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Research Publications / Reproductive

In Vitro Growth of Mouse Preantral Follicles Under Simulated Microgravity.
Zhang S, Wu Y, Weng Y, Xu Z, Chen W, Zheng D, Lin W, Liu J, Zhou Y. 
J Vis Exp. 2017 Dec 17;(130). doi: 10.3791/55641. [Full Text]

Effect Of Microgravity On Aromatase Expression In Sertoli Cells.
Cirelli E1, De Domenico E, Botti F, Massoud R, Geremia R, Grimaldi P. Sci Rep. 2017 Jun 14;7(1):3469. doi: 10.1038/s41598-017-02018-2. [Abstract]

Human three-dimensional endometrial epithelial cell model to study host interactions with vaginal bacteria and Neisseria gonorrhoeae.
Łaniewski P, Gomez A, Hire G, So M, Herbst-Kralovetz MM.Infect Immun. 2017 Jan 4. pii: IAI.01049-16. doi: 10.1128/IAI.01049-16.  [Abstract]

IL-36γ Augments Host Defense and Immune Responses in Human Female Reproductive Tract Epithelial Cells
Sean M. Winkle, Andrea L. Throop and Melissa M. Herbst-Kralovetz. Front. Microbiol., 17 June 2016 | [Full Text]

Simulated Microgravity Using a Rotary Culture System Compromises the In Vitro Development of Mouse Preantral Follicles.
Zhang S, Zheng D, Wu Y, Lin W, Chen Z, Meng L, Liu J, Zhou Y1,.PLoS One. 2016 Mar 10;11(3):e0151062. doi: 10.1371/journal.pone.0151062. eCollection 2016. [Abstract] [Full Text]

A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance.
McConkey CA1, Delorme-Axford E, Nickerson CA, Kim KS, Sadovsky Y, Boyle JP, Coyne CB.Sci Adv. 2016 Mar 4;2(3):e1501462. doi: 10.1126/sciadv.1501462. eCollection 2016. [Abstract] 

In vitro model of placental trophoblast differentiation and cytomegalovirus infection.
Swan KF, Ferris M, Pridjian G, Morris CA, Sullivan DE. Pregnancy Hypertens. 2015 Jan;5 (1): 155-6. doi: 10.1016/j.preghy.2014.10.323.[Abstract] [Full Text pdf]
Mouse undifferentiated spermatagonial stem cells cultured as aggregates under simulated microgravity.
Zhang X, Li L, Bai Y, Shi R, Wei H, Zhang S. Andrologia. 2014 Nov;46(9):1013-21. doi: 10.111/and.12189. [Abstract]

Effect of Culture in Simulated Microgravity on the Development of Mouse Embryonic Testes.
Nowacki D, Klinger FG, Mazur G, Felici MD. Adv Clin Exp Med. 2015 Sep-Oct;24(5):769-74. doi: 10.17219/acem/27920. [Abstract] [Full Text]
Human Ovarian Cancer Multicellular Spheroids: A Model for Testing Antiproliferation Activity of Devil's Club (Oplopanax horridus) and Anticancer Agents.
Tai J, Cheung SS, Hasman D. Planta Med. 2014 Jun;80(8-9):662-70. doi: 10.1055/s-0034-1368506. [Abstract]
Mycoplasma genitalium Infection Activates Cellular Host Defense and Inflammation Pathways in a 3-Dimensional Human Endocervical Epithelial Cell Model.
McGowin CL, Radtke AL, Abraham K, Martin DH, Herbst-Kralovetz M. J Infect Dis. 2013 Jun;207(12):1857-68. doi: 10.1093/infdis/jit101. [Abstract]
Microbial Products Alter the Expression of Membrane-Associated Mucin and Antimicrobial Peptides in a 3-D Human Endocervical Epithelial Cell Model.
Radtke AL, Quayle AJ, Herbst-Kralovetz MM.  Biol Reprod. 2012 Dec 6;87(6):132. doi: 10.1095/biolreprod.112.103366. Print 2012 Jun. [Abstract] [Full Text] [Full Text pdf]
Tail-suspended model simulating mouse oocytes maturation inhibited with microgravity.
Wu C, Li L, Wei H, Wu Z, Jiang Q, Zhang S.;  Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2012 Aug;29(4):687-90, 696. (Article in Chinese) [Abstract in English]
Microgravity promotes differentiation and meiotic entry of postnatal mouse male germ cells.
Pellegrini M, Di Siena S, Claps G, Di Cesare S, Dolci S, Rossi P, Geremia R, Grimaldi P.: PLoS One 4:5(2):e9064, 2010 [Abstract] [Full Text] [Full Text pdf]

A major effect of simulated microgravity on several stages of preimplantation mouse development is lethality associated with elevated phosphorylated SAPK/JNK.
Wang Y1, Xie Y, Wygle D, Shen HH, Puscheck EE, Rappolee DA.
Reprod Sci. 2009 Oct;16(10):947-59. doi: 10.1177/1933719109337544. Epub 2009 Jun 22.  [Full Text]

Direct effects of microgravity on testicular function: analysis of hystological, molecular and physiologic parameters.
Ricci G, Esposito R, Catizone A, Galdieri M.; J Endocrinol Invest 31:229-237, 2008 [Abstract
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