Synthecon: 3D Culture Systems for 3D World!

Research Publications / Neural/ Neuralendocrine

The Rotary Cell Culture System increases NTRK3 expression and promotes neuronal differentiation and migratory ability of
neural stem cells cultured on collagen sponge.   Cui Y, Yin Y,  Zou Y, Zhao Y, Han J, Xu B, Chen B, Xiao Z, Song H, Shi Y,  Xue W, Ma X and Dai J.  Stem Cell Research & Therapy (2021) 12:298.  [Full Text]

An integrated biomanufacturing platform for the large-scale expansion and neuronal differentiation of human pluripotent stem cell-derived neural progenitor cells. Srinivasan G, Morgan D, Varun D, Brookhouser N, Brafman DA. Acta Biomater. 2018 74:168-179. [Abstract]

Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors. DiStefano T, Chen HY, Panebianco C, Kaya KD, Brooks MJ, Gieser L, Morgan NY, Pohida T, Swaroop A. Stem Cell Reports. 2018;10(1):300-313. [Full Text]

Engineering three dimensional micro nerve tissue using postnatal stem cells from human dental apical papilla.
Kim BC, Jun SM, Kim SY, Kwon YD, Choe SC, Kim EC, Lee JH, Kim J, Suh JF, Hwang YS. Biotechnol Bioeng. 2016 Oct 24. doi: 10.1002/bit.26205. [Abstract]

3D tissue-like assemblies: A novel approach to investigate virus-cell interactions.
Goodwin TJ, McCarthy M, Cohrs RJ, Kaufer BB. Methods. 2015 May 15. pii: S1046-2023(15)00203-0. doi: 10.1016/j.ymeth.2015.05.010. [Abstract]

RCCS Bioreactor-Based Modelled Microgravity Induces Significant Changes on IN Vitro 3D Neuroglial Cell Cultures.
Morabito C, Steimberg N, Mazzoleni G, Guarnieri S, Fano-Illic G, Mariggio MA. Biomed Res Int. 2015 Jan 13; 2015:754283. doi 10:1155/2015/754283 [Abstract] [Full Text]

Tissue-Engineered Nerve Constructs Under a Microgravity System for Peripheral Nerve Regeneration.
Luo H, Zhu B, Zhang Y, Jin Y. Tissue Eng Part A. 2014 Sep 16. (Epub ahead of print) [Abstract]
Rotary bioreactor culture can discern specific behavior phenotypes in Trk-null and Trk-expressing neuroblastoma cell lines.
Redden RA, Iyer R, Brodeur GM, Doolin EJ.; In Vitro Cell Dev Biol Anim. 2014 Mar;50(3):188-93. doi: 10.1007/s11626-013-9716-z. [Abstract]
Beta-adrenoceptor pathway enhances mitochondrial function in human neural stem cells via rotary cell culture system.
Chiang MC, Lin H, Cheng YC, Yen CH, Huang RN, Lin KH. J Neurosci Methods. 2012 Jun 15;207(2):130-6.[abstract]
The simulated microgravity enhances the differentiation of mesenchymal stem cells into neurons.
Chen J, Liu R, Yang Y, Li J, Zhang X, Li J, Wang Z, Ma J. Neurosci Lett.;505(2):171-5. Nov 2011 [Abstract]
Microgravity assay of neuroblastoma: in vitro aggregation kinetics and organoid morphology correlate with MYCN expression.
Redden RA, Doolin EJ. In Vitro Cell Dev Biol Anim. 47(4):312-7, 2011 [Abstract]
Impact of Scaffold Micro and Macro Architecture on Schwann Cell Proliferation under Dynamic Conditions in a Rotating Wall Vessel Bioreactor.
Valmikinathan CM, Hoffman J, Yu X. Mater Sci Eng C Mater Biol Appl. 2011 Jan 1;31(1):22-29.[Abstract]
Effects of parabolic flight on redox status in SHSY5Y cells
Bi L, Qu LN, Huang ZM, Wang CY, Li Q, Tan YJ, Li YH. Sheng Li Xue Bao. 61: 445-50,2009 [Abstract][Full Text pdf]
Reconstruction of Functional Cortical-Like Tissues from Neural Stem and Progenitor Cells.
Ma W, Tavakoli T, Chen S, Maric D, Liu JL, O'Shaughnessy TJ.Tissue Eng Part A 14: 1687-1697, 2008 [Abstract]
Whole organ culture of the postnatal sensory inner ear in simulated microgravity.
Hahn H, Muller M, Lowenheim H. J Neurosci Methods 171: 60-71, 2008 [Abstract]
The role of connexins in the differentiation of NT2 cells in Sertoli-NT2 cell tissue constructs grown in the rotating wall bioreactor.
Shamekh R, Cameron DF, Willing AE, Saporta S:Exp Brain Res 170: 277-284, 2006. [Abstract]
Rapid Differentiation of NT2 Cells in a Sertoli-NT2 Cell Tissue Constructs Grown in the Rotating Wall Bioreactor.
Saporta S, Willing AE, Shamekh R, Bickford P, Paredes D, Cameron DF: Brain Res Bull 64: 347-356, Dec 2004 [Abstract]
Formation and Structure of Transplantable Tissue Constructs Generated in Simulated Microgravity From Sertoli Cells and Neuron Precursors.
Cameron DF, Hushen JJ, Colina L, Mallery J, Willing A, Sanberg PR, Saporta S:Cell Transplant 13: 755-763, 2004. [Abstract]
Neural Stem Cell Differentiation in a Cell-collagen-bioreactor Culture System.
Lin HJ, O’Shaughnessy TJ, Kelly J, Ma W: Develop. Brain Res 153: 163-173, 2004. [Abstract]
Effect of Culture in a Rotating Wall Bioreactor on the Physiology of Differentiated Neuron-Like PC12 and SH-SY5Y Cells.
Wang SS and Good TA:J Cell Biochem 83:574-584, 2001. [Abstract]
Neural Precursor Cells Form Rudimentary Tissue Like Structures in a Rotating-Wall Vessel Bioreactor.
Low, H.P., Savarese, T.M., and Schwartz, W.J.: In Vitro Cell Dev Biol Anim 37: 141-147, 2001. [Abstract]
Simulated Microgravity Conditions Enhance Differentiation of Cultured PC12 Cells Towards the Neuroendocrine Phenotype.
Lelkes P. et al.: InVitro Cell Dev Biol Anim 34: 316-325, 1998. [Abstract]
Single Use 3D BioreactorsAutoclavable 3D BioreactorsStem Cell Culture SystemsPerfusion Bioreactors Nanobiomatrix ScaffoldsBiostructure Matrix Scaffolds
Synthecon, Incorporated | 8977 Interchange Dr. | Houston, Texas 77054 | (713) 741-2582 | Toll Free (800) 853-0740
Website by SinyakCreative
© 2022 Synthecon, Incorporated, All Rights Reserved