bioreactor systems for bone tissue engineering.
Rauh J, Milan F, Günther KP, Stiehler M. Tissue Eng Part B Rev. 2011 Aug;17(4):263-80. [Abstract]
Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions.
Barrila J, Radtke AL, Crabbé A, Sarker SF, Herbst-Kralovetz MM, Ott CM, Nickerson CA. Nat Rev Microbiol. 2010 Nov;8(11):791-801 [Abstract]
Spaceflight and modeled microgravity effects on microbial growth and virulence.
Rosenzweig JA, Abogunde O, Thomas K, Lawal A, Nguyen YU, Sodipe A, Jejelowo O. Appl Microbiol Biotechnol 85:885-891, 2010 [Abstract] [Full Text] [Full Text pdf]
The application of low shear modeled microgravity to 3-D cell biology and tissue engineering.
Navran S. Biotechnol Ann Rev. 14: 275-296, 2008 [Abstract]
Studying host-pathogen interactions in 3-D: organotypic models for infectious disease and drug development.
Nickerson CA, Richter EG, Ott CM; J Neuroimmune Pharmacol. 2:26-31, 2007 [Abstract]
Low-Shear Modeled Microgravity: A Global Environmental Regulatory Signal Affecting Bacterial Gene Expression, Physiology, and Pathogenesis. Nickerson CA, Ott CM, Wilson JW, Ramamurthy R, LeBlanc CL,et al. Journal of Microbiol Methods 54:1-11, 2003 [Abstract]
Optimized Suspension Culture: The Rotating-Wall Vessel
Hammond TG, and Hammond JM: . Am J Physiol Renal Physiol 281: F12-F25, 2001. [Abstract] [Full Text] [Full Text pdf]

Growing Tissues in Microgravity.
Unsworth BR and Lelkes PI:  Nature Medicine 4: 901-907, 1998.
Tissue Culture in Microgravity.
 Duray PH, Hatfill SJ and Pellis NR: Science & Medicine, 4: 45-55, 1997. [Abstract]
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