Synthecon: 3D Culture Systems for 3D World!

Research Publications / Stem Cells

Exosomes derived from umbilical cord mesenchymal stem cells in mechanical environment show improved osteochondral activity via upregulation of LncRNA H19.  Yan L,  Liu G, and Wu X. J Orthop Translat 26, 2021; 111–120 [Full Text]

Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells following transfection with Indian hedgehog and sonic hedgehog using a rotary cell culture system.  Chen L, Liu G, Li W, Wu X.   Cell Mol Biol Lett. 2019; 24:16. [Abstract]

An integrated biomanufacturing platform for the large-scale expansion and neuronal differentiation of human pluripotent stem cell-derived neural progenitor cells. Srinivasan G, Morgan D, Varun D, Brookhouser N, Brafman DA. Acta Biomater. 2018 74:168-179. [Abstract]

Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells. Yamashita T, Takayama K, Sakurai F, Mizuguchi H.  Biochem Biophys Res Commun. 2018 496(4):1269-1275. [Abstract]
Advanced 3D models culture to investigate mesenchymal stromal cells of the human dental follicle.
Steimberg N, Angiero F, Farronato D, Berenzi A, Cossellu G, Ottonello A, Kaigler D, Mazzoleni G.Tissue Eng Part C Methods. 2018 Jan 12. doi: 10.1089/ten.TEC.2017.0428. [Abstract]

Accelerated and Improved Differentiation of Retinal Organoids from Pluripotent Stem Cells in Rotating-Wall Vessel Bioreactors.
DiStefano T, Chen HY, Panebianco C, Kaya KD, Brooks MJ, Gieser L, Morgan NY, Pohida T, Swaroop A. Stem Cell Reports. 2018 Jan 9;10(1):300-313. doi: 10.1016/j.stemcr.2017.11.001. [Full Text]

Coculture of meniscus cells and mesenchymal stem cells in simulated microgravity.
Weiss WM, Mulet-Sierra A, Kunze M, Jomha NM, Adesida AB.NPJ Microgravity. 2017 Nov 10;3:28. doi: 10.1038/s41526-017-0032-x. eCollection 2017. [Full Text]

Mesenchymal stem cells support growth and organization of host-liver colorectal-tumor organoids and possibly resistance to chemotherapy.
Devarasetty M1, Wang E, Soker S, Skardal A.
Biofabrication. 2017 Jun 7;9(2):021002. doi: 10.1088/1758-5090/aa7484. [Abstract] 

The combination of three dimensional and rotary cell culture system promotes the proliferation and maintains the differentiation potential of rat BMSCs. Tang Y, Xu Y, Xiao Z, Zhao Y, Li J, Han S, Chen L, Dai B, Wang L, Bing Chen B &  Wang H. Scientific Reports 2017; 7:192 [Full Text]

Effect of microgravity on the mesenchymal stem cell characteristics of limbal fibroblasts.
Pao SI, Chien KH, Lin HT, Tai MC, Chen JT, Liang CM. J Chin Med Assoc. 2017 May 18. pii: S1726-4901(17)30109-0. doi: 10.1016/j.jcma.2017.01.008. [Abstract] [Full Text]

U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis.
Caccuri F, Ronca R, Laimbacher AS, Berenzi A, Steimberg N, Campilongo F, Mazzuca P, Giacomini A, Mazzoleni G, Benetti A, Caselli E, Presta M, Di Luca D, Fraefel C, Caruso A.
Oncotarget. 2017 May 11. doi: 10.18632/oncotarget.17817. [Abstract]

Aligned Nanofibrous Cell-Derived Extracellular Matrix for Anisotropic Vascular Graft Construction.
Xing Q, Qian Z, Tahtinen M, Yap AH, Yates K, Zhao F.Adv Healthc Mater. 2017 May;6(10). doi: 10.1002/adhm.201601333. Epub 2017 Feb 9. [Abstract]

Three-dimensional simulated microgravity culture improves the proliferation and odontogenic differentiation of dental pulp stem cell in PLGA scaffolds implanted in mice.
Li Y, He L, Pan S, Zhang L, Zhang W, Yi H, Niu Y. Mol Med Rep. 2017 Feb;15(2):873-878. doi: 10.3892/mmr.2016.6042. Epub 2016 Dec 14. [Abstract]

Transfection of the IHH gene into rabbit BMSCs in a simulated microgravity environment promotes chondrogenic differentiation and inhibits cartilage aging. 
Liu PC, Liu K1, Liu JF, Xia K, Chen LY, Wu X. Oncotarget. 2016 Sep 6;7(39):62873-62885. doi: 10.18632/oncotarget.11871. [Abstract] [FullText]

Engineering three dimensional micro nerve tissue using postnatal stem cells from human dental apical papilla.
Kim BC, Jun SM, Kim SY, Kwon YD, Choe SC, Kim EC, Lee JH, Kim J, Suh JF, Hwang YS. Biotechnol Bioeng. 2016 Oct 24. doi: 10.1002/bit.26205. [Abstract]

Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling.
Wilkinson DC, Alva-Ornelas JA, Sucre JM, Vijayaraj P, Durra A, Richardson W, Jonas SJ, Paul MK, Karumbayaram S, Dunn B, Gomperts BN. Stem Cells Transl Med. 2016 Sep 15. pii: sctm.2016-0192. [Abstract] [Full Text]

Numerical Simulation of Mass Transfer and Three-Dimensional Fabrication of Tissue-Engineered Cartilages Based on Chitosan/Gelatin Hybrid Hydrogel Scaffold in a Rotating Bioreactor.
Zhu Y, Song K, Jiang S, Chen J, Tang L, Li S, Fan J, Wang Y, Zhao J, Liu T.Appl Biochem Biotechnol. 2016 Aug 15. [Abstract]

Paclitaxel-releasing mesenchymal stromal cells inhibit the growth of multiple myeloma cells in a dynamic 3D culture system.
Bonomi A1, Steimberg N2, Benetti A, Berenzi A, Alessandri G, Pascucci L, Boniotti J, Coccè V, Sordi V, Pessina A, Mazzoleni G.Hematol Oncol. 2016 Jun 10. doi: 10.1002/hon.2306. [Abstract]

Uniform Embryoid Body Production and Enhanced Mesendoderm Differentiation with Murine Embryonic Stem Cells in a Rotary Suspension Bioreactor.
Lei X, Deng Z, Duan E. Methods Mol Biol. 2016 Apr 27. [Abstract]

Novel Bioreactor Platform for Scalable Cardiomyogenic Differentiation from Pluripotent Stem Cell-Derived Embryoid Bodies.
Rungarunlert S, Ferreira JN, Dinnyes A. Methods Mol Biol. 2016 Apr 5. [Abstract]

Induction of mesenchymal stem cell chondrogenic differentiation and functional cartilage microtissue formation for in vivo cartilage regeneration by cartilage extracellular matrix-derived particles.
Yin H, Wang Y, Sun Z, Sun X, Xu Y, Li P, Meng H, Yu X, Xiao B, Fan T, Wang Y, Xu W, Wang A, Guo Q, Peng J, Lu S.Acta Biomater. 2016 Jan 20. pii: S1742-7061(16)30024-1. doi: 10.1016/j.actbio.2016.01.024. [Abstract]

Hypoxia Created Human Mesenchymal Stem Cell Sheet for Prevascularized 3D Tissue Construction.
Zhang L, Xing Q, Qian Z, Tahtinen M, Zhang Z, Shearier E, Qi S, Zhao F.Adv Healthc Mater. 2015 Dec 14. doi: 10.1002/adhm.2 [Abstract]

Adrenomedullin is a key Protein Mediating Rotary Cell Culture System that Induces the Effects of Simulated Microgravity on Human Breast Cancer Cells
Li Chen, Xi Yang, Xiang Cui, Minmin Jiang, Yu Gui, Yanni Zhang, Xiangdong Luo Microgravity Science and Technology
November 2015, Volume 27, Issue 6, pp 417-426 [Abstract]

Scaffold-free and scaffold-assisted 3D culture enhances differentiation of bone marrow stromal cells.
Vidyasekar P, Shyamsunder P, Sahoo SK, Verma RS, In Vitro Cell Dev Biol Anim. 2015 Nov 5. [Abstract]

Scaffold-free, Human Mesenchymal Stem Cell-Based Tissue Engineered Blood Vessels.
Jung Y, Ji H, Chen Z, Fai Chan H, Atchison L, Klitzman B, Truskey G, Leong KW.
Sci Rep. 2015 Oct 12;5:15116. doi: 10.1038/srep15116. [Abstract] [Full Text]

Differentiation of transforming growth factor β1-induced mesenchymal stem cells into nucleus pulposus-like cells under simulated microgravity conditions.
Han C, Jiang C, Yu C, Shen H.Cell Mol Biol (Noisy-le-grand). 2015 May 16;61(2):50-5. [Abstract]

Increased proliferation and adhesion properties of human dental pulp stem cells in PLGA scaffolds via simulated microgravity. 
He L, Pan S, Li Y, Zhang W, Yi H, Song C, Niu Y. Int. Endod J. 2015 Feb 19. doi: 10:1111/iej.12441.  [Abstract]

The effects of spheroid formation of adipose-derived stem cells in a microgravity bioreactor on stemness properties and therapeutic potential.
Zhang S, Liu P, Chen L, Wang Y, Wang Z, Zhang B. Biomaterials. 2015 Feb;41:15-25. doi: 10.1016/j.biomaterials.2014.11.019. Epub 2014 Dec 1. [Abstract]

Low gravity rotational culture and the integration of immunomodulatory stem cells reduce human islet allo-reactivity. Qureshi KM, Lee J, Paget MB, Bailey CJ, Curnow SJ, Murray HE, Downing R. Clin. Transplant. 2015 Jan;29(1):90:8. doi: 10.1111/ctr.12488. Epub 2014 Dec 5. [Abstract] [Full Text pdf]
Spheriod cultures promote the stemness of corneal stromal cells.Li H1, Dai Y2, Shu J3, Yu R4, Guo Y2, Chen J5. Tissue Cell. 2014 Nov 7. pii: S0040-8166(14)00116-5. doi: 10.1016/j.tice.2014.10.008 [Epub ahead of print] [Abstract]
Non-genetic direct reprogramming and biomimetic platforms in a preliminary study for adipose-derived stem cells into corneal endothelia-like cells.Dai Y, Guo Y, Wang C, Liu Q, Yang Y, Li S, Guo X, Lian R, Yu R, Liu H, Chen J. PLoS One. 2014 Oct 15;9(10):e109856. doi:10.1371/journal.pone.0109856. [Abstract] [Full Text] [Full Text pdf]
Chondrogenic differentiation of human adipose derived stem cells using microcarrier and bioreactor combination technique.Kang H, Lu S, Peng J, Yang Q, Liu S, Zhang L, Huang J, Sui X, Zhao B, Wang A, Xu W, Guo Q, Song Q. Mol Med Rep. 2014 Oct 30. doi: 10.3892/mmr.2014.2820. [Abstract]
Effect of dynamic three-dimensional culture on osteogenic potential of human periodontal ligament-derived mesenchymal stem cells entrapped in alginate microbeads.Vecchiatini R, Penolazzi L, Lambertini E, Angelozzi M, Morganti C, Mazzitelli S, Trombelli L, Nastruzzi C, Piva R. J Periodontal Res. 2014 Sep 23. doi: 10.1111/jre.12225.  [Abstract]
The impact of simulated and real microgravity on bone cells and mesenchymal stem cells
Ulbrich C, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, Magnusson N, Infanger M, Grosse J, Eilles C, Sundaresan A, Grimm D. Biomed Res Int. 2014;2014:928507. doi: 10.1155/2014/928507.[Abstract] [Full Text] [Full Text pdf]
Tissue-Engineered Nerve Constructs Under a Microgravity System for Peripheral Nerve Regeneration.Luo H, Zhu B, Zhang Y, Jin Y. Tissue Eng Part A. 2014 Sep 16. (Epub ahead of print) [Abstract]
A novel perfused rotary bioreactor for cardiomyogenesis of embryonic stem cells.Teo A, Mantalaris A, Song K, Lim M Biotechnol Lett. 2014 May;36(5):947-60. doi:10.1007/s10529-014-1456-y. [Abstract]
Early exposure of murine embryonic stem cells to hematopoietic cytokines differentially directs definitive erythropoiesis and cardiomyogenesis in alginate hydrogel three-dimensional cultures. Fauzi I, Panoskaltsis N, Mantalaris A. Stem Cells Dev. 2014 Jun 13. (Epub ahead of print) [Abstract]
Rotary Suspension Culture Enhances Mesendoderm Differentiation of Embryonic Stem Cells Through Modulation of Wnt/β-catenin Pathway.Lei X, Deng Z, Zhang H, Zhao H, Zhou J, Liu S, Chen Q, Ning L, Cao Y, Wang X, Zhang X, Duan E. Stem Cell Rev. 2014 May 4. (Epub ahead of print) [Abstract]
Efficient large-scale generation of functional hepatocytes from mouse embryonic stem cells grown in a rotating bioreactor with exogenous growth factors and hormones. Zhang S, Zhang Y, Chen L, Liu T, Li Y, Wang Y, Geng Y.; Stem Cell Res Ther. 2013 Dec 2;4(6):145.[Abstract] [Full Text] [Full Text pdf]
Slow turning lateral vessel bioreactor improves embryoid body formation and cardiogenic differentiation of mouse embryonic stem cells. Rungarunlert S, Klincumhom N, Tharasanit T, Techakumphu M, Pirity MK, Dinnyes A.  Cell Reprogram. 2013 Oct;15(5):443-58. doi: 10.1089/cell.2012.0082.  [Abstract]
Nano-ceramic composite scaffolds for bioreactor-based bone engineering. Lv Q, Deng M, Ulery BD, Nair LS, Laurencin CT.Clin Orthop Relat Res. 2013 Aug;471(8):2422-33. doi: 10.1007/s11999-013-2859-0. [Abstract]
Characteristics of mesenchymal stem cells derived from Wharton's jelly of human umbilical cord and for fabrication of non-scaffold tissue-engineered cartilage. Liu S, Hou KD, Yuan M, Peng J, Zhang L, Sui X, Zhao B, Xu W, Wang A, Lu S, Guo Q.; J Biosci Bioeng. 2013 Jul 27. pii: S1389-1723(13)00263-6. doi: 10.1016/j.jbiosc.2013.07.001. [Abstract]
The effect of the microgravity rotating culture system on the chondrogenic differentiation of bone marrow mesenchymal stem cells. Wu X, Li SH, Lou LM, Chen ZR. Mol Biotechnol. 2013 Jun;54(2):331-6. doi: 10.1007/s12033-012-9568-x. [Abstract]
The simulated microgravity enhances multipotential differentiation capacity of bone marrow mesenchymal stem cells.
Wang N, Wang H, Chen J, Zhang X, Xie J, Li Z, Ma J, Wang W, Wang Z.; Cytotechnology. 2014 Jan;66(1):119-31. doi: 10.1007/s10616-013-9544-8. [Abstract]
Novel alginate three-dimensional static and rotating culture systems for effective ex vivo amplification of human cord blood hematopoietic stem cells and in vivo functional analysis of amplified cells in NOD/SCID mice. 
Yuan Y, Sin WY, Xue B, Ke Y, Tse KT, Chen Z, Xie Y, Xie Y. Transfusion. 2013 Feb 5. doi: 10.1111/trf.12103. [Abstract] 
Rotating microgravity-bioreactor cultivation enhances the hepatic differentiation of mouse embryonic stem cells on biodegradable polymer scaffolds.
Wang Y, Zhang Y, Zhang S, Peng G, Liu T, Li Y, Xiang D, Wassler MJ, Shelat HS, Geng Y. Tissue Eng Part A. 2012 Nov;18(21-22):2376-85. doi: 10.1089/ten.TEA.2012.0097. 2012 Sep 24. [Abstract] 
Engineered bone tissue associated with vascularization utilizing a rotating wall vessel bioreactor.
Nishi M, Matsumoto R, Dong J, Uemura T. J Biomed Mater Res A. 2012 Aug 3. doi: 10.1002/jbm.a.34340 [Abstract]
Differentiation of human mesenchymal stem cell spheroids under microgravity conditions
Cerwinka WH, Sharp SM, Boyan BD, Zhau HE, Chung LWK, Yates C,  Cell Regeneration 2012, 1:2  
[Abstract] [Full Text] [Full Text pdf]
The effect of Smads signal pathway on the osteogenesis of human periodontal ligament stem cells in simulated microgravity.
Li Y, Li S, Niu ZY, Bao B, Shi X.; Shanghai Kou Qiang Yi Xue. 2012 Jun;21(3):246-50.(Article in Chinese) [Abstract]
Beta-adrenoceptor pathway enhances mitochondrial function in human neural stem cells via rotary cell culture system.
Chiang MC, Lin H, Cheng YC, Yen CH, Huang RN, Lin KH. J Neurosci Methods. 2012 Jun 15;207(2):130-6.[Abstract]
Human elastic cartilage engineering from cartilage progenitor cells using rotating wall vessel bioreactor.
Takebe T, Kobayashi S, Kan H, Suzuki H, Yabuki Y, Mizuno M, Adegawa T, Yoshioka T, Tanaka J,Maegawa J, Taniguchi H. Transplant Proc. 2012 May;44(4):1158-61. [Abstract]
One-step articular cartilage repair: combination of in situ bone marrow stem cells with cell-free poly(L-lactic-co-glycolic acid) scaffold in a rabbit model.
Shi J, Zhang X, Zeng X, Zhu J, Pi Y, Zhou C, Ao Y. Orthopedics. 2012 May;35(5):e665-71. doi: 10.3928/01477447-20120426-20. [Abstract]
Properties of mechano-transduction via simulated microgravity and its effects on intracellular trafficking of VEGFR's.
Puca A, Russo G, Giordano A. Oncotarget. 2012 Apr; 3(4):426-34. [Abstract]
Freeze-dried human serum albumin improves the adherence and proliferation of mesenchymal stem cells on mineralized human bone allografts.
Weszl M, Skaliczki G, Cselenyák A, Kiss L, Major T, Schandl K, Bognár E, Stadler G, Peterbauer A, Csönge L. J Orthop Res. 2012 Mar;30(3):489-96. [Abstract]
Cementum protein 1 (CEMP1) induces differentiation by human periodontal ligament cells under three-dimensional culture conditions. 
Hoz L, Romo E, Zeichner-David M, Sanz M, Nuñez J, Gaitán L, Mercado G, Arzate H., Cell Biol Int.2012 Feb 1;36(2):129-36. [Abstract]
NASA-Approved Rotary Bioreactor Enhances Proliferation of Human Epidermal Stem Cells and Supports Formation of 3D Epidermis-Like Structure.
Lei XH, Ning LN, Cao YJ, Liu S, Zhang SB, Qiu ZF, Hu HM, Zhang HS, Liu S, Duan EK.PLoS One. 6(11):e26603; Nov 2011 [Abstract] [Full text] [Full text pdf]
Development of a novel three-dimensional, automatable and integrated bioprocess for the differentiation of embryonic stem cells into pulmonary alveolar cells in a rotating vessel bioreactor system. 
Ismail S, Samadikuchaksaraei A, Bishop A, Polak JM, Mantalaris A.Tissue Eng Part C Methods. 2012 Apr;18(4):263-72. doi: 10.1089/ten.TEC.2011.0299. [Abstract]
The simulated microgravity enhances the differentiation of mesenchymal stem cells into neurons.
Chen J, Liu R, Yang Y, Li J, Zhang X, Li J, Wang Z, Ma J. Neurosci Lett.;505(2):171-5. Nov 2011 [Abstract]
Simulated microgravity using a rotary cell culture system promotes chondrogenesis of human adipose-derived mesenchymal stem cells via the p38 MAPK pathway. 
Yu B, Yu D, Cao L, Zhao X, Long T, Liu G, Tang T, Zhu Z. Biochem Biophys Res Commun.;414(2):412-8 Oct 2011 [Abstract]
An epidermal stem cells niche microenvironment created by engineered human amniotic membrane.
Ji SZ, Xiao SC, Luo PF, Huang GF, Wang GY, Zhu SH, Wu MJ, Xia ZF Biomaterials.;32(31):7801-11, Nov 2011 [Abstract]
Enhanced cardiac differentiation of mouse embryonic stem cells by use of the slow-turning, lateral vessel (STLV) bioreactor.
Rungarunlert S, Klincumhom N, Bock I, Nemes C, Techakumphu M, Pirity MK, Dinnyes A. Biotechnol Lett. 2011 Aug;33(8):1565-73, 2011 [Abstract]
Reconstitution of hepatic tissue architectures from fetal liver cells obtained from a three-dimensional culture with a rotating wall vessel bioreactor.
Ishikawa M, Sekine K, Okamura A, Zheng YW, Ueno Y, Koike N, Tanaka J, Taniguchi H. J Biosci Bioeng. 111(6):711-8. June 2011 [Abstract]
Enhancement of matrix production and cell proliferation in human annulus cells under bioreactor culture.
Yang X, Wang D, Hao J, Gong M, Arlet V, Balian G, Shen FH, Li XJ. Tissue Eng Part A.; 17(11-12):1595-603, June 2011 [Abstract]
Computational modeling for the optimization of a cardiogenic 3D bioprocess of encapsulated embryonic stem cells.
Consolo F, Bariani C, Mantalaris A, Montevecchi F, Redaelli A, Morbiducci U. Biomech Model Mechanobiol., Apr 2011 [Abstract]
Chondrocytes and bone marrow-derived mesenchymal stem cells undergoing chondrogenesis in agarose hydrogels of solid and channelled architectures respond differentially to dynamic culture conditions.
Sheehy EJ, Buckley CT, Kelly DJ., J Tissue Eng Regen Med. 2011 Oct;5(9):747-58. doi: 10.1002/term.385. Epub Jan 2011 [Abstract]
Simultaneous expansion and harvest of hematopoietic stem cells and mesenchymal stem cells derived from umbilical cord blood.
Kedong S, Xiubo F, Tianqing L, Macedo HM, LiLi J, Meiyun F, Fangxin S, Xuehu M, Zhanfeng C 21(12):3183-93, 2010 [Abstract]
Unique differentiation profile of mouse embryonic stem cells in rotary and stirred tank bioreactors.
Fridley KM, Fernandez I, Li MT, Kettlewell RB, Roy K. Tissue Eng Part A; 16(11):3285-98, 2010 [Abstract]
Influence of acellular natural lung matrix on murine embryonic stem cell differentiation and tissue formation.
Cortiella J, Niles J, Cantu A, Brettler A, Pham A, Vargas G, Winston S, Wang J, Walls S, Nichols JE.Tissue Eng Part A. 16(8):2565-80, 2010 [Abstract]
NASA approved rotary bioreactor enhances proliferation and osteogenesis of human periodontal ligament stem cells.
Li S, Ma Z, Niu Z, Qian H, Xuan D, Hou R, Ni L.Stem Cells Dev. 18:1273-82, 2009 [Abstract]

The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering.
Hwang YS, Cho J, Tay F, Heng JY, Ho R, Kazarian SG, Williams DR, Boccaccini AR, Polak JM, Mantalaris A. Biomaterials 30: 499-507, 2008 [Abstract]
Reconstruction of Functional Cortical-Like Tissues from Neural Stem and Progenitor Cells.
Ma W, Tavakoli T, Chen S, Maric D, Liu JL, O'Shaughnessy TJ. Tissue Eng Part A 14: 1687-1697, 2008 [Abstract]
Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds and bioreactors.
August A, Marolt D, Freed LE, Vepari C, Meinel L, Farley M, Fajardo R, Patel M, Gray M, Kaplan DL, Vunjak-Novakovic G J R Soc Interface. 2008 Aug 6;5(25):929-39. doi: 10.1098/rsif.2007.1302 [Abstract[Full Text]
Improvement of culture conditions of human embryoid bodies using a controlled perfused and dialyzed bioreactor system. 
Come J, Nissan X, Aubry L, Tournois J, Girard M, Perrier AL, Peschanski M, Cailleret M. Tissue Eng Part C Methods 14: 289-298, 2008 [Abstract]
Engineering of Functional Cartilage Tissue Using Stem Cells from Synovial Lining: A Preliminary Study.
Pei M, He F, Kish VL, Vunjak-Novakovic G. Clin Orthop Relat Res 466: 1880-1889, 2008[Abstract] [Full Text] [Full Text pdf]
Integrated 3-Dimensional Expansion and Osteogenic Differentiation of Murine Embryonic Stem Cells.
Randle WL, Cha JM, Hwang YS, Chan KL, Kazarian SG, Polak JM, Mantalaris A.; Tissue Eng 13: 2957-2970, 2007 [Abstract]
Cell-cell and cell-extracellular matrix interactions regulate embryonic stem cell differentiation.
Chen SS, Fitzgerald W, Zimmerberg J, Kleinman HK, Margolis L.; Stem Cells 25: 553-561, 2007 [Abstract] [Full Text] [Full Text pdf]
Embryonic-like stem cells from umbilical cord blood and potential for neural modeling.
McGuckin C, Forraz N, Baradez MO, Basford C, Dickinson AM, Navran S, Hartgerink JD.; Acta Neurobiol 66: 321-329, 2006 [Abstract] [Full Text pdf]
Creation of engineered cardiac tissue in vitro from mouse embryonic stem cells.
Guo XM, Zhao YS, Chang HX, Wang CY, Ling-Ling E, Zhang XA, Duan CM, Dong LZ, Jiang H, Li J, Song Y, Yang XJ.; Circulation 113 :2229-2237, 2006. [Abstract] [Full Text] [Full Text pdf]
Bioreactor Expansion of Human Bone Marrow Mesenchymal Stem Cells.
Chen X, Xu H, Wan C, McCaigue M, Li G.;  Stem Cells 24: 2052-2059, 2006 [Abstract] [Full Text] [Full Text pdf]
Production of stem cells with embryonic characteristics from human umbilical cord blood.
McGuckin CP, Forraz N, Baradez MO, Navran S, Zhao J, Urban R, Tilton R, Denner L: Cell Prolif 38: 245-255, 2005. [Abstract]
Scalable production of embryoid bodies with the rotary cell culture system.
Wang XL, Wang CY, Yu XJ, Zhao YS, Li J, Duan CM, Guo XM:Sheng Li Xue Bao. 57:486-492, 2005.[Abstract in English] Article in Chinese
Modeled Microgravity Disrupts Collagen I/integrin Signaling During Osteoblastic Differentiation of Human Mesenchymal Stem Cells.
Meyers VE, Zayzafoon M, Gonda SR, Gathings WE, McDonald JM: J Cell Biochem. 93: 697-707, 2004. [Abstract]
Complex Extracellular Matrices Promote Tissue-specific Stem Cell Differentiation.
Philp D, Chen SS, Fitzgerald W, Orenstein J, Margolis L, Kleinman HK: Stem Cells 23: 288-296, 2005.[Abstract] [Full Text] [Full Text pdf]
Bioreactor Cultivation Enhances NTEB Formation and Differentiation of NTES Cells into Cardiomyocytes.Lu S, Liu S, He W, Duan C, Li Y, Liu Z, Hao T, Wang Y, Li D, Wang C, Gao S: Cloning Stem Cells 10:363-370, 2008 [Abstract]
Neural Stem Cell Differentiation in a Cell-collagen-bioreactor Culture System.
Lin HJ, O’Shaughnessy TJ, Kelly J, Ma W: Dev Brain Res. 153: 163-173, 2004 [Abstract]
Bioreactor Cultivation Enhances the Efficiency of Human Embryoid Body (hEB) Formation and Differentiation.
Gerecht-Nir S, Cohen S, Itskovitz-Eldor J: Biotechnology and Bioengineering : 86: 493-502, 2004. [Abstract]
 Modeled Microgravity Inhibits Osteogenic Differentiation of Human Mesenchymal Stem Cells and Increases Adipogenesis. Zayzafoon M, Gathings WE, McDonald JM; Endocrinology: 145 2421-2432, 2004. [Abstract] [Full Text] [Full Text pdf]
Rhythmicity of Engraftment and Altered Cell Cycle Kinetics of Cytokine-Cultured Murine Marrow in Simulated Microgravity Compared With Static Cultures.
Colvin GA, Lambert JF, Carlson JE, McAuliffe CI, Abedi M, Quesenberry PJ: In Vitro Cell Dev Bio Anim 38: 343-351, 2002. [Abstract]
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