Synthecon: 3D Culture Systems for 3D World!

Research Publications / Viral

U94 of human herpesvirus 6 down-modulates Src, promotes a partial mesenchymal-to-epithelial transition and inhibits tumor cell growth, invasion and metastasis.
Caccuri F, Ronca R, Laimbacher AS, Berenzi A, Steimberg N, Campilongo F, Mazzuca P, Giacomini A, Mazzoleni G, Benetti A, Caselli E, Presta M, Di Luca D, Fraefel C, Caruso A.
Oncotarget. 2017 May 11. doi: 10.18632/oncotarget.17817. [Abstract]

Three-Dimensional Rotating Wall Vessel-Derived Cell Culture Models for Studying Virus-Host Interactions.
Gardner JK, Herbst-Kralovetz MM.Viruses. 2016 Nov 9;8(11). pii: E304. [Abstract] [FullText]

A Study of Alterations in DNA Epigenetic Modifications (5mC and 5hmC) and Gene Expression Influenced by Simulated Microgravity in Human Lymphoblastoid Cells.
Chowdhury B, Seetharam A, Wang Z, Liu Y, Lossie AC, Thimmapuram J, Irudayaraj J. PLoS One. 2016 Jan 28;11(1):e0147514. doi: 10.1371/journal.pone.0147514. eCollection 2016. [Abstract] [Full Text]

3D rotating wall vessel and 2D cell culture of four veterinary virus pathogens: A comparison of virus yields, portions of infectious particles and virus growth curves.
Malenovská H. J Virol Methods. 2015 Nov 9. pii: S0166-0934(15)00356-0. doi: 10.1016/j.jviromet.2015.11.002. [Abstract] 

3D tissue-like assemblies: A novel approach to investigate virus-cell interactions.
Goodwin TJ, McCarthy M, Cohrs RJ, Kaufer BB. Methods. 2015 May 15. pii: S1046-2023(15)00203-0. doi: 10.1016/j.ymeth.2015.05.010. [Abstract]
In vitro model of placental trophoblast differentiation and cytomegalovirus infection.
Swan KF, Ferris M, Pridjian G, Morris CA, Sullivan DE. Pregnancy Hypertens. 2015 Jan;5 (1): 155-6. doi: 10.1016/j.preghy.2014.10.323.[Abstract] [Full Text pdf]
Lack of norovirus replication and histo-blood group antigen expression in 3-dimensional intestinal epithelial cells.
Herbst-Kralovetz MM1, Radtke AL, Lay MK, Hjelm BE, Bolick AN, Sarker SS, Atmar RL, Kingsley DH, Arntzen CJ, Estes MK, Nickerson CA. Emerg Infect Dis. 2013 Mar;19(3):431-8. doi: 10.3201/eid1903.121029
[Abstract] [Full Text] [Full Text pdf]
Characterization of Epstein-Barr virus reactivation in a modeled spaceflight system.
Brinley AA, Theriot CA, Nelman-Gonzalez M, Crucian B, Stowe RP, Barrett AD, Pierson DL. J Cell Biochem. 2013 Mar;114(3):616-24. doi: 10.1002/jcb.24403. [Abstract]
Replication of hepatitis E virus in three-dimensional cell culture.
Berto A, Van der Poel WH, Hakze-van der Honing R, Martelli F, La Rogione RM, Inglese N, Collins J, Grierson S, Johne R, Reetz J, Dastjerdi A, Banks M. J Virol Methods. 2013 Feb;187(2):327-32. doi: 10.1016/j.jviromet2012.10.017.Epub 2012 Nov 14 [Abstract] [Full Text]
Human norovirus infection of caco-2 cells grown as a three-dimensional tissue structure.
Straub TM, Bartholomew RA, Valdez CO, Valentine NB, Dohnalkova A, Ozanich RM, Bruckner-Lea CJ, Call DR. J Water Health. 2011 Jun;9(2):225-40. [Abstract] [Full Text] [Full Text pdf]
In vitro Cell Culture Infectivity Assay for Human Noroviruses.
Straub TM, Honer zu Bentrup K, Orosz-Coghlan, P, Dohnalkova A, Mayer BK, Bartholomew RA, Valdez CO, Bruckner-Lea C, Gerba CP, Abbaszadegan M, Nickerson CA, Emerging Infectious Diseases 13: 396-403, 2007 [Abstract] [Full Text] [Full Text pdf]
Virus Latently Infected Cells are Selectively Deleted in Simulated Microgravity Cultures.
Hughes JH and Long JP: Epstein-Barr; In Vitro Cell Dev Biol Anim 37: 223-230, 2001. [Abstract]
Suppression of Epstein-Barr Virus Reactivation in Lymphoblastoid Cells Cultured in Simulated Microgravity.
Long JP, Pierson S, and Hughes JH:  In Vitro Cell Dev Biol Anim 35: 49-54, 1999. [Abstract]
Rhinovirus Replication in HeLa Cells Cultured Under Conditions of Simulated Microgravity.
Long JP, Pierson S, Hughes JH:  Aviat Space Environ Med 69: 851-856, 1998. [Abstract]
Lymphocyte Trafficking and HIV Infection of Human Lymphoid Tissue in a Rotating Wall Vessel Bioreactor.
Margolis L, Fitzgerald W, Glushakova S, Hatfill S, Amichay N, Baibakov B and Zimmerberg J: AIDS Res Hum Retroviruses 13: 1411-1420, 1997. [Abstract]
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